Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil
ABSTRACT Objectives To assess the evolution to permanent or transient conditions in children with positive neonatal TSH tests in Sergipe, Brazil, from 2004 to 2010. Subjects and methods Out of 193,794 screened newborns, 713 presented a neonatal TSH level higher than the local cutoff (5.2 µU/mL)....
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
2016-08-01
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| Series: | Archives of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000500450&lng=en&tlng=en |
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| author | Diana M. Matos Roberto J. R. Ramalho Bruno M. Carvalho Maria Augusta C. T. Almeida Luciana F. D. Passos Talmay T. S. Vasconcelos Enaldo V. Melo Carla R. P. Oliveira Elenilde G. Santos Karla F. Resende Manuel H. Aguiar-Oliveira |
| author_facet | Diana M. Matos Roberto J. R. Ramalho Bruno M. Carvalho Maria Augusta C. T. Almeida Luciana F. D. Passos Talmay T. S. Vasconcelos Enaldo V. Melo Carla R. P. Oliveira Elenilde G. Santos Karla F. Resende Manuel H. Aguiar-Oliveira |
| author_sort | Diana M. Matos |
| collection | DOAJ |
| description | ABSTRACT Objectives To assess the evolution to permanent or transient conditions in children with positive neonatal TSH tests in Sergipe, Brazil, from 2004 to 2010. Subjects and methods Out of 193,794 screened newborns, 713 presented a neonatal TSH level higher than the local cutoff (5.2 µU/mL). From the confirmatory serum TSH values, the children were diagnosed with initial congenital hypothyroidism (CH) or suspect CH. From the evolution, they were classified as permanent CH, hyperthyrotropinemia, or transient TSH elevation. The mean incidence of each final condition was calculated for the total period of time. Results The initial diagnosis included 37 CH (18.1%) and 167 suspect CH (81.9%) cases. The final diagnosis included 46 cases of permanent CH (22.5%), 56 of hyperthyrotropinemia (27.5%), and 102 of transient TSH elevation (50.0%). Out of the 37 cases of initial CH, 23 (62.2%) had permanent CH, nine (24.3%) had hyperthyrotropinemia, and five (13.5%) had transient TSH elevation. Out of the 167 suspect CH cases, 23 (13.8%) had permanent CH, 47 (28.1%) had hyperthyrotropinemia and 97 (58.1%) had transient TSH elevation. The mean incidence after the follow up was 1:4,166 for permanent CH, 1:3,448 for hyperthyrotropinemia, and 1:1,887 for transient TSH elevation. Eighty-six percent of the children with an initial diagnosis of CH and 41.9% with suspect CH had a permanent condition (CH or hyperthyrotropinemia). Conclusions The follow-up of children with an initial diagnosis of CH or suspect CH is necessary to determine whether the disorder is permanent because predicting the evolution of the condition is difficult. |
| first_indexed | 2024-12-14T00:09:23Z |
| format | Article |
| id | doaj.art-60e3c0c7d5cb4a44bc48f2dfafbefe05 |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-12-14T00:09:23Z |
| publishDate | 2016-08-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-60e3c0c7d5cb4a44bc48f2dfafbefe052022-12-21T23:25:49ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922016-08-0160545045610.1590/2359-3997000000189S2359-39972016000500450Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, BrazilDiana M. MatosRoberto J. R. RamalhoBruno M. CarvalhoMaria Augusta C. T. AlmeidaLuciana F. D. PassosTalmay T. S. VasconcelosEnaldo V. MeloCarla R. P. OliveiraElenilde G. SantosKarla F. ResendeManuel H. Aguiar-OliveiraABSTRACT Objectives To assess the evolution to permanent or transient conditions in children with positive neonatal TSH tests in Sergipe, Brazil, from 2004 to 2010. Subjects and methods Out of 193,794 screened newborns, 713 presented a neonatal TSH level higher than the local cutoff (5.2 µU/mL). From the confirmatory serum TSH values, the children were diagnosed with initial congenital hypothyroidism (CH) or suspect CH. From the evolution, they were classified as permanent CH, hyperthyrotropinemia, or transient TSH elevation. The mean incidence of each final condition was calculated for the total period of time. Results The initial diagnosis included 37 CH (18.1%) and 167 suspect CH (81.9%) cases. The final diagnosis included 46 cases of permanent CH (22.5%), 56 of hyperthyrotropinemia (27.5%), and 102 of transient TSH elevation (50.0%). Out of the 37 cases of initial CH, 23 (62.2%) had permanent CH, nine (24.3%) had hyperthyrotropinemia, and five (13.5%) had transient TSH elevation. Out of the 167 suspect CH cases, 23 (13.8%) had permanent CH, 47 (28.1%) had hyperthyrotropinemia and 97 (58.1%) had transient TSH elevation. The mean incidence after the follow up was 1:4,166 for permanent CH, 1:3,448 for hyperthyrotropinemia, and 1:1,887 for transient TSH elevation. Eighty-six percent of the children with an initial diagnosis of CH and 41.9% with suspect CH had a permanent condition (CH or hyperthyrotropinemia). Conclusions The follow-up of children with an initial diagnosis of CH or suspect CH is necessary to determine whether the disorder is permanent because predicting the evolution of the condition is difficult.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000500450&lng=en&tlng=enNeonatal screeningcongenital hypothyroidismthyrotropinthyroid hormones |
| spellingShingle | Diana M. Matos Roberto J. R. Ramalho Bruno M. Carvalho Maria Augusta C. T. Almeida Luciana F. D. Passos Talmay T. S. Vasconcelos Enaldo V. Melo Carla R. P. Oliveira Elenilde G. Santos Karla F. Resende Manuel H. Aguiar-Oliveira Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil Archives of Endocrinology and Metabolism Neonatal screening congenital hypothyroidism thyrotropin thyroid hormones |
| title | Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil |
| title_full | Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil |
| title_fullStr | Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil |
| title_full_unstemmed | Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil |
| title_short | Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil |
| title_sort | evolution to permanent or transient conditions in children with positive neonatal tsh screening tests in sergipe brazil |
| topic | Neonatal screening congenital hypothyroidism thyrotropin thyroid hormones |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000500450&lng=en&tlng=en |
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