Clinical, epidemiological, and virological features of Mpox in Beijing, China – May 31–June 21, 2023
ABSTRACTThe first locally acquired case in the Chinese mainland was reported on May 31, 2023, lagging behind other countries. In this study, we aimed to examine the early clinical and epidemiological characteristics of the earliest cases of Mpox in Beijing, China. Additionally, we investigated the s...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2254407 |
| _version_ | 1797257053051289600 |
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| author | Xiangfeng Dou Fu Li Zhenyong Ren Daitao Zhang Jia Li Dan Li Yulan Sun Haoyuan Jin Renqing Li Weihong Li Xin Zhang Yang Yang Lei Jia Yu Han Wai Li Yang Pan Wenjie Tan Peng Yang Quanyi Wang |
| author_facet | Xiangfeng Dou Fu Li Zhenyong Ren Daitao Zhang Jia Li Dan Li Yulan Sun Haoyuan Jin Renqing Li Weihong Li Xin Zhang Yang Yang Lei Jia Yu Han Wai Li Yang Pan Wenjie Tan Peng Yang Quanyi Wang |
| author_sort | Xiangfeng Dou |
| collection | DOAJ |
| description | ABSTRACTThe first locally acquired case in the Chinese mainland was reported on May 31, 2023, lagging behind other countries. In this study, we aimed to examine the early clinical and epidemiological characteristics of the earliest cases of Mpox in Beijing, China. Additionally, we investigated the sequence and transmission patterns of the Mpox virus (MPXV). We analyzed 37 reported cases of Mpox in Beijing from May 31, 2023 to June 21, 2023. The age range of the subjects was 24–51 years. Thirty-six cases (97.3%) were identified in men who have sex with men (MSM), and 19 cases (51.4%) tested positive for the human immunodeficiency virus. Thirty-three cases were symptomatic, while four were asymptomatic. Skin lesions were observed in 32 cases (97.0%), fever in 26 (78.8%), and swollen lymph nodes in 17 (51.5%). Rash typically appeared in the genital or perianal area 1–3 days before fever onset, with a minimum incubation period of 2 days. For individuals with skin rashes, the skin lesion samples showed 100% positivity and low Ct values. There were high oropharyngeal swab (75.8%) and blood (84.6%) positivity rates. All MPXV strains belonged to the B.1.3 branch of the West African lineage. These strains carried 76–86 nucleotide substitutions compared with the reference human MPXV genome, and genetic diversity was observed. Our findings provide the first insights into the landscape of early transmission of Mpox in Beijing and help inform policy formulation in the Chinese mainland. |
| first_indexed | 2024-03-08T11:51:22Z |
| format | Article |
| id | doaj.art-60ee63ddaeec496aae428a369fa90718 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-04-24T22:31:31Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-60ee63ddaeec496aae428a369fa907182024-03-19T19:34:17ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512023-12-0112210.1080/22221751.2023.2254407Clinical, epidemiological, and virological features of Mpox in Beijing, China – May 31–June 21, 2023Xiangfeng Dou0Fu Li1Zhenyong Ren2Daitao Zhang3Jia Li4Dan Li5Yulan Sun6Haoyuan Jin7Renqing Li8Weihong Li9Xin Zhang10Yang Yang11Lei Jia12Yu Han13Wai Li14Yang Pan15Wenjie Tan16Peng Yang17Quanyi Wang18Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaInstitute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaInstitute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaInstitute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaInstitute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaInstitute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaInstitute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaInstitute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaInstitute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaInstitute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaInstitute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaInstitute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaInstitute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaDepartment of Dermatology, Civil Aviation General Hospital, Beijing, People’s Republic of ChinaBeijing Fangshan District Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaInstitute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaInstitute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaInstitute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of ChinaABSTRACTThe first locally acquired case in the Chinese mainland was reported on May 31, 2023, lagging behind other countries. In this study, we aimed to examine the early clinical and epidemiological characteristics of the earliest cases of Mpox in Beijing, China. Additionally, we investigated the sequence and transmission patterns of the Mpox virus (MPXV). We analyzed 37 reported cases of Mpox in Beijing from May 31, 2023 to June 21, 2023. The age range of the subjects was 24–51 years. Thirty-six cases (97.3%) were identified in men who have sex with men (MSM), and 19 cases (51.4%) tested positive for the human immunodeficiency virus. Thirty-three cases were symptomatic, while four were asymptomatic. Skin lesions were observed in 32 cases (97.0%), fever in 26 (78.8%), and swollen lymph nodes in 17 (51.5%). Rash typically appeared in the genital or perianal area 1–3 days before fever onset, with a minimum incubation period of 2 days. For individuals with skin rashes, the skin lesion samples showed 100% positivity and low Ct values. There were high oropharyngeal swab (75.8%) and blood (84.6%) positivity rates. All MPXV strains belonged to the B.1.3 branch of the West African lineage. These strains carried 76–86 nucleotide substitutions compared with the reference human MPXV genome, and genetic diversity was observed. Our findings provide the first insights into the landscape of early transmission of Mpox in Beijing and help inform policy formulation in the Chinese mainland.https://www.tandfonline.com/doi/10.1080/22221751.2023.2254407MpoxMPXVnext generation sequencingmen who have sex with menChina |
| spellingShingle | Xiangfeng Dou Fu Li Zhenyong Ren Daitao Zhang Jia Li Dan Li Yulan Sun Haoyuan Jin Renqing Li Weihong Li Xin Zhang Yang Yang Lei Jia Yu Han Wai Li Yang Pan Wenjie Tan Peng Yang Quanyi Wang Clinical, epidemiological, and virological features of Mpox in Beijing, China – May 31–June 21, 2023 Emerging Microbes and Infections Mpox MPXV next generation sequencing men who have sex with men China |
| title | Clinical, epidemiological, and virological features of Mpox in Beijing, China – May 31–June 21, 2023 |
| title_full | Clinical, epidemiological, and virological features of Mpox in Beijing, China – May 31–June 21, 2023 |
| title_fullStr | Clinical, epidemiological, and virological features of Mpox in Beijing, China – May 31–June 21, 2023 |
| title_full_unstemmed | Clinical, epidemiological, and virological features of Mpox in Beijing, China – May 31–June 21, 2023 |
| title_short | Clinical, epidemiological, and virological features of Mpox in Beijing, China – May 31–June 21, 2023 |
| title_sort | clinical epidemiological and virological features of mpox in beijing china may 31 june 21 2023 |
| topic | Mpox MPXV next generation sequencing men who have sex with men China |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2254407 |
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