The Role of Nutraceutical Supplements, Monacolin K and Astaxanthin, and Diet in Blood Cholesterol Homeostasis in Patients with Myopathy
Several studies suggest that different combinations of nutraceutical supplements may improve the lipid profile, representing a viable alternative to statins. However, their effects on individuals with myopathy need to be investigated. The aim of our study was to explore the mid- and long-term physio...
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MDPI AG
2022-08-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/8/1118 |
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| author | Ines Villano Marco La Marra Salvatore Allocca Ciro Rosario Ilardi Rita Polito Chiara Porro Sergio Chieffi Giovanni Messina Vincenzo Monda Girolamo Di Maio Antonietta Messina |
| author_facet | Ines Villano Marco La Marra Salvatore Allocca Ciro Rosario Ilardi Rita Polito Chiara Porro Sergio Chieffi Giovanni Messina Vincenzo Monda Girolamo Di Maio Antonietta Messina |
| author_sort | Ines Villano |
| collection | DOAJ |
| description | Several studies suggest that different combinations of nutraceutical supplements may improve the lipid profile, representing a viable alternative to statins. However, their effects on individuals with myopathy need to be investigated. The aim of our study was to explore the mid- and long-term physiological effects of monacolin k (5 mg) and astaxanthin (0.1 mg) supplements in association with a low-energy/fat diet in a group of subjects with mild myopathy. Eighty subjects (44 women) took part in this observational study. Participants were assigned to the experimental group (EG, <i>n</i> = 40, 24 women) treated with a low-energy/fat diet (1200–1500 Kcal/day and 15–20% lipids) in combination with monacolin k (5 mg) and astaxanthin (0.1 mg) supplementation, and to the control group (CG, <i>n</i> = 40, 20 women) treated only with a low-energy/fat diet (1200–1500 Kcal/day and 15–20% lipids). BMI and biochemical parameters (blood glucose, total cholesterol, HDL, LDL, triglycerides, C-reactive protein (CRP) and creatine phosphokinase-CPK) were collected at baseline (T0), after 12 (T1) and 24 (T2) weeks. A mixed factorial ANOVA was performed to determine if there were significant main effects and/or interactions between time and treatment. Treatment (EG vs. CG) was entered as the between-subjects factor and time (T0 vs. T1 vs. T2) as the within-subject factor. We found a significant improvement in total cholesterol, HDL, LDL, PCR and CPK parameters in EG compared with CG. Our results highlight the efficacy and safety of combined use of monacolin k (5 mg) and astaxanthin (0.1 mg) in combination with a low-energy/fat diet in the treatment of dyslipidemia. |
| first_indexed | 2024-03-09T10:00:24Z |
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| id | doaj.art-60f0778cfa1e41469175427ffd3265c6 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T10:00:24Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-60f0778cfa1e41469175427ffd3265c62023-12-01T23:29:15ZengMDPI AGBiomolecules2218-273X2022-08-01128111810.3390/biom12081118The Role of Nutraceutical Supplements, Monacolin K and Astaxanthin, and Diet in Blood Cholesterol Homeostasis in Patients with MyopathyInes Villano0Marco La Marra1Salvatore Allocca2Ciro Rosario Ilardi3Rita Polito4Chiara Porro5Sergio Chieffi6Giovanni Messina7Vincenzo Monda8Girolamo Di Maio9Antonietta Messina10Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Psychology, University of Campania “Luigi Vanvitelli”, 81100 Caserta, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, ItalyDepartment of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, ItalyDepartment of Movement Sciences and Wellbeing, University of Naples “Parthenope”, 80138 Naples, ItalyDepartment of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalySeveral studies suggest that different combinations of nutraceutical supplements may improve the lipid profile, representing a viable alternative to statins. However, their effects on individuals with myopathy need to be investigated. The aim of our study was to explore the mid- and long-term physiological effects of monacolin k (5 mg) and astaxanthin (0.1 mg) supplements in association with a low-energy/fat diet in a group of subjects with mild myopathy. Eighty subjects (44 women) took part in this observational study. Participants were assigned to the experimental group (EG, <i>n</i> = 40, 24 women) treated with a low-energy/fat diet (1200–1500 Kcal/day and 15–20% lipids) in combination with monacolin k (5 mg) and astaxanthin (0.1 mg) supplementation, and to the control group (CG, <i>n</i> = 40, 20 women) treated only with a low-energy/fat diet (1200–1500 Kcal/day and 15–20% lipids). BMI and biochemical parameters (blood glucose, total cholesterol, HDL, LDL, triglycerides, C-reactive protein (CRP) and creatine phosphokinase-CPK) were collected at baseline (T0), after 12 (T1) and 24 (T2) weeks. A mixed factorial ANOVA was performed to determine if there were significant main effects and/or interactions between time and treatment. Treatment (EG vs. CG) was entered as the between-subjects factor and time (T0 vs. T1 vs. T2) as the within-subject factor. We found a significant improvement in total cholesterol, HDL, LDL, PCR and CPK parameters in EG compared with CG. Our results highlight the efficacy and safety of combined use of monacolin k (5 mg) and astaxanthin (0.1 mg) in combination with a low-energy/fat diet in the treatment of dyslipidemia.https://www.mdpi.com/2218-273X/12/8/1118monacolin kastaxanthinantioxidantcholesteroldietdietary supplement |
| spellingShingle | Ines Villano Marco La Marra Salvatore Allocca Ciro Rosario Ilardi Rita Polito Chiara Porro Sergio Chieffi Giovanni Messina Vincenzo Monda Girolamo Di Maio Antonietta Messina The Role of Nutraceutical Supplements, Monacolin K and Astaxanthin, and Diet in Blood Cholesterol Homeostasis in Patients with Myopathy Biomolecules monacolin k astaxanthin antioxidant cholesterol diet dietary supplement |
| title | The Role of Nutraceutical Supplements, Monacolin K and Astaxanthin, and Diet in Blood Cholesterol Homeostasis in Patients with Myopathy |
| title_full | The Role of Nutraceutical Supplements, Monacolin K and Astaxanthin, and Diet in Blood Cholesterol Homeostasis in Patients with Myopathy |
| title_fullStr | The Role of Nutraceutical Supplements, Monacolin K and Astaxanthin, and Diet in Blood Cholesterol Homeostasis in Patients with Myopathy |
| title_full_unstemmed | The Role of Nutraceutical Supplements, Monacolin K and Astaxanthin, and Diet in Blood Cholesterol Homeostasis in Patients with Myopathy |
| title_short | The Role of Nutraceutical Supplements, Monacolin K and Astaxanthin, and Diet in Blood Cholesterol Homeostasis in Patients with Myopathy |
| title_sort | role of nutraceutical supplements monacolin k and astaxanthin and diet in blood cholesterol homeostasis in patients with myopathy |
| topic | monacolin k astaxanthin antioxidant cholesterol diet dietary supplement |
| url | https://www.mdpi.com/2218-273X/12/8/1118 |
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