Bioactive compounds from dietary whole grape seed meal improved colonic inflammation via inhibition of MAPKs and NF-kB signaling in pigs with DSS induced colitis
The management of Inflammatory Bowel Diseases symptoms is focused to find new alternative strategies which could have beneficial effects on intestinal inflammation including the nutritional interventions. Using an in vivo approach together with gene and protein analysis, we investigated the effect o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-03-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619306322 |
| _version_ | 1819320514387116032 |
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| author | Gina Cecilia Pistol Daniela Eliza Marin Mircea Catalin Rotar Mariana Ropota Ionelia Taranu |
| author_facet | Gina Cecilia Pistol Daniela Eliza Marin Mircea Catalin Rotar Mariana Ropota Ionelia Taranu |
| author_sort | Gina Cecilia Pistol |
| collection | DOAJ |
| description | The management of Inflammatory Bowel Diseases symptoms is focused to find new alternative strategies which could have beneficial effects on intestinal inflammation including the nutritional interventions. Using an in vivo approach together with gene and protein analysis, we investigated the effect of a diet with 8% grape seed meal on inflammatory markers and signaling pathway molecules. DSS-challenged pigs were used as IBD animal model. Our results showed that the DSS treatment induced a widespread inflammation at colon level by increasing a wide range of pro-inflammatory molecules via activation of pro-inflammatory p38/ERK/JNK MAPK signaling cascades followed by activation of NF-kB and other nuclear receptors. Diet with grape seed meal was efficient in counteracting inflammatory disorders by inhibiting MAPKs, attenuating NF-kB gene and protein expression and diminishing pro-inflammatory cytokines and chemokines production toward the control level. Grape seed meal could be used as alternative food supplements to reduce inflammation at intestinal level. |
| first_indexed | 2024-12-24T11:20:47Z |
| format | Article |
| id | doaj.art-60e1cf344ddd443383d130bddd527474 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-24T11:20:47Z |
| publishDate | 2020-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-60e1cf344ddd443383d130bddd5274742022-12-21T16:58:15ZengElsevierJournal of Functional Foods1756-46462020-03-0166103708Bioactive compounds from dietary whole grape seed meal improved colonic inflammation via inhibition of MAPKs and NF-kB signaling in pigs with DSS induced colitisGina Cecilia Pistol0Daniela Eliza Marin1Mircea Catalin Rotar2Mariana Ropota3Ionelia Taranu4Laboratory of Animal Biology, INCDBNA-IBNA, National Institute of Research and Development for Biology and Animal Nutrition, Balotesti, Romania; Corresponding author.Laboratory of Animal Biology, INCDBNA-IBNA, National Institute of Research and Development for Biology and Animal Nutrition, Balotesti, RomaniaLaboratory of Animal Biology, INCDBNA-IBNA, National Institute of Research and Development for Biology and Animal Nutrition, Balotesti, RomaniaLaboratory of Chemistry and Nutrition Physiology, INCDBNA-IBNA, National Institute of Research and Development for Biology and Animal Nutrition, Balotesti, RomaniaLaboratory of Animal Biology, INCDBNA-IBNA, National Institute of Research and Development for Biology and Animal Nutrition, Balotesti, RomaniaThe management of Inflammatory Bowel Diseases symptoms is focused to find new alternative strategies which could have beneficial effects on intestinal inflammation including the nutritional interventions. Using an in vivo approach together with gene and protein analysis, we investigated the effect of a diet with 8% grape seed meal on inflammatory markers and signaling pathway molecules. DSS-challenged pigs were used as IBD animal model. Our results showed that the DSS treatment induced a widespread inflammation at colon level by increasing a wide range of pro-inflammatory molecules via activation of pro-inflammatory p38/ERK/JNK MAPK signaling cascades followed by activation of NF-kB and other nuclear receptors. Diet with grape seed meal was efficient in counteracting inflammatory disorders by inhibiting MAPKs, attenuating NF-kB gene and protein expression and diminishing pro-inflammatory cytokines and chemokines production toward the control level. Grape seed meal could be used as alternative food supplements to reduce inflammation at intestinal level.http://www.sciencedirect.com/science/article/pii/S1756464619306322IBDGrapeAnimal modelInflammatory markersSignaling molecules |
| spellingShingle | Gina Cecilia Pistol Daniela Eliza Marin Mircea Catalin Rotar Mariana Ropota Ionelia Taranu Bioactive compounds from dietary whole grape seed meal improved colonic inflammation via inhibition of MAPKs and NF-kB signaling in pigs with DSS induced colitis Journal of Functional Foods IBD Grape Animal model Inflammatory markers Signaling molecules |
| title | Bioactive compounds from dietary whole grape seed meal improved colonic inflammation via inhibition of MAPKs and NF-kB signaling in pigs with DSS induced colitis |
| title_full | Bioactive compounds from dietary whole grape seed meal improved colonic inflammation via inhibition of MAPKs and NF-kB signaling in pigs with DSS induced colitis |
| title_fullStr | Bioactive compounds from dietary whole grape seed meal improved colonic inflammation via inhibition of MAPKs and NF-kB signaling in pigs with DSS induced colitis |
| title_full_unstemmed | Bioactive compounds from dietary whole grape seed meal improved colonic inflammation via inhibition of MAPKs and NF-kB signaling in pigs with DSS induced colitis |
| title_short | Bioactive compounds from dietary whole grape seed meal improved colonic inflammation via inhibition of MAPKs and NF-kB signaling in pigs with DSS induced colitis |
| title_sort | bioactive compounds from dietary whole grape seed meal improved colonic inflammation via inhibition of mapks and nf kb signaling in pigs with dss induced colitis |
| topic | IBD Grape Animal model Inflammatory markers Signaling molecules |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619306322 |
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