Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics
The fluidic barrier in centrifugal microfluidic platforms is a newly introduced concept for making multiple emulsions and microparticles. In this study, we focused on particle generation application to better characterize this method. Because the phenomenon is too fast to be captured experimentally,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/13/6/881 |
| _version_ | 1797484331575279616 |
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| author | Masoud Madadelahi Javid Azimi-Boulali Marc Madou Sergio Omar Martinez-Chapa |
| author_facet | Masoud Madadelahi Javid Azimi-Boulali Marc Madou Sergio Omar Martinez-Chapa |
| author_sort | Masoud Madadelahi |
| collection | DOAJ |
| description | The fluidic barrier in centrifugal microfluidic platforms is a newly introduced concept for making multiple emulsions and microparticles. In this study, we focused on particle generation application to better characterize this method. Because the phenomenon is too fast to be captured experimentally, we employ theoretical models to show how liquid polymeric droplets pass a fluidic barrier before crosslinking. We explain how secondary flows evolve and mix the fluids within the droplets. From an experimental point of view, the effect of different parameters, such as the barrier length, source channel width, and rotational speed, on the particles’ size and aspect ratio are investigated. It is demonstrated that the barrier length does not affect the particle’s ultimate velocity. Unlike conventional air gaps, the barrier length does not significantly affect the aspect ratio of the produced microparticles. Eventually, we broaden this concept to two source fluids and study the importance of source channel geometry, barrier length, and rotational speed in generating two-fluid droplets. |
| first_indexed | 2024-03-09T23:01:58Z |
| format | Article |
| id | doaj.art-60ee686ae49d4540a51e599dff27c94c |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-09T23:01:58Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-60ee686ae49d4540a51e599dff27c94c2023-11-23T18:00:57ZengMDPI AGMicromachines2072-666X2022-05-0113688110.3390/mi13060881Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal MicrofluidicsMasoud Madadelahi0Javid Azimi-Boulali1Marc Madou2Sergio Omar Martinez-Chapa3School of Engineering and Sciences, Tecnológico de Monterrey, Ave. Eugenio Garza Sada 2501, Monterrey 64849, NL, MexicoSchool of Engineering and Sciences, Tecnológico de Monterrey, Ave. Eugenio Garza Sada 2501, Monterrey 64849, NL, MexicoDepartment of Mechanical and Aerospace Engineering, University of California Irvine, Irvine, CA 92697, USASchool of Engineering and Sciences, Tecnológico de Monterrey, Ave. Eugenio Garza Sada 2501, Monterrey 64849, NL, MexicoThe fluidic barrier in centrifugal microfluidic platforms is a newly introduced concept for making multiple emulsions and microparticles. In this study, we focused on particle generation application to better characterize this method. Because the phenomenon is too fast to be captured experimentally, we employ theoretical models to show how liquid polymeric droplets pass a fluidic barrier before crosslinking. We explain how secondary flows evolve and mix the fluids within the droplets. From an experimental point of view, the effect of different parameters, such as the barrier length, source channel width, and rotational speed, on the particles’ size and aspect ratio are investigated. It is demonstrated that the barrier length does not affect the particle’s ultimate velocity. Unlike conventional air gaps, the barrier length does not significantly affect the aspect ratio of the produced microparticles. Eventually, we broaden this concept to two source fluids and study the importance of source channel geometry, barrier length, and rotational speed in generating two-fluid droplets.https://www.mdpi.com/2072-666X/13/6/881fluidic barriercentrifugal microfluidicsdroplet generationalginate microparticlethree-phase model |
| spellingShingle | Masoud Madadelahi Javid Azimi-Boulali Marc Madou Sergio Omar Martinez-Chapa Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics Micromachines fluidic barrier centrifugal microfluidics droplet generation alginate microparticle three-phase model |
| title | Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics |
| title_full | Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics |
| title_fullStr | Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics |
| title_full_unstemmed | Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics |
| title_short | Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics |
| title_sort | characterization of fluidic barrier based particle generation in centrifugal microfluidics |
| topic | fluidic barrier centrifugal microfluidics droplet generation alginate microparticle three-phase model |
| url | https://www.mdpi.com/2072-666X/13/6/881 |
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