Host heterogeneity and epistasis explain punctuated evolution of SARS-CoV-2.
Identifying drivers of viral diversity is key to understanding the evolutionary as well as epidemiological dynamics of the COVID-19 pandemic. Using rich viral genomic data sets, we show that periods of steadily rising diversity have been punctuated by sudden, enormous increases followed by similarly...
Main Authors: | Bjarke Frost Nielsen, Chadi M Saad-Roy, Yimei Li, Kim Sneppen, Lone Simonsen, Cécile Viboud, Simon A Levin, Bryan T Grenfell |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2023-02-01
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Series: | PLoS Computational Biology |
Online Access: | https://doi.org/10.1371/journal.pcbi.1010896 |
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