Exploiting the Opportunity to Use Plant-Derived Nanoparticles as Delivery Vehicles
The scientific community has become increasingly interested in plant-derived nanoparticles (PDNPs) over the past ten years. Given that they possess all the benefits of a drug carrier, including non-toxicity, low immunogenicity, and a lipid bilayer that protects its content, PDNPs are a viable model...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/12/6/1207 |
| _version_ | 1797609424462807040 |
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| author | Vincenza Tinnirello Nima Rabienezhad Ganji Carine De Marcos Lousa Riccardo Alessandro Stefania Raimondo |
| author_facet | Vincenza Tinnirello Nima Rabienezhad Ganji Carine De Marcos Lousa Riccardo Alessandro Stefania Raimondo |
| author_sort | Vincenza Tinnirello |
| collection | DOAJ |
| description | The scientific community has become increasingly interested in plant-derived nanoparticles (PDNPs) over the past ten years. Given that they possess all the benefits of a drug carrier, including non-toxicity, low immunogenicity, and a lipid bilayer that protects its content, PDNPs are a viable model for the design of innovative delivery systems. In this review, a summary of the prerequisites for mammalian extracellular vesicles to serve as delivery vehicles will be given. After that, we will concentrate on providing a thorough overview of the studies investigating the interactions of plant-derived nanoparticles with mammalian systems as well as the loading strategies for encapsulating therapeutic molecules. Finally, the existing challenges in establishing PDNPs as reliable biological delivery systems will be emphasized. |
| first_indexed | 2024-03-11T06:01:10Z |
| format | Article |
| id | doaj.art-60e2f0901ee84659ad4fc598d4b9c25d |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-11T06:01:10Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-60e2f0901ee84659ad4fc598d4b9c25d2023-11-17T13:20:37ZengMDPI AGPlants2223-77472023-03-01126120710.3390/plants12061207Exploiting the Opportunity to Use Plant-Derived Nanoparticles as Delivery VehiclesVincenza Tinnirello0Nima Rabienezhad Ganji1Carine De Marcos Lousa2Riccardo Alessandro3Stefania Raimondo4Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, ItalyBiomedical Sciences, School of Health, Leeds Beckett University, Leeds LS1 3HE, UKDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, ItalyThe scientific community has become increasingly interested in plant-derived nanoparticles (PDNPs) over the past ten years. Given that they possess all the benefits of a drug carrier, including non-toxicity, low immunogenicity, and a lipid bilayer that protects its content, PDNPs are a viable model for the design of innovative delivery systems. In this review, a summary of the prerequisites for mammalian extracellular vesicles to serve as delivery vehicles will be given. After that, we will concentrate on providing a thorough overview of the studies investigating the interactions of plant-derived nanoparticles with mammalian systems as well as the loading strategies for encapsulating therapeutic molecules. Finally, the existing challenges in establishing PDNPs as reliable biological delivery systems will be emphasized.https://www.mdpi.com/2223-7747/12/6/1207plant-derived nanoparticles (PDNPs)drug deliveryco-incubationsonicationmicroRNA |
| spellingShingle | Vincenza Tinnirello Nima Rabienezhad Ganji Carine De Marcos Lousa Riccardo Alessandro Stefania Raimondo Exploiting the Opportunity to Use Plant-Derived Nanoparticles as Delivery Vehicles Plants plant-derived nanoparticles (PDNPs) drug delivery co-incubation sonication microRNA |
| title | Exploiting the Opportunity to Use Plant-Derived Nanoparticles as Delivery Vehicles |
| title_full | Exploiting the Opportunity to Use Plant-Derived Nanoparticles as Delivery Vehicles |
| title_fullStr | Exploiting the Opportunity to Use Plant-Derived Nanoparticles as Delivery Vehicles |
| title_full_unstemmed | Exploiting the Opportunity to Use Plant-Derived Nanoparticles as Delivery Vehicles |
| title_short | Exploiting the Opportunity to Use Plant-Derived Nanoparticles as Delivery Vehicles |
| title_sort | exploiting the opportunity to use plant derived nanoparticles as delivery vehicles |
| topic | plant-derived nanoparticles (PDNPs) drug delivery co-incubation sonication microRNA |
| url | https://www.mdpi.com/2223-7747/12/6/1207 |
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