Thyrotrophin receptor antibody is not associated with thyroid cancer in patients with toxic nodular and multinodular goiter
INTRODUCTION: Increased thyrotrophin receptor antibody (TRAb) was associated with thyroid cancer risk and aggressivity in patients with Graves disease. This relation was not investigated in patients with toxic nodular goiter (TNG) and toxic multinodular goiter (TMNG). We aimed to evaluate associatio...
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| Format: | Article |
| Language: | English |
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Ankara Yildirim Beyazit University
2020-03-01
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| Series: | Ankara Medical Journal |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=amj&un=AMJ-79553 |
| _version_ | 1828030420120240128 |
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| author | Cevdet Aydın Husniye Baser Neslihan Cuhaci Didem Ozdemir Abdussamed Yalcin Elif Ozdemir Reyhan Ersoy Bekir Cakir |
| author_facet | Cevdet Aydın Husniye Baser Neslihan Cuhaci Didem Ozdemir Abdussamed Yalcin Elif Ozdemir Reyhan Ersoy Bekir Cakir |
| author_sort | Cevdet Aydın |
| collection | DOAJ |
| description | INTRODUCTION: Increased thyrotrophin receptor antibody (TRAb) was associated with thyroid cancer risk and aggressivity in patients with Graves disease. This relation was not investigated in patients with toxic nodular goiter (TNG) and toxic multinodular goiter (TMNG). We aimed to evaluate association between TRAb and thyroid cancer in patients with TNG and TMNG. METHODS: Patients who underwent thyroidectomy with a preoperative diagnosis of TNG and TMNG were reviewed retrospectively. Among 370 patients, TRAb was available in 191 TMNG and 30 TNG patients. RESULTS: TRAb was positive in 24 (10.86%) of 221 patients with TNG/TMNG. Histopathological result was malignant in 71 (32.13%) and benign in 150 (67.87%) patients. TRAb was positive in 7 (9.86%) of 71 malignant and 17 (11.33%) of 150 benign patients (p=0.742). Age, sex, serum thyrotrophin, free triiodothyronine, free thyroxine, anti-thyroid peroxidase and anti-thyroglobulin positivity, and histological tumor type did not differ between patients with positive and negative TRAb (p=0.393, p=0.401, p=0.403, p=0.903, p=0.877, p=0.788, p=0.540, and p=0.357, respectively). There was papillary thyroid cancer (PTC) in 7 (29.17%) patients with positive TRAb and 57 (28.93%) patients with negative TRAb (p=0.357). The variant of PTC was classical in 5 (71.43%) patients with positive and 50 (87.72%) patients with negative TRAb (p=0.242). DISCUSSION AND CONCLUSION: In this study, we showed that TRAb positivity did not increase the risk of malignancy in patients with TNG/TMNG. |
| first_indexed | 2024-04-10T14:28:29Z |
| format | Article |
| id | doaj.art-60df114378b240db9a30507bb6ba85b5 |
| institution | Directory Open Access Journal |
| issn | 2148-4570 |
| language | English |
| last_indexed | 2024-04-10T14:28:29Z |
| publishDate | 2020-03-01 |
| publisher | Ankara Yildirim Beyazit University |
| record_format | Article |
| series | Ankara Medical Journal |
| spelling | doaj.art-60df114378b240db9a30507bb6ba85b52023-02-15T16:08:57ZengAnkara Yildirim Beyazit UniversityAnkara Medical Journal2148-45702020-03-0120123424110.5505/amj.2020.79553AMJ-79553Thyrotrophin receptor antibody is not associated with thyroid cancer in patients with toxic nodular and multinodular goiterCevdet Aydın0Husniye Baser1Neslihan Cuhaci2Didem Ozdemir3Abdussamed Yalcin4Elif Ozdemir5Reyhan Ersoy6Bekir Cakir7Ankara Yildirim Beyazit University Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, TurkeyAnkara Yildirim Beyazit University Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, TurkeyAnkara Yildirim Beyazit University Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, TurkeyAnkara Yildirim Beyazit University Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, TurkeyAnkara Yildirim Beyazit University Faculty of Medicine, Department of General Surgery, Ankara, TurkeyAnkara Yildirim Beyazit University Faculty of Medicine, Department of Nuclear Medicine, Ankara, TurkeyAnkara Yildirim Beyazit University Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, TurkeyAnkara Yildirim Beyazit University Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, TurkeyINTRODUCTION: Increased thyrotrophin receptor antibody (TRAb) was associated with thyroid cancer risk and aggressivity in patients with Graves disease. This relation was not investigated in patients with toxic nodular goiter (TNG) and toxic multinodular goiter (TMNG). We aimed to evaluate association between TRAb and thyroid cancer in patients with TNG and TMNG. METHODS: Patients who underwent thyroidectomy with a preoperative diagnosis of TNG and TMNG were reviewed retrospectively. Among 370 patients, TRAb was available in 191 TMNG and 30 TNG patients. RESULTS: TRAb was positive in 24 (10.86%) of 221 patients with TNG/TMNG. Histopathological result was malignant in 71 (32.13%) and benign in 150 (67.87%) patients. TRAb was positive in 7 (9.86%) of 71 malignant and 17 (11.33%) of 150 benign patients (p=0.742). Age, sex, serum thyrotrophin, free triiodothyronine, free thyroxine, anti-thyroid peroxidase and anti-thyroglobulin positivity, and histological tumor type did not differ between patients with positive and negative TRAb (p=0.393, p=0.401, p=0.403, p=0.903, p=0.877, p=0.788, p=0.540, and p=0.357, respectively). There was papillary thyroid cancer (PTC) in 7 (29.17%) patients with positive TRAb and 57 (28.93%) patients with negative TRAb (p=0.357). The variant of PTC was classical in 5 (71.43%) patients with positive and 50 (87.72%) patients with negative TRAb (p=0.242). DISCUSSION AND CONCLUSION: In this study, we showed that TRAb positivity did not increase the risk of malignancy in patients with TNG/TMNG.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=amj&un=AMJ-79553thyrotrophin receptor antibodytoxic nodular goitertoxic multinodular goiterthyroid cancer |
| spellingShingle | Cevdet Aydın Husniye Baser Neslihan Cuhaci Didem Ozdemir Abdussamed Yalcin Elif Ozdemir Reyhan Ersoy Bekir Cakir Thyrotrophin receptor antibody is not associated with thyroid cancer in patients with toxic nodular and multinodular goiter Ankara Medical Journal thyrotrophin receptor antibody toxic nodular goiter toxic multinodular goiter thyroid cancer |
| title | Thyrotrophin receptor antibody is not associated with thyroid cancer in patients with toxic nodular and multinodular goiter |
| title_full | Thyrotrophin receptor antibody is not associated with thyroid cancer in patients with toxic nodular and multinodular goiter |
| title_fullStr | Thyrotrophin receptor antibody is not associated with thyroid cancer in patients with toxic nodular and multinodular goiter |
| title_full_unstemmed | Thyrotrophin receptor antibody is not associated with thyroid cancer in patients with toxic nodular and multinodular goiter |
| title_short | Thyrotrophin receptor antibody is not associated with thyroid cancer in patients with toxic nodular and multinodular goiter |
| title_sort | thyrotrophin receptor antibody is not associated with thyroid cancer in patients with toxic nodular and multinodular goiter |
| topic | thyrotrophin receptor antibody toxic nodular goiter toxic multinodular goiter thyroid cancer |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=amj&un=AMJ-79553 |
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