Copper deficiency, a new triad: anemia, leucopenia, and myeloneuropathy
Clinical copper deficiency is now more frequently recognized. Hematologically, it can present as anemia (microcytic, normocytic, or macrocytic) and neutropenia. Thrombocytopenia is relatively rare. Neurologically, it can manifest as myelopathy and peripheral neuropathy simulating subacute combined d...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Greater Baltimore Medical Center
2017-10-01
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| Series: | Journal of Community Hospital Internal Medicine Perspectives |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/20009666.2017.1351289 |
| _version_ | 1797972995906469888 |
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| author | Shoaib M. Wazir Ibrahim Ghobrial |
| author_facet | Shoaib M. Wazir Ibrahim Ghobrial |
| author_sort | Shoaib M. Wazir |
| collection | DOAJ |
| description | Clinical copper deficiency is now more frequently recognized. Hematologically, it can present as anemia (microcytic, normocytic, or macrocytic) and neutropenia. Thrombocytopenia is relatively rare. Neurologically, it can manifest as myelopathy and peripheral neuropathy simulating subacute combined degeneration. Bone marrow findings can mimic myelodysplasia resulting in occasional inappropriate referral for bone marrow transplantation. Other conditions with similar presentations include infections, drug toxicity, autoimmunity, B12 deficiency, folate deficiency, myelodysplastic syndrome, aplastic anemia, and lymphoma with bone marrow involvement. Hematological, but not neurological, manifestations respond promptly to copper replacement, making early diagnosis essential for good outcome. Common risk factors for copper deficiency are foregut surgery, dietary deficiency, enteropathies with malabsorption, and prolonged intravenous nutrition (total parenteral nutrition). We present a unique case of copper deficiency, with no apparent known risk factors. |
| first_indexed | 2024-04-11T03:57:21Z |
| format | Article |
| id | doaj.art-60de0a11738f41ca908b497c8d8f6e70 |
| institution | Directory Open Access Journal |
| issn | 2000-9666 |
| language | English |
| last_indexed | 2024-04-11T03:57:21Z |
| publishDate | 2017-10-01 |
| publisher | Greater Baltimore Medical Center |
| record_format | Article |
| series | Journal of Community Hospital Internal Medicine Perspectives |
| spelling | doaj.art-60de0a11738f41ca908b497c8d8f6e702023-01-02T00:18:44ZengGreater Baltimore Medical CenterJournal of Community Hospital Internal Medicine Perspectives2000-96662017-10-017426526810.1080/20009666.2017.13512891351289Copper deficiency, a new triad: anemia, leucopenia, and myeloneuropathyShoaib M. Wazir0Ibrahim Ghobrial1UPMC Mercy HospitalUPMC McKeesport HospitalClinical copper deficiency is now more frequently recognized. Hematologically, it can present as anemia (microcytic, normocytic, or macrocytic) and neutropenia. Thrombocytopenia is relatively rare. Neurologically, it can manifest as myelopathy and peripheral neuropathy simulating subacute combined degeneration. Bone marrow findings can mimic myelodysplasia resulting in occasional inappropriate referral for bone marrow transplantation. Other conditions with similar presentations include infections, drug toxicity, autoimmunity, B12 deficiency, folate deficiency, myelodysplastic syndrome, aplastic anemia, and lymphoma with bone marrow involvement. Hematological, but not neurological, manifestations respond promptly to copper replacement, making early diagnosis essential for good outcome. Common risk factors for copper deficiency are foregut surgery, dietary deficiency, enteropathies with malabsorption, and prolonged intravenous nutrition (total parenteral nutrition). We present a unique case of copper deficiency, with no apparent known risk factors.http://dx.doi.org/10.1080/20009666.2017.1351289Copperanemialeukopeniamyelopathy |
| spellingShingle | Shoaib M. Wazir Ibrahim Ghobrial Copper deficiency, a new triad: anemia, leucopenia, and myeloneuropathy Journal of Community Hospital Internal Medicine Perspectives Copper anemia leukopenia myelopathy |
| title | Copper deficiency, a new triad: anemia, leucopenia, and myeloneuropathy |
| title_full | Copper deficiency, a new triad: anemia, leucopenia, and myeloneuropathy |
| title_fullStr | Copper deficiency, a new triad: anemia, leucopenia, and myeloneuropathy |
| title_full_unstemmed | Copper deficiency, a new triad: anemia, leucopenia, and myeloneuropathy |
| title_short | Copper deficiency, a new triad: anemia, leucopenia, and myeloneuropathy |
| title_sort | copper deficiency a new triad anemia leucopenia and myeloneuropathy |
| topic | Copper anemia leukopenia myelopathy |
| url | http://dx.doi.org/10.1080/20009666.2017.1351289 |
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