Roles of Mast Cells in Cutaneous Diseases
Mast cells are present in all vascularized tissues of the body. They are especially abundant in tissues that are in frequent contact with the surrounding environment and act as potential sources of inflammatory and/or regulatory mediators during development of various infections and diseases. Mature...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.923495/full |
| _version_ | 1811316273373511680 |
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| author | Takafumi Numata Kazutoshi Harada Susumu Nakae Susumu Nakae |
| author_facet | Takafumi Numata Kazutoshi Harada Susumu Nakae Susumu Nakae |
| author_sort | Takafumi Numata |
| collection | DOAJ |
| description | Mast cells are present in all vascularized tissues of the body. They are especially abundant in tissues that are in frequent contact with the surrounding environment and act as potential sources of inflammatory and/or regulatory mediators during development of various infections and diseases. Mature mast cells’ cytoplasm contains numerous granules that store a variety of chemical mediators, cytokines, proteoglycans, and proteases. Mast cells are activated via various cell surface receptors, including FcϵRI, toll-like receptors (TLR), Mas-related G-protein-coupled receptor X2 (MRGPRX2), and cytokine receptors. IgE-mediated mast cell activation results in release of histamine and other contents of their granules into the extracellular environment, contributing to host defense against pathogens. TLRs, play a crucial role in host defense against various types of pathogens by recognizing pathogen-associated molecular patterns. On the other hand, excessive/inappropriate mast cell activation can cause various disorders. Here, we review the published literature regarding the known and potential inflammatory and regulatory roles of mast cells in cutaneous inflammation, including atopic dermatitis, psoriasis, and contact dermatitis GVHD, as well as in host defense against pathogens. |
| first_indexed | 2024-04-13T11:45:56Z |
| format | Article |
| id | doaj.art-60ee5a6fa3cf4963a3d2ed9c22661025 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T11:45:56Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-60ee5a6fa3cf4963a3d2ed9c226610252022-12-22T02:48:10ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-07-011310.3389/fimmu.2022.923495923495Roles of Mast Cells in Cutaneous DiseasesTakafumi Numata0Kazutoshi Harada1Susumu Nakae2Susumu Nakae3Department of Dermatology, Tokyo Medical University, Tokyo, JapanDepartment of Dermatology, Tokyo Medical University, Tokyo, JapanGraduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima, JapanPrecursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Saitama, JapanMast cells are present in all vascularized tissues of the body. They are especially abundant in tissues that are in frequent contact with the surrounding environment and act as potential sources of inflammatory and/or regulatory mediators during development of various infections and diseases. Mature mast cells’ cytoplasm contains numerous granules that store a variety of chemical mediators, cytokines, proteoglycans, and proteases. Mast cells are activated via various cell surface receptors, including FcϵRI, toll-like receptors (TLR), Mas-related G-protein-coupled receptor X2 (MRGPRX2), and cytokine receptors. IgE-mediated mast cell activation results in release of histamine and other contents of their granules into the extracellular environment, contributing to host defense against pathogens. TLRs, play a crucial role in host defense against various types of pathogens by recognizing pathogen-associated molecular patterns. On the other hand, excessive/inappropriate mast cell activation can cause various disorders. Here, we review the published literature regarding the known and potential inflammatory and regulatory roles of mast cells in cutaneous inflammation, including atopic dermatitis, psoriasis, and contact dermatitis GVHD, as well as in host defense against pathogens.https://www.frontiersin.org/articles/10.3389/fimmu.2022.923495/fullskin diseaseallergyautoimmunityinfectionrejection |
| spellingShingle | Takafumi Numata Kazutoshi Harada Susumu Nakae Susumu Nakae Roles of Mast Cells in Cutaneous Diseases Frontiers in Immunology skin disease allergy autoimmunity infection rejection |
| title | Roles of Mast Cells in Cutaneous Diseases |
| title_full | Roles of Mast Cells in Cutaneous Diseases |
| title_fullStr | Roles of Mast Cells in Cutaneous Diseases |
| title_full_unstemmed | Roles of Mast Cells in Cutaneous Diseases |
| title_short | Roles of Mast Cells in Cutaneous Diseases |
| title_sort | roles of mast cells in cutaneous diseases |
| topic | skin disease allergy autoimmunity infection rejection |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.923495/full |
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