Serum folate concentration and the incidence of lung cancer.
Lung cancer is a leading cause of cancer-related mortality globally. Folate helps to maintain DNA integrity and to regulate gene expression. Serum folate levels may affect the risk of several cancers, including lung cancer. In this study we evaluated the association between serum folate concentratio...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5426769?pdf=render |
| _version_ | 1818300870850248704 |
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| author | Katarzyna Durda Krzysztof Kąklewski Satish Gupta Michał Szydłowski Piotr Baszuk Katarzyna Jaworska-Bieniek Grzegorz Sukiennicki Katarzyna Kaczmarek Piotr Waloszczyk Steven Narod Jan Lubiński Anna Jakubowska |
| author_facet | Katarzyna Durda Krzysztof Kąklewski Satish Gupta Michał Szydłowski Piotr Baszuk Katarzyna Jaworska-Bieniek Grzegorz Sukiennicki Katarzyna Kaczmarek Piotr Waloszczyk Steven Narod Jan Lubiński Anna Jakubowska |
| author_sort | Katarzyna Durda |
| collection | DOAJ |
| description | Lung cancer is a leading cause of cancer-related mortality globally. Folate helps to maintain DNA integrity and to regulate gene expression. Serum folate levels may affect the risk of several cancers, including lung cancer. In this study we evaluated the association between serum folate concentration and variations in genes involved in folate metabolism with lung cancer incidence in Poland.The study included 366 lung cancer patients and 366 control subjects. We measured serum folate concentration and genotyped six variants in MTHFR, MTR and MTRR genes. The odds ratios of being diagnosed with lung cancer were calculated using conditional univariable and multivariable logistic regression with respect to folate level and genotypes.The mean serum folate level was lower in lung cancer cases than in control group (20.07 nmol/l vs. 22.52 nmol/l, p = 0.002). The odds ratio for lung cancer declined with increasing serum content of the folate. The folate concentration of >25.71 nmol/l (IVth quartile) in comparison to <15.92 nmol/l (Ist quartile) was associated with an odds ratio of 0.61 (95%CI 0.40-0.95, p = 0.03). The analysis of variations in MTHFR, MTR and MTRR genes did not reveal any significant difference between lung cancer cases and controls in univariable and multivariable analyses.In this case-control study, lower serum folate concentrations were associated with a higher risk of lung cancer diagnosis. Although previous findings have been somewhat mixed, our results add to the evidence that circulating folate levels may be an indicator of lung cancer risk. |
| first_indexed | 2024-12-13T05:14:00Z |
| format | Article |
| id | doaj.art-60e48f7b091b443ea551ea21e72aae08 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T05:14:00Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-60e48f7b091b443ea551ea21e72aae082022-12-21T23:58:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01125e017744110.1371/journal.pone.0177441Serum folate concentration and the incidence of lung cancer.Katarzyna DurdaKrzysztof KąklewskiSatish GuptaMichał SzydłowskiPiotr BaszukKatarzyna Jaworska-BieniekGrzegorz SukiennickiKatarzyna KaczmarekPiotr WaloszczykSteven NarodJan LubińskiAnna JakubowskaLung cancer is a leading cause of cancer-related mortality globally. Folate helps to maintain DNA integrity and to regulate gene expression. Serum folate levels may affect the risk of several cancers, including lung cancer. In this study we evaluated the association between serum folate concentration and variations in genes involved in folate metabolism with lung cancer incidence in Poland.The study included 366 lung cancer patients and 366 control subjects. We measured serum folate concentration and genotyped six variants in MTHFR, MTR and MTRR genes. The odds ratios of being diagnosed with lung cancer were calculated using conditional univariable and multivariable logistic regression with respect to folate level and genotypes.The mean serum folate level was lower in lung cancer cases than in control group (20.07 nmol/l vs. 22.52 nmol/l, p = 0.002). The odds ratio for lung cancer declined with increasing serum content of the folate. The folate concentration of >25.71 nmol/l (IVth quartile) in comparison to <15.92 nmol/l (Ist quartile) was associated with an odds ratio of 0.61 (95%CI 0.40-0.95, p = 0.03). The analysis of variations in MTHFR, MTR and MTRR genes did not reveal any significant difference between lung cancer cases and controls in univariable and multivariable analyses.In this case-control study, lower serum folate concentrations were associated with a higher risk of lung cancer diagnosis. Although previous findings have been somewhat mixed, our results add to the evidence that circulating folate levels may be an indicator of lung cancer risk.http://europepmc.org/articles/PMC5426769?pdf=render |
| spellingShingle | Katarzyna Durda Krzysztof Kąklewski Satish Gupta Michał Szydłowski Piotr Baszuk Katarzyna Jaworska-Bieniek Grzegorz Sukiennicki Katarzyna Kaczmarek Piotr Waloszczyk Steven Narod Jan Lubiński Anna Jakubowska Serum folate concentration and the incidence of lung cancer. PLoS ONE |
| title | Serum folate concentration and the incidence of lung cancer. |
| title_full | Serum folate concentration and the incidence of lung cancer. |
| title_fullStr | Serum folate concentration and the incidence of lung cancer. |
| title_full_unstemmed | Serum folate concentration and the incidence of lung cancer. |
| title_short | Serum folate concentration and the incidence of lung cancer. |
| title_sort | serum folate concentration and the incidence of lung cancer |
| url | http://europepmc.org/articles/PMC5426769?pdf=render |
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