APE1 Promotes Pancreatic Cancer Proliferation through GFRα1/Src/ERK Axis-Cascade Signaling in Response to GDNF

APE1 Promotes Pancreatic Cancer Proliferation through GFRα1/Src/ERK Axis-Cascade Signaling in Response to GDNF

Pancreatic cancer is the worst exocrine gastrointestinal cancer leading to the highest mortality. Recent studies reported that aberrant expression of apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) is involved in uncontrolled cell growth. However, the molecular mechanism of APE1 biological role...

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Bibliographic Details
Main Authors: Yoo-Duk Choi, Ji-Yeon Jung, Minwoo Baek, Sheema Khan, Peter I. Song, Sunhyo Ryu, Joo-Yeon Koo, Subhash C. Chauhan, Andrew Tsin, Chan Choi, Won Jae Kim, Mihwa Kim
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
APE1
GFRα1
Src/ERK
pancreatic cancer
proliferation
Online Access:https://www.mdpi.com/1422-0067/21/10/3586

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