Expression and function of the insulin receptor substrate proteins in cancer
<p>Abstract</p> <p>The Insulin Receptor Substrate (IRS) proteins are cytoplasmic adaptor proteins that function as essential signaling intermediates downstream of activated cell surface receptors, many of which have been implicated in cancer. The IRS proteins do not contain any int...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-06-01
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| Series: | Cell Communication and Signaling |
| Online Access: | http://www.biosignaling.com/content/7/1/14 |
| _version_ | 1818934542081196032 |
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| author | Pankratz Shannon L Mardilovich Katerina Shaw Leslie M |
| author_facet | Pankratz Shannon L Mardilovich Katerina Shaw Leslie M |
| author_sort | Pankratz Shannon L |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The Insulin Receptor Substrate (IRS) proteins are cytoplasmic adaptor proteins that function as essential signaling intermediates downstream of activated cell surface receptors, many of which have been implicated in cancer. The IRS proteins do not contain any intrinsic kinase activity, but rather serve as scaffolds to organize signaling complexes and initiate intracellular signaling pathways. As common intermediates of multiple receptors that can influence tumor progression, the IRS proteins are positioned to play a pivotal role in regulating the response of tumor cells to many different microenvironmental stimuli. Limited studies on IRS expression in human tumors and studies on IRS function in human tumor cell lines and in mouse models have provided clues to the potential function of these adaptor proteins in human cancer. A general theme arises from these studies; IRS-1 and IRS-4 are most often associated with tumor growth and proliferation and IRS-2 is most often associated with tumor motility and invasion. In this review, we discuss the mechanisms by which IRS expression and function are regulated and how the IRS proteins contribute to tumor initiation and progression.</p> |
| first_indexed | 2024-12-20T05:05:55Z |
| format | Article |
| id | doaj.art-60e1cf7e4bd14d8f8ba64cd10b2ead69 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-12-20T05:05:55Z |
| publishDate | 2009-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-60e1cf7e4bd14d8f8ba64cd10b2ead692022-12-21T19:52:23ZengBMCCell Communication and Signaling1478-811X2009-06-01711410.1186/1478-811X-7-14Expression and function of the insulin receptor substrate proteins in cancerPankratz Shannon LMardilovich KaterinaShaw Leslie M<p>Abstract</p> <p>The Insulin Receptor Substrate (IRS) proteins are cytoplasmic adaptor proteins that function as essential signaling intermediates downstream of activated cell surface receptors, many of which have been implicated in cancer. The IRS proteins do not contain any intrinsic kinase activity, but rather serve as scaffolds to organize signaling complexes and initiate intracellular signaling pathways. As common intermediates of multiple receptors that can influence tumor progression, the IRS proteins are positioned to play a pivotal role in regulating the response of tumor cells to many different microenvironmental stimuli. Limited studies on IRS expression in human tumors and studies on IRS function in human tumor cell lines and in mouse models have provided clues to the potential function of these adaptor proteins in human cancer. A general theme arises from these studies; IRS-1 and IRS-4 are most often associated with tumor growth and proliferation and IRS-2 is most often associated with tumor motility and invasion. In this review, we discuss the mechanisms by which IRS expression and function are regulated and how the IRS proteins contribute to tumor initiation and progression.</p>http://www.biosignaling.com/content/7/1/14 |
| spellingShingle | Pankratz Shannon L Mardilovich Katerina Shaw Leslie M Expression and function of the insulin receptor substrate proteins in cancer Cell Communication and Signaling |
| title | Expression and function of the insulin receptor substrate proteins in cancer |
| title_full | Expression and function of the insulin receptor substrate proteins in cancer |
| title_fullStr | Expression and function of the insulin receptor substrate proteins in cancer |
| title_full_unstemmed | Expression and function of the insulin receptor substrate proteins in cancer |
| title_short | Expression and function of the insulin receptor substrate proteins in cancer |
| title_sort | expression and function of the insulin receptor substrate proteins in cancer |
| url | http://www.biosignaling.com/content/7/1/14 |
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