Comparison of Adverse Events between Isolated Left Atrial Appendage Closure and Combined Catheter Ablation
(1) Background: This study aimed to investigate the effect of an additional catheter ablation (CA) procedure on the risk of post-procedure adverse events during CA combined with left atrial appendage closure (LAAC). (2) Methods: From July 2017 to February 2022, data from 361 patients with atrial fib...
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MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/5/1824 |
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| author | Yan Zhang Jing Yang Qian Liu Jinglan Wu Lei Yin Jing Lv Ling You Yanan Zhang Lianxia Wang Yanlei Zhao Qian Hou Weilin Jing Ruiqin Xie |
| author_facet | Yan Zhang Jing Yang Qian Liu Jinglan Wu Lei Yin Jing Lv Ling You Yanan Zhang Lianxia Wang Yanlei Zhao Qian Hou Weilin Jing Ruiqin Xie |
| author_sort | Yan Zhang |
| collection | DOAJ |
| description | (1) Background: This study aimed to investigate the effect of an additional catheter ablation (CA) procedure on the risk of post-procedure adverse events during CA combined with left atrial appendage closure (LAAC). (2) Methods: From July 2017 to February 2022, data from 361 patients with atrial fibrillation who underwent LAAC at our center were analyzed retrospectively. The adverse events were compared between CA + LAAC and LAAC-only groups. (3) Results: The incidence of device-related thrombus (DRT) and embolic events was significantly lower in the CA + LAAC group than in the LAAC-only group (<i>p</i> = 0.01 and 0.04, respectively). A logistic regression analysis revealed that the combined procedure served as a protective factor for DRT (OR = 0.09; 95% confidence interval: 0.01–0.89; <i>p</i> = 0.04). Based on a Cox regression analysis, the risk of embolism marginally increased in patients aged ≥65 years (HR = 7.49, 95% CI: 0.85–66.22 <i>p</i> = 0.07), whereas the combined procedure was found to be a protective factor (HR = 0.25, 95% CI: 0.07–0.87 <i>p</i> = 0.03). Further subgroup and interaction analyses revealed similar results. (4) Conclusions: The combined procedure may be associated with a lower rate of post-procedure DRT and embolization without a higher occurrence of other adverse events after LAAC. A risk-score-based prediction model was conducted, showing a good prediction performance. |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T07:20:34Z |
| publishDate | 2023-02-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-60e2046bbb02422b97fec457f91ec2ba2023-11-17T07:58:49ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01125182410.3390/jcm12051824Comparison of Adverse Events between Isolated Left Atrial Appendage Closure and Combined Catheter AblationYan Zhang0Jing Yang1Qian Liu2Jinglan Wu3Lei Yin4Jing Lv5Ling You6Yanan Zhang7Lianxia Wang8Yanlei Zhao9Qian Hou10Weilin Jing11Ruiqin Xie12First Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, ChinaFirst Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, ChinaFirst Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, ChinaSecond Department of Cardiac Ultrasound, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, ChinaFirst Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, ChinaFirst Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, ChinaFirst Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, ChinaFirst Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, ChinaFirst Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, ChinaFirst Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, ChinaFirst Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, ChinaFirst Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, ChinaFirst Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China(1) Background: This study aimed to investigate the effect of an additional catheter ablation (CA) procedure on the risk of post-procedure adverse events during CA combined with left atrial appendage closure (LAAC). (2) Methods: From July 2017 to February 2022, data from 361 patients with atrial fibrillation who underwent LAAC at our center were analyzed retrospectively. The adverse events were compared between CA + LAAC and LAAC-only groups. (3) Results: The incidence of device-related thrombus (DRT) and embolic events was significantly lower in the CA + LAAC group than in the LAAC-only group (<i>p</i> = 0.01 and 0.04, respectively). A logistic regression analysis revealed that the combined procedure served as a protective factor for DRT (OR = 0.09; 95% confidence interval: 0.01–0.89; <i>p</i> = 0.04). Based on a Cox regression analysis, the risk of embolism marginally increased in patients aged ≥65 years (HR = 7.49, 95% CI: 0.85–66.22 <i>p</i> = 0.07), whereas the combined procedure was found to be a protective factor (HR = 0.25, 95% CI: 0.07–0.87 <i>p</i> = 0.03). Further subgroup and interaction analyses revealed similar results. (4) Conclusions: The combined procedure may be associated with a lower rate of post-procedure DRT and embolization without a higher occurrence of other adverse events after LAAC. A risk-score-based prediction model was conducted, showing a good prediction performance.https://www.mdpi.com/2077-0383/12/5/1824atrial fibrillationpercutaneous left atrial appendage closurecatheter ablationpost-procedure adverse eventsmultivariate analysis |
| spellingShingle | Yan Zhang Jing Yang Qian Liu Jinglan Wu Lei Yin Jing Lv Ling You Yanan Zhang Lianxia Wang Yanlei Zhao Qian Hou Weilin Jing Ruiqin Xie Comparison of Adverse Events between Isolated Left Atrial Appendage Closure and Combined Catheter Ablation Journal of Clinical Medicine atrial fibrillation percutaneous left atrial appendage closure catheter ablation post-procedure adverse events multivariate analysis |
| title | Comparison of Adverse Events between Isolated Left Atrial Appendage Closure and Combined Catheter Ablation |
| title_full | Comparison of Adverse Events between Isolated Left Atrial Appendage Closure and Combined Catheter Ablation |
| title_fullStr | Comparison of Adverse Events between Isolated Left Atrial Appendage Closure and Combined Catheter Ablation |
| title_full_unstemmed | Comparison of Adverse Events between Isolated Left Atrial Appendage Closure and Combined Catheter Ablation |
| title_short | Comparison of Adverse Events between Isolated Left Atrial Appendage Closure and Combined Catheter Ablation |
| title_sort | comparison of adverse events between isolated left atrial appendage closure and combined catheter ablation |
| topic | atrial fibrillation percutaneous left atrial appendage closure catheter ablation post-procedure adverse events multivariate analysis |
| url | https://www.mdpi.com/2077-0383/12/5/1824 |
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