Striatal Aβ peptide deposition mirrors dementia and differentiates DLB and PDD from other Parkinsonian syndromes
Recent neuropathological studies have described widespread amyloid-β peptide (Aβ) deposition in the striatum of patients with Lewy body disorders, particularly in Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB). However, positron emission tomography (PET) studies usi...
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| Format: | Article |
| Language: | English |
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Elsevier
2011-02-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996110003396 |
| _version_ | 1818350604325486592 |
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| author | M.E. Kalaitzakis A.J. Walls R.K.B. Pearce S.M. Gentleman |
| author_facet | M.E. Kalaitzakis A.J. Walls R.K.B. Pearce S.M. Gentleman |
| author_sort | M.E. Kalaitzakis |
| collection | DOAJ |
| description | Recent neuropathological studies have described widespread amyloid-β peptide (Aβ) deposition in the striatum of patients with Lewy body disorders, particularly in Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB). However, positron emission tomography (PET) studies using the [11C]PIB ligand, binding to Aβ deposits, detects significant striatal pathology only in DLB and not in PDD. Employing immunohistochemistry, we examined striatal Aβ deposition in the caudate nucleus and putamen of 52 PD, 41 PDD, 14 DLB, 7 multiple system atrophy (MSA) and 14 progressive supranuclear palsy (PSP) cases in relation to the presence of dementia. PD, MSA and PSP cases showed little or no Aβ pathology in the striatum. In contrast, both PDD and DLB cases demonstrated significantly greater Aβ deposition in the striatum when compared to PD, MSA and PSP groups. We conclude that striatal Aβ pathology is common in both PDD and DLB and may reflect the development of dementia in these conditions. More detailed examination of the morphology of the Aβ pathology suggests that it is the presence of cored amyloid plaques in DLB, but not PDD, that underlies the differences seen in PET imaging. |
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| format | Article |
| id | doaj.art-60e3a33e5fc74a8698e05d549d1af1fb |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-13T18:24:29Z |
| publishDate | 2011-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-60e3a33e5fc74a8698e05d549d1af1fb2022-12-21T23:35:38ZengElsevierNeurobiology of Disease1095-953X2011-02-01412377384Striatal Aβ peptide deposition mirrors dementia and differentiates DLB and PDD from other Parkinsonian syndromesM.E. Kalaitzakis0A.J. Walls1R.K.B. Pearce2S.M. Gentleman3Corresponding author.; Neuropathology Unit, Centre for Neuroscience, Division of Experimental Medicine, Department of Medicine, Imperial College London, Charing Cross Campus, St Dunstan's Road, London, UK, W6 8RPNeuropathology Unit, Centre for Neuroscience, Division of Experimental Medicine, Department of Medicine, Imperial College London, Charing Cross Campus, St Dunstan's Road, London, UK, W6 8RPNeuropathology Unit, Centre for Neuroscience, Division of Experimental Medicine, Department of Medicine, Imperial College London, Charing Cross Campus, St Dunstan's Road, London, UK, W6 8RPNeuropathology Unit, Centre for Neuroscience, Division of Experimental Medicine, Department of Medicine, Imperial College London, Charing Cross Campus, St Dunstan's Road, London, UK, W6 8RPRecent neuropathological studies have described widespread amyloid-β peptide (Aβ) deposition in the striatum of patients with Lewy body disorders, particularly in Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB). However, positron emission tomography (PET) studies using the [11C]PIB ligand, binding to Aβ deposits, detects significant striatal pathology only in DLB and not in PDD. Employing immunohistochemistry, we examined striatal Aβ deposition in the caudate nucleus and putamen of 52 PD, 41 PDD, 14 DLB, 7 multiple system atrophy (MSA) and 14 progressive supranuclear palsy (PSP) cases in relation to the presence of dementia. PD, MSA and PSP cases showed little or no Aβ pathology in the striatum. In contrast, both PDD and DLB cases demonstrated significantly greater Aβ deposition in the striatum when compared to PD, MSA and PSP groups. We conclude that striatal Aβ pathology is common in both PDD and DLB and may reflect the development of dementia in these conditions. More detailed examination of the morphology of the Aβ pathology suggests that it is the presence of cored amyloid plaques in DLB, but not PDD, that underlies the differences seen in PET imaging.http://www.sciencedirect.com/science/article/pii/S0969996110003396Parkinson's diseaseDementiaStriatumAmyloid-β peptide[11C]PIB ligandDementia with Lewy bodies |
| spellingShingle | M.E. Kalaitzakis A.J. Walls R.K.B. Pearce S.M. Gentleman Striatal Aβ peptide deposition mirrors dementia and differentiates DLB and PDD from other Parkinsonian syndromes Neurobiology of Disease Parkinson's disease Dementia Striatum Amyloid-β peptide [11C]PIB ligand Dementia with Lewy bodies |
| title | Striatal Aβ peptide deposition mirrors dementia and differentiates DLB and PDD from other Parkinsonian syndromes |
| title_full | Striatal Aβ peptide deposition mirrors dementia and differentiates DLB and PDD from other Parkinsonian syndromes |
| title_fullStr | Striatal Aβ peptide deposition mirrors dementia and differentiates DLB and PDD from other Parkinsonian syndromes |
| title_full_unstemmed | Striatal Aβ peptide deposition mirrors dementia and differentiates DLB and PDD from other Parkinsonian syndromes |
| title_short | Striatal Aβ peptide deposition mirrors dementia and differentiates DLB and PDD from other Parkinsonian syndromes |
| title_sort | striatal aβ peptide deposition mirrors dementia and differentiates dlb and pdd from other parkinsonian syndromes |
| topic | Parkinson's disease Dementia Striatum Amyloid-β peptide [11C]PIB ligand Dementia with Lewy bodies |
| url | http://www.sciencedirect.com/science/article/pii/S0969996110003396 |
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