Peripheral Blood-Based Biomarkers for Immune Checkpoint Inhibitors
As cancer immunotherapy using immune checkpoint inhibitors (ICIs) is rapidly evolving in clinical practice, it is necessary to identify biomarkers that will allow the selection of cancer patients who will benefit most or least from ICIs and to longitudinally monitor patients’ immune responses during...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/17/9414 |
| _version_ | 1797521307212972032 |
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| author | Ho Jung An Hong Jae Chon Chan Kim |
| author_facet | Ho Jung An Hong Jae Chon Chan Kim |
| author_sort | Ho Jung An |
| collection | DOAJ |
| description | As cancer immunotherapy using immune checkpoint inhibitors (ICIs) is rapidly evolving in clinical practice, it is necessary to identify biomarkers that will allow the selection of cancer patients who will benefit most or least from ICIs and to longitudinally monitor patients’ immune responses during treatment. Various peripheral blood-based immune biomarkers are being identified with recent advances in high-throughput multiplexed analytical technologies. The identification of these biomarkers, which can be easily detected in blood samples using non-invasive and repeatable methods, will contribute to overcoming the limitations of previously used tissue-based biomarkers. Here, we discuss the potential of circulating immune cells, soluble immune and inflammatory molecules, circulating tumor cells and DNA, exosomes, and the blood-based tumor mutational burden, as biomarkers for the prediction of immune responses and clinical benefit from ICI treatment in patients with advanced cancer. |
| first_indexed | 2024-03-10T08:10:45Z |
| format | Article |
| id | doaj.art-60e13b2955a74ea0bbc7f59bbf9fd6ff |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T08:10:45Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-60e13b2955a74ea0bbc7f59bbf9fd6ff2023-11-22T10:43:06ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012217941410.3390/ijms22179414Peripheral Blood-Based Biomarkers for Immune Checkpoint InhibitorsHo Jung An0Hong Jae Chon1Chan Kim2Department of Medical Oncology, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaMedical Oncology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam 13496, KoreaMedical Oncology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam 13496, KoreaAs cancer immunotherapy using immune checkpoint inhibitors (ICIs) is rapidly evolving in clinical practice, it is necessary to identify biomarkers that will allow the selection of cancer patients who will benefit most or least from ICIs and to longitudinally monitor patients’ immune responses during treatment. Various peripheral blood-based immune biomarkers are being identified with recent advances in high-throughput multiplexed analytical technologies. The identification of these biomarkers, which can be easily detected in blood samples using non-invasive and repeatable methods, will contribute to overcoming the limitations of previously used tissue-based biomarkers. Here, we discuss the potential of circulating immune cells, soluble immune and inflammatory molecules, circulating tumor cells and DNA, exosomes, and the blood-based tumor mutational burden, as biomarkers for the prediction of immune responses and clinical benefit from ICI treatment in patients with advanced cancer.https://www.mdpi.com/1422-0067/22/17/9414peripheral bloodbiomarkercancer immunotherapyimmune checkpoint inhibitor |
| spellingShingle | Ho Jung An Hong Jae Chon Chan Kim Peripheral Blood-Based Biomarkers for Immune Checkpoint Inhibitors International Journal of Molecular Sciences peripheral blood biomarker cancer immunotherapy immune checkpoint inhibitor |
| title | Peripheral Blood-Based Biomarkers for Immune Checkpoint Inhibitors |
| title_full | Peripheral Blood-Based Biomarkers for Immune Checkpoint Inhibitors |
| title_fullStr | Peripheral Blood-Based Biomarkers for Immune Checkpoint Inhibitors |
| title_full_unstemmed | Peripheral Blood-Based Biomarkers for Immune Checkpoint Inhibitors |
| title_short | Peripheral Blood-Based Biomarkers for Immune Checkpoint Inhibitors |
| title_sort | peripheral blood based biomarkers for immune checkpoint inhibitors |
| topic | peripheral blood biomarker cancer immunotherapy immune checkpoint inhibitor |
| url | https://www.mdpi.com/1422-0067/22/17/9414 |
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