Role of VEGF-VEGFR2 signaling pathway in psoriasis
VEGF-VEGFR2 signaling pathway plays an important role in the course of psoriasis. Binding of VEGF to VEGFR2 induces receptor dimerization and autophosphorylation at multiple tyrosine sites, promoting the activation of the downstream ERK1/2 signaling pathway. Phosphorylated ERK1/2 is highly expressed...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
2022-10-01
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| Series: | Pifu-xingbing zhenliaoxue zazhi |
| Subjects: | |
| Online Access: | http://pfxbzlx.gdvdc.com/CN/10.3969/j.issn.1674-8468.2022.05.018 |
| _version_ | 1797732648173436928 |
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| author | Xiaomei LUO Zhiyong CHENG Xiaoqun HAN Yong WANG |
| author_facet | Xiaomei LUO Zhiyong CHENG Xiaoqun HAN Yong WANG |
| author_sort | Xiaomei LUO |
| collection | DOAJ |
| description | VEGF-VEGFR2 signaling pathway plays an important role in the course of psoriasis. Binding of VEGF to VEGFR2 induces receptor dimerization and autophosphorylation at multiple tyrosine sites, promoting the activation of the downstream ERK1/2 signaling pathway. Phosphorylated ERK1/2 is highly expressed in keratinocytes in psoriatic lesions, while VEGFR2 activation induces ERK1/2 phosphorylation and upregulates the expression of keratin K6, K16, and K17. At the same time, the activation of ERK1/2 can enhance inflammatory response and vascular proliferation. Therefore, blockade of VEGF-mediated vegF-VEGFR2 signaling pathway can regulate the expression of downstream genes in VEGF-VEGFR2 signaling pathway. VEGF and VEGFR2, the key molecules in VEGF-VEGFR2 signaling pathway, may serve as potential therapeutic targets for psoriasis. VEGF inhibitors can block vegF-VEGFR2 signaling pathway by inhibiting VEGF or VEGFR2, playing a therapeutic role in psoriasis. In this review, we review the recent advances in the involvement of VEGF-VEGFR2 pathway in psoriasis. |
| first_indexed | 2024-03-12T12:16:38Z |
| format | Article |
| id | doaj.art-60dfb3fd1210489c8bea7f8777750ce5 |
| institution | Directory Open Access Journal |
| issn | 1674-8468 |
| language | zho |
| last_indexed | 2024-03-12T12:16:38Z |
| publishDate | 2022-10-01 |
| publisher | editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology |
| record_format | Article |
| series | Pifu-xingbing zhenliaoxue zazhi |
| spelling | doaj.art-60dfb3fd1210489c8bea7f8777750ce52023-08-30T11:38:45Zzhoeditoiral office of Journal of Diagnosis and Therapy on Dermato-venereologyPifu-xingbing zhenliaoxue zazhi1674-84682022-10-0129548248610.3969/j.issn.1674-8468.2022.05.018Role of VEGF-VEGFR2 signaling pathway in psoriasisXiaomei LUOZhiyong CHENGXiaoqun HANYong WANGVEGF-VEGFR2 signaling pathway plays an important role in the course of psoriasis. Binding of VEGF to VEGFR2 induces receptor dimerization and autophosphorylation at multiple tyrosine sites, promoting the activation of the downstream ERK1/2 signaling pathway. Phosphorylated ERK1/2 is highly expressed in keratinocytes in psoriatic lesions, while VEGFR2 activation induces ERK1/2 phosphorylation and upregulates the expression of keratin K6, K16, and K17. At the same time, the activation of ERK1/2 can enhance inflammatory response and vascular proliferation. Therefore, blockade of VEGF-mediated vegF-VEGFR2 signaling pathway can regulate the expression of downstream genes in VEGF-VEGFR2 signaling pathway. VEGF and VEGFR2, the key molecules in VEGF-VEGFR2 signaling pathway, may serve as potential therapeutic targets for psoriasis. VEGF inhibitors can block vegF-VEGFR2 signaling pathway by inhibiting VEGF or VEGFR2, playing a therapeutic role in psoriasis. In this review, we review the recent advances in the involvement of VEGF-VEGFR2 pathway in psoriasis.http://pfxbzlx.gdvdc.com/CN/10.3969/j.issn.1674-8468.2022.05.018psoriasisvegf-vegfr2 signaling pathway |
| spellingShingle | Xiaomei LUO Zhiyong CHENG Xiaoqun HAN Yong WANG Role of VEGF-VEGFR2 signaling pathway in psoriasis Pifu-xingbing zhenliaoxue zazhi psoriasis vegf-vegfr2 signaling pathway |
| title | Role of VEGF-VEGFR2 signaling pathway in psoriasis |
| title_full | Role of VEGF-VEGFR2 signaling pathway in psoriasis |
| title_fullStr | Role of VEGF-VEGFR2 signaling pathway in psoriasis |
| title_full_unstemmed | Role of VEGF-VEGFR2 signaling pathway in psoriasis |
| title_short | Role of VEGF-VEGFR2 signaling pathway in psoriasis |
| title_sort | role of vegf vegfr2 signaling pathway in psoriasis |
| topic | psoriasis vegf-vegfr2 signaling pathway |
| url | http://pfxbzlx.gdvdc.com/CN/10.3969/j.issn.1674-8468.2022.05.018 |
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