Arsenic exposure affects plasma insulin-like growth factor 1 (IGF-1) in children in rural Bangladesh.
BACKGROUND: Exposure to inorganic arsenic (As) through drinking water during pregnancy is associated with lower birth size and child growth. The aim of the study was to assess the effects of As exposure on child growth parameters to evaluate causal associations. METHODOLOGY/FINDINGS: Children born i...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3841153?pdf=render |
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| author | Sultan Ahmed Rokeya Sultana Rekha Khalid Bin Ahsan Mariko Doi Margaretha Grandér Anjan Kumar Roy Eva-Charlotte Ekström Yukiko Wagatsuma Marie Vahter Rubhana Raqib |
| author_facet | Sultan Ahmed Rokeya Sultana Rekha Khalid Bin Ahsan Mariko Doi Margaretha Grandér Anjan Kumar Roy Eva-Charlotte Ekström Yukiko Wagatsuma Marie Vahter Rubhana Raqib |
| author_sort | Sultan Ahmed |
| collection | DOAJ |
| description | BACKGROUND: Exposure to inorganic arsenic (As) through drinking water during pregnancy is associated with lower birth size and child growth. The aim of the study was to assess the effects of As exposure on child growth parameters to evaluate causal associations. METHODOLOGY/FINDINGS: Children born in a longitudinal mother-child cohort in rural Bangladesh were studied at 4.5 years (n=640) as well as at birth (n=134). Exposure to arsenic was assessed by concurrent and prenatal (maternal) urinary concentrations of arsenic metabolites (U-As). Associations with plasma concentrations of insulin-like growth factor 1 (IGF-1), calcium (Ca), vitamin D (Vit-D), bone-specific alkaline phosphatase (B-ALP), intact parathyroid hormone (iPTH), and phosphate (PO4) were evaluated by linear regression analysis, adjusted for socioeconomic factor, parity and child sex. Child U-As (per 10 µg/L) was significantly inversely associated with concurrent plasma IGF-1 (β=-0.27; 95% confidence interval: -0.50, -0.0042) at 4.5 years. The effect was more obvious in girls (β=-0.29; -0.59, 0.021) than in boys, and particularly in girls with adequate height (β=-0.491; -0.97, -0.02) or weight (β=-0.47; 0.97, 0.01). Maternal U-As was inversely associated with child IGF-1 at birth (r=-0.254, P=0.003), but not at 4.5 years. There was a tendency of positive association between U-As and plasma PO4 in stunted boys (β=0.27; 0.089, 0.46). When stratified by % monomethylarsonic acid (MMA, arsenic metabolite) (median split at 9.7%), a much stronger inverse association between U-As and IGF-1 in the girls (β=-0.41; -0.77, -0.03) was obtained above the median split. CONCLUSION: The results suggest that As-related growth impairment in children is mediated, at least partly, through suppressed IGF-1 levels. |
| first_indexed | 2024-12-11T08:37:40Z |
| format | Article |
| id | doaj.art-60f1805ecd9c43aaaaf5b1aa7949553a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T08:37:40Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-60f1805ecd9c43aaaaf5b1aa7949553a2022-12-22T01:14:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01811e8153010.1371/journal.pone.0081530Arsenic exposure affects plasma insulin-like growth factor 1 (IGF-1) in children in rural Bangladesh.Sultan AhmedRokeya Sultana RekhaKhalid Bin AhsanMariko DoiMargaretha GrandérAnjan Kumar RoyEva-Charlotte EkströmYukiko WagatsumaMarie VahterRubhana RaqibBACKGROUND: Exposure to inorganic arsenic (As) through drinking water during pregnancy is associated with lower birth size and child growth. The aim of the study was to assess the effects of As exposure on child growth parameters to evaluate causal associations. METHODOLOGY/FINDINGS: Children born in a longitudinal mother-child cohort in rural Bangladesh were studied at 4.5 years (n=640) as well as at birth (n=134). Exposure to arsenic was assessed by concurrent and prenatal (maternal) urinary concentrations of arsenic metabolites (U-As). Associations with plasma concentrations of insulin-like growth factor 1 (IGF-1), calcium (Ca), vitamin D (Vit-D), bone-specific alkaline phosphatase (B-ALP), intact parathyroid hormone (iPTH), and phosphate (PO4) were evaluated by linear regression analysis, adjusted for socioeconomic factor, parity and child sex. Child U-As (per 10 µg/L) was significantly inversely associated with concurrent plasma IGF-1 (β=-0.27; 95% confidence interval: -0.50, -0.0042) at 4.5 years. The effect was more obvious in girls (β=-0.29; -0.59, 0.021) than in boys, and particularly in girls with adequate height (β=-0.491; -0.97, -0.02) or weight (β=-0.47; 0.97, 0.01). Maternal U-As was inversely associated with child IGF-1 at birth (r=-0.254, P=0.003), but not at 4.5 years. There was a tendency of positive association between U-As and plasma PO4 in stunted boys (β=0.27; 0.089, 0.46). When stratified by % monomethylarsonic acid (MMA, arsenic metabolite) (median split at 9.7%), a much stronger inverse association between U-As and IGF-1 in the girls (β=-0.41; -0.77, -0.03) was obtained above the median split. CONCLUSION: The results suggest that As-related growth impairment in children is mediated, at least partly, through suppressed IGF-1 levels.http://europepmc.org/articles/PMC3841153?pdf=render |
| spellingShingle | Sultan Ahmed Rokeya Sultana Rekha Khalid Bin Ahsan Mariko Doi Margaretha Grandér Anjan Kumar Roy Eva-Charlotte Ekström Yukiko Wagatsuma Marie Vahter Rubhana Raqib Arsenic exposure affects plasma insulin-like growth factor 1 (IGF-1) in children in rural Bangladesh. PLoS ONE |
| title | Arsenic exposure affects plasma insulin-like growth factor 1 (IGF-1) in children in rural Bangladesh. |
| title_full | Arsenic exposure affects plasma insulin-like growth factor 1 (IGF-1) in children in rural Bangladesh. |
| title_fullStr | Arsenic exposure affects plasma insulin-like growth factor 1 (IGF-1) in children in rural Bangladesh. |
| title_full_unstemmed | Arsenic exposure affects plasma insulin-like growth factor 1 (IGF-1) in children in rural Bangladesh. |
| title_short | Arsenic exposure affects plasma insulin-like growth factor 1 (IGF-1) in children in rural Bangladesh. |
| title_sort | arsenic exposure affects plasma insulin like growth factor 1 igf 1 in children in rural bangladesh |
| url | http://europepmc.org/articles/PMC3841153?pdf=render |
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