Random Lasing for Bimodal Imaging and Detection of Tumor
The interaction of light with biological tissues is an intriguing area of research that has led to the development of numerous techniques and technologies. The randomness inherent in biological tissues can trap light through multiple scattering events and provide optical feedback to generate random...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
|
| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/13/12/1003 |
| _version_ | 1797381804550782976 |
|---|---|
| author | R. Gayathri C. S. Suchand Sandeep C. Vijayan V. M. Murukeshan |
| author_facet | R. Gayathri C. S. Suchand Sandeep C. Vijayan V. M. Murukeshan |
| author_sort | R. Gayathri |
| collection | DOAJ |
| description | The interaction of light with biological tissues is an intriguing area of research that has led to the development of numerous techniques and technologies. The randomness inherent in biological tissues can trap light through multiple scattering events and provide optical feedback to generate random lasing emission. The emerging random lasing signals carry sensitive information about the scattering dynamics of the medium, which can help in identifying abnormalities in tissues, while simultaneously functioning as an illumination source for imaging. The early detection and imaging of tumor regions are crucial for the successful treatment of cancer, which is one of the major causes of mortality worldwide. In this paper, a bimodal spectroscopic and imaging system, capable of identifying and imaging tumor polyps as small as 1 mm<sup>2</sup>, is proposed and illustrated using a phantom sample for the early diagnosis of tumor growth. The far-field imaging capabilities of the developed system can enable non-contact in vivo inspections. The integration of random lasing principles with sensing and imaging modalities has the potential to provide an efficient, minimally invasive, and cost-effective means of early detection and treatment of various diseases, including cancer. |
| first_indexed | 2024-03-08T20:57:40Z |
| format | Article |
| id | doaj.art-60db9840fb8643bfb6640d5c14f37e2c |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-08T20:57:40Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-60db9840fb8643bfb6640d5c14f37e2c2023-12-22T13:56:18ZengMDPI AGBiosensors2079-63742023-11-011312100310.3390/bios13121003Random Lasing for Bimodal Imaging and Detection of TumorR. Gayathri0C. S. Suchand Sandeep1C. Vijayan2V. M. Murukeshan3Centre for Optical and Laser Engineering (COLE), School of Mechanical and Aerospace Engineering, Nanyang Technological University (NTU), Singapore 639798, SingaporeCentre for Optical and Laser Engineering (COLE), School of Mechanical and Aerospace Engineering, Nanyang Technological University (NTU), Singapore 639798, SingaporeDepartment of Physics, Indian Institute of Technology Madras (IITM), Chennai 600036, IndiaCentre for Optical and Laser Engineering (COLE), School of Mechanical and Aerospace Engineering, Nanyang Technological University (NTU), Singapore 639798, SingaporeThe interaction of light with biological tissues is an intriguing area of research that has led to the development of numerous techniques and technologies. The randomness inherent in biological tissues can trap light through multiple scattering events and provide optical feedback to generate random lasing emission. The emerging random lasing signals carry sensitive information about the scattering dynamics of the medium, which can help in identifying abnormalities in tissues, while simultaneously functioning as an illumination source for imaging. The early detection and imaging of tumor regions are crucial for the successful treatment of cancer, which is one of the major causes of mortality worldwide. In this paper, a bimodal spectroscopic and imaging system, capable of identifying and imaging tumor polyps as small as 1 mm<sup>2</sup>, is proposed and illustrated using a phantom sample for the early diagnosis of tumor growth. The far-field imaging capabilities of the developed system can enable non-contact in vivo inspections. The integration of random lasing principles with sensing and imaging modalities has the potential to provide an efficient, minimally invasive, and cost-effective means of early detection and treatment of various diseases, including cancer.https://www.mdpi.com/2079-6374/13/12/1003random lasingtumorearly detectionimagingspectroscopycancer |
| spellingShingle | R. Gayathri C. S. Suchand Sandeep C. Vijayan V. M. Murukeshan Random Lasing for Bimodal Imaging and Detection of Tumor Biosensors random lasing tumor early detection imaging spectroscopy cancer |
| title | Random Lasing for Bimodal Imaging and Detection of Tumor |
| title_full | Random Lasing for Bimodal Imaging and Detection of Tumor |
| title_fullStr | Random Lasing for Bimodal Imaging and Detection of Tumor |
| title_full_unstemmed | Random Lasing for Bimodal Imaging and Detection of Tumor |
| title_short | Random Lasing for Bimodal Imaging and Detection of Tumor |
| title_sort | random lasing for bimodal imaging and detection of tumor |
| topic | random lasing tumor early detection imaging spectroscopy cancer |
| url | https://www.mdpi.com/2079-6374/13/12/1003 |
| work_keys_str_mv | AT rgayathri randomlasingforbimodalimaginganddetectionoftumor AT cssuchandsandeep randomlasingforbimodalimaginganddetectionoftumor AT cvijayan randomlasingforbimodalimaginganddetectionoftumor AT vmmurukeshan randomlasingforbimodalimaginganddetectionoftumor |