Vinpocetine, a Phosphodiesterase Type 1 Inhibitor, Mitigates Locomotor Hyperactivity in Female Mice Exposed to Lead During Development

Vinpocetine, a Phosphodiesterase Type 1 Inhibitor, Mitigates Locomotor Hyperactivity in Female Mice Exposed to Lead During Development

Background/Objectives Studies in rodents indicate that disruptions in both cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) signaling pathways are involved in the development of hyperactive behavior. We examined whether vinpocetine, a phosphodiesterase type 1 inhibitor...

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Bibliographic Details
Main Authors: Ulisses C. Araujo, Fernanda Nunes, Bruno S. Gonçalves, Regina A. A. Gomes, Maria de Fátima R. Moreira, Andre Nunes-Freitas, Thomas E. Krahe, Yael de Abreu-Villaça, Alex C. Manhães, Cláudio C. Filgueiras
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Brain Sciences
Subjects:
locomotor hyperactivity
heavy metal
cyclic nucleotides
type 1 phosphodiesterase
Online Access:https://www.mdpi.com/2076-3425/15/2/150

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https://www.mdpi.com/2076-3425/15/2/150

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