Body weight, gonadectomy, and other risk factors for diagnosis of osteoarthritis in companion dogs
ObjectiveThe aim of this study is to evaluate age, sex, body weight, breed, neuter status, and age at neutering as risk factors for diagnosis of osteoarthritis in companion dogs.AnimalsDogs seen as patients at Banfield Pet Hospital in the United States from 1998 to 2019 with a date of death in 2019....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Veterinary Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2023.1275964/full |
| _version_ | 1797449283832643584 |
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| author | Jessica L. Graves Brennen A. McKenzie Zane Koch Alexander Naka Nathaniel Spofford JoAnn Morrison |
| author_facet | Jessica L. Graves Brennen A. McKenzie Zane Koch Alexander Naka Nathaniel Spofford JoAnn Morrison |
| author_sort | Jessica L. Graves |
| collection | DOAJ |
| description | ObjectiveThe aim of this study is to evaluate age, sex, body weight, breed, neuter status, and age at neutering as risk factors for diagnosis of osteoarthritis in companion dogs.AnimalsDogs seen as patients at Banfield Pet Hospital in the United States from 1998 to 2019 with a date of death in 2019. The final cohort consisted of 131,140 dogs.MethodsIn this retrospective cohort study, Cox proportional hazard models were used to test for associations between osteoarthritis incidence and age at baseline, sex, maximum body weight, maximum body condition score, neuter status, and age at neutering. The same model was used to test these associations in 12 representative breeds, chosen based on breed weight and sample size.ResultsOlder age, higher adult body weight, gonadectomy, and younger age at gonadectomy were significantly associated with higher risks of osteoarthritis in the total cohort and in all 12 breeds evaluated. Higher body condition scores and sex were also significantly associated with osteoarthritis but with minimal effect sizes in the overall cohort, and these risk factors were not consistently significant in all breeds tested.Clinical relevanceThese results will assist veterinarians in identifying dogs at higher risk for osteoarthritis and applying appropriate diagnostic, preventative, and treatment interventions. An understanding of potentially modifiable risk factors, such as body condition and neutering, will support evidence-based discussions with dog owners about risk management in individual patients. |
| first_indexed | 2024-03-09T14:23:33Z |
| format | Article |
| id | doaj.art-60e3973395e448fba23132e394e70eae |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-03-09T14:23:33Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-60e3973395e448fba23132e394e70eae2023-11-28T08:19:14ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692023-11-011010.3389/fvets.2023.12759641275964Body weight, gonadectomy, and other risk factors for diagnosis of osteoarthritis in companion dogsJessica L. Graves0Brennen A. McKenzie1Zane Koch2Alexander Naka3Nathaniel Spofford4JoAnn Morrison5Loyal, San Francisco, CA, United StatesLoyal, San Francisco, CA, United StatesLoyal, San Francisco, CA, United StatesLoyal, San Francisco, CA, United StatesBanfield Pet Hospital, Portland, OR, United StatesBanfield Pet Hospital, Portland, OR, United StatesObjectiveThe aim of this study is to evaluate age, sex, body weight, breed, neuter status, and age at neutering as risk factors for diagnosis of osteoarthritis in companion dogs.AnimalsDogs seen as patients at Banfield Pet Hospital in the United States from 1998 to 2019 with a date of death in 2019. The final cohort consisted of 131,140 dogs.MethodsIn this retrospective cohort study, Cox proportional hazard models were used to test for associations between osteoarthritis incidence and age at baseline, sex, maximum body weight, maximum body condition score, neuter status, and age at neutering. The same model was used to test these associations in 12 representative breeds, chosen based on breed weight and sample size.ResultsOlder age, higher adult body weight, gonadectomy, and younger age at gonadectomy were significantly associated with higher risks of osteoarthritis in the total cohort and in all 12 breeds evaluated. Higher body condition scores and sex were also significantly associated with osteoarthritis but with minimal effect sizes in the overall cohort, and these risk factors were not consistently significant in all breeds tested.Clinical relevanceThese results will assist veterinarians in identifying dogs at higher risk for osteoarthritis and applying appropriate diagnostic, preventative, and treatment interventions. An understanding of potentially modifiable risk factors, such as body condition and neutering, will support evidence-based discussions with dog owners about risk management in individual patients.https://www.frontiersin.org/articles/10.3389/fvets.2023.1275964/fulldogsosteoarthritisdegenerative joint disease (DJD)risk factorsincidence |
| spellingShingle | Jessica L. Graves Brennen A. McKenzie Zane Koch Alexander Naka Nathaniel Spofford JoAnn Morrison Body weight, gonadectomy, and other risk factors for diagnosis of osteoarthritis in companion dogs Frontiers in Veterinary Science dogs osteoarthritis degenerative joint disease (DJD) risk factors incidence |
| title | Body weight, gonadectomy, and other risk factors for diagnosis of osteoarthritis in companion dogs |
| title_full | Body weight, gonadectomy, and other risk factors for diagnosis of osteoarthritis in companion dogs |
| title_fullStr | Body weight, gonadectomy, and other risk factors for diagnosis of osteoarthritis in companion dogs |
| title_full_unstemmed | Body weight, gonadectomy, and other risk factors for diagnosis of osteoarthritis in companion dogs |
| title_short | Body weight, gonadectomy, and other risk factors for diagnosis of osteoarthritis in companion dogs |
| title_sort | body weight gonadectomy and other risk factors for diagnosis of osteoarthritis in companion dogs |
| topic | dogs osteoarthritis degenerative joint disease (DJD) risk factors incidence |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2023.1275964/full |
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