Whole-transcriptome analysis of aluminum-exposed rat hippocampus and identification of ceRNA networks to investigate neurotoxicity of Al

Whole-transcriptome analysis of aluminum-exposed rat hippocampus and identification of ceRNA networks to investigate neurotoxicity of Al

Aluminum is a known neurotoxin that can induce Aβ deposition and abnormal phosphorylation of tau protein, leading to Alzheimer disease (AD)-like damages such as neuronal damage and decreased learning and memory functions. In this study, we constructed a rat model of subchronic aluminum maltol exposu...

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Bibliographic Details
Main Authors: Chanting He, Xiaoyan Zhao, Yang Lei, Jisheng Nie, Xiaoting Lu, Jing Song, Linping Wang, Huan Li, Fangqu Liu, Yidan Zhang, Qiao Niu
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
aluminum
RNA sequencing
ceRNA
PI3K/AKT pathway
IRS1
miR-96-5p
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121002857

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