Effects of vitamin D supplementation on metabolic parameters, serum irisin and obesity values in women with subclinical hypothyroidism: a double-blind randomized controlled trial
PurposeSubclinical hypothyroidism is an early, mild form of hypothyroidism that may progress to overt hypothyroidism if untreated. The current study aimed to assess the effects of vitamin D supplementation on hormonal (thyroid stimulating hormone [TSH], triiodothyronine, thyroxine, and free thyroxin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1306470/full |
| _version_ | 1797384212741881856 |
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| author | Sara Safari Sara Safari Maryam Rafraf Mahsa Malekian Roghayeh Molani-Gol Roghayeh Molani-Gol Mohammad Asghari-Jafarabadi Mohammad Asghari-Jafarabadi Majid Mobasseri |
| author_facet | Sara Safari Sara Safari Maryam Rafraf Mahsa Malekian Roghayeh Molani-Gol Roghayeh Molani-Gol Mohammad Asghari-Jafarabadi Mohammad Asghari-Jafarabadi Majid Mobasseri |
| author_sort | Sara Safari |
| collection | DOAJ |
| description | PurposeSubclinical hypothyroidism is an early, mild form of hypothyroidism that may progress to overt hypothyroidism if untreated. The current study aimed to assess the effects of vitamin D supplementation on hormonal (thyroid stimulating hormone [TSH], triiodothyronine, thyroxine, and free thyroxine) parameters, lipid profiles, serum irisin, and obesity indices in women with subclinical hypothyroidism.MethodsThe present randomized, double-blind, placebo-controlled clinical trial was carried out on 44 women with subclinical hypothyroidism. The participants were allocated to two groups (22 patients in each group) that received vitamin D (50,000 IU/week) or placebo for 12 weeks. Fasting blood samples, anthropometric and body composition measurements, physical activity levels, and dietary intakes were collected at baseline and at the end of the study.ResultsVitamin D supplementation significantly decreased TSH, total cholesterol, and fat mass percentage, and significantly increased serum vitamin D and irisin levels and fat-free mass percentage compared to the control group (all, p<0.05). Changes in thyroid hormones, other lipid profiles, and anthropometric indices were not significantly different between the groups.ConclusionOur study indicates that vitamin D administration improves serum TSH, total cholesterol, irisin, and body composition in women with subclinical hypothyroidism. More well-designed clinical trials are required to confirm these findings and clarify the effects of vitamin D supplementation on both genders of patients.Clinical trial registrationhttps://www.irct.ir/trial/57482, Identifier IRCT20100408003664N25. |
| first_indexed | 2024-03-08T21:32:10Z |
| format | Article |
| id | doaj.art-60e358207065404981943bd5498425d3 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T21:32:10Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-60e358207065404981943bd5498425d32023-12-21T04:50:10ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-12-011410.3389/fendo.2023.13064701306470Effects of vitamin D supplementation on metabolic parameters, serum irisin and obesity values in women with subclinical hypothyroidism: a double-blind randomized controlled trialSara Safari0Sara Safari1Maryam Rafraf2Mahsa Malekian3Roghayeh Molani-Gol4Roghayeh Molani-Gol5Mohammad Asghari-Jafarabadi6Mohammad Asghari-Jafarabadi7Majid Mobasseri8Student Research Committee, Tabriz University of Medical Sciences, Tabriz, IranNutrition Research Center, Department of Community Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, IranNutrition Research Center, Department of Community Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, IranEndocrine Research Center, Tabriz University of Medical Sciences, Tabriz, IranStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, IranNutrition Research Center, Department of Community Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, IranCabrini Research, Cabrini Health, Malvern, VIC, AustraliaSchool of Public Health and Preventative Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, AustraliaEndocrine Research Center, Tabriz University of Medical Sciences, Tabriz, IranPurposeSubclinical hypothyroidism is an early, mild form of hypothyroidism that may progress to overt hypothyroidism if untreated. The current study aimed to assess the effects of vitamin D supplementation on hormonal (thyroid stimulating hormone [TSH], triiodothyronine, thyroxine, and free thyroxine) parameters, lipid profiles, serum irisin, and obesity indices in women with subclinical hypothyroidism.MethodsThe present randomized, double-blind, placebo-controlled clinical trial was carried out on 44 women with subclinical hypothyroidism. The participants were allocated to two groups (22 patients in each group) that received vitamin D (50,000 IU/week) or placebo for 12 weeks. Fasting blood samples, anthropometric and body composition measurements, physical activity levels, and dietary intakes were collected at baseline and at the end of the study.ResultsVitamin D supplementation significantly decreased TSH, total cholesterol, and fat mass percentage, and significantly increased serum vitamin D and irisin levels and fat-free mass percentage compared to the control group (all, p<0.05). Changes in thyroid hormones, other lipid profiles, and anthropometric indices were not significantly different between the groups.ConclusionOur study indicates that vitamin D administration improves serum TSH, total cholesterol, irisin, and body composition in women with subclinical hypothyroidism. More well-designed clinical trials are required to confirm these findings and clarify the effects of vitamin D supplementation on both genders of patients.Clinical trial registrationhttps://www.irct.ir/trial/57482, Identifier IRCT20100408003664N25.https://www.frontiersin.org/articles/10.3389/fendo.2023.1306470/fullVitamin Dsubclinical hypothyroidismTSHmetabolic parametersirisinobesity |
| spellingShingle | Sara Safari Sara Safari Maryam Rafraf Mahsa Malekian Roghayeh Molani-Gol Roghayeh Molani-Gol Mohammad Asghari-Jafarabadi Mohammad Asghari-Jafarabadi Majid Mobasseri Effects of vitamin D supplementation on metabolic parameters, serum irisin and obesity values in women with subclinical hypothyroidism: a double-blind randomized controlled trial Frontiers in Endocrinology Vitamin D subclinical hypothyroidism TSH metabolic parameters irisin obesity |
| title | Effects of vitamin D supplementation on metabolic parameters, serum irisin and obesity values in women with subclinical hypothyroidism: a double-blind randomized controlled trial |
| title_full | Effects of vitamin D supplementation on metabolic parameters, serum irisin and obesity values in women with subclinical hypothyroidism: a double-blind randomized controlled trial |
| title_fullStr | Effects of vitamin D supplementation on metabolic parameters, serum irisin and obesity values in women with subclinical hypothyroidism: a double-blind randomized controlled trial |
| title_full_unstemmed | Effects of vitamin D supplementation on metabolic parameters, serum irisin and obesity values in women with subclinical hypothyroidism: a double-blind randomized controlled trial |
| title_short | Effects of vitamin D supplementation on metabolic parameters, serum irisin and obesity values in women with subclinical hypothyroidism: a double-blind randomized controlled trial |
| title_sort | effects of vitamin d supplementation on metabolic parameters serum irisin and obesity values in women with subclinical hypothyroidism a double blind randomized controlled trial |
| topic | Vitamin D subclinical hypothyroidism TSH metabolic parameters irisin obesity |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1306470/full |
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