Tranilast inhibits TGF-β-induced collagen gel contraction mediated by human corneal fibroblasts

Tranilast inhibits TGF-β-induced collagen gel contraction mediated by human corneal fibroblasts

AIM: To determine if tranilast affects human corneal fibroblast (HCFs) contraction. METHODS: HCFs cultured in a three-dimensional type I collagen gel were treated with or without transforming growth factor beta (TGF-β) or tranilast. Gel diameter was measured as an indicator for collagen contraction...

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Bibliographic Details
Main Authors: Ye Liu, Xiao-Jing Zhao, Xiao-Shuo Zheng, Hui Zheng, Lei Liu, Ling-Bin Meng, Qin Li, Yang Liu
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2018-08-01
Series:International Journal of Ophthalmology
Subjects:
1252
tranilast
transforming growth factor beta
corneal fibroblast
corneal wound healing
Online Access:http://www.ijo.cn/en_publish/2018/8/20180801.pdf

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