Regulation and therapeutic potentials of microRNAs to non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for 80%–85% of total cases and leading to millions of deaths worldwide. Drug resistance is the primary cause of treatment failure in NSCLC, which urges scientists to develop advanced approaches for NSCLC treatment....
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023092885 |
| _version_ | 1797429690707738624 |
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| author | Mai Thi Le Huyen-Thu Nguyen Xuan-Hung Nguyen Xuan-Hai Do Binh Thanh Mai Ha Thi Ngoc Nguyen Uyen Thi Trang Than Thanh-Hong Nguyen |
| author_facet | Mai Thi Le Huyen-Thu Nguyen Xuan-Hung Nguyen Xuan-Hai Do Binh Thanh Mai Ha Thi Ngoc Nguyen Uyen Thi Trang Than Thanh-Hong Nguyen |
| author_sort | Mai Thi Le |
| collection | DOAJ |
| description | Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for 80%–85% of total cases and leading to millions of deaths worldwide. Drug resistance is the primary cause of treatment failure in NSCLC, which urges scientists to develop advanced approaches for NSCLC treatment. Among novel approaches, the miRNA-based method has emerged as a potential approach as it allows researchers to modulate target gene expression. Subsequently, cell behaviors are altered, which leads to the death and the depletion of cancer cells. It has been reported that miRNAs possess the capacity to regulate multiple genes that are involved in various signaling pathways, including the phosphoinositide 3-kinase, receptor tyrosine kinase/rat sarcoma virus/mitogen-activated protein kinase, wingless/integrated, retinoblastoma, p53, transforming growth factor β, and nuclear factor-kappa B pathways. Dysregulation of these signaling pathways in NSCLC results in abnormal cell proliferation, tissue invasion, and drug resistance while inhibiting apoptosis. Thus, understanding the roles of miRNAs in regulating these signaling pathways may enable the development of novel NSCLC treatment therapies. However, a comprehensive review of potential miRNAs in NSCLC treatment has been lacking. Therefore, this review aims to fill the gap by summarizing the up-to-date information on miRNAs regarding their targets, impact on cancer-associated pathways, and prospective outcomes in treating NSCLC. We also discuss current technologies for delivering miRNAs to the target cells, including virus-based, non-viral, and emerging extracellular vesicle-based delivery systems. This knowledge will support future studies to develop an innovative miRNA-based therapy and select a suitable carrier to treat NSCLC effectively. |
| first_indexed | 2024-03-09T09:17:47Z |
| format | Article |
| id | doaj.art-60f6dbc09536486290145735578bd5b8 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-09T09:17:47Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-60f6dbc09536486290145735578bd5b82023-12-02T07:05:07ZengElsevierHeliyon2405-84402023-11-01911e22080Regulation and therapeutic potentials of microRNAs to non-small cell lung cancerMai Thi Le0Huyen-Thu Nguyen1Xuan-Hung Nguyen2Xuan-Hai Do3Binh Thanh Mai4Ha Thi Ngoc Nguyen5Uyen Thi Trang Than6Thanh-Hong Nguyen7Vinmec Hi-tech Center, Vinmec Healthcare System, Hanoi, 100000, Viet Nam; Faculty of Biology, VNU University of Science, Vietnam National University, Hanoi, 100000, Viet NamVinmec Hi-tech Center, Vinmec Healthcare System, Hanoi, 100000, Viet NamVinmec Hi-tech Center, Vinmec Healthcare System, Hanoi, 100000, Viet Nam; College of Health Sciences, Vin University, Hanoi, 100000, Viet Nam; Vinmec-VinUni Institute of Immunology, Vinmec Healthcare System, Hanoi, 100000, Viet NamDepartment of Gastroenterology, 108 Military Central Hospital, Hanoi, Viet NamDepartment of Practical and Experimental Surgery, Vietnam Military Medical University, 160 Phung Hung Street, Phuc La, Ha Dong, Hanoi, Viet NamVinmec Hi-tech Center, Vinmec Healthcare System, Hanoi, 100000, Viet NamVinmec Hi-tech Center, Vinmec Healthcare System, Hanoi, 100000, Viet Nam; Vinmec-VinUni Institute of Immunology, Vinmec Healthcare System, Hanoi, 100000, Viet Nam; Corresponding author. Vinmec Hi-tech Center, Vinmec Healthcare System, Hanoi, 100000, Viet Nam.Vinmec Hi-tech Center, Vinmec Healthcare System, Hanoi, 100000, Viet Nam; Corresponding author.Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for 80%–85% of total cases and leading to millions of deaths worldwide. Drug resistance is the primary cause of treatment failure in NSCLC, which urges scientists to develop advanced approaches for NSCLC treatment. Among novel approaches, the miRNA-based method has emerged as a potential approach as it allows researchers to modulate target gene expression. Subsequently, cell behaviors are altered, which leads to the death and the depletion of cancer cells. It has been reported that miRNAs possess the capacity to regulate multiple genes that are involved in various signaling pathways, including the phosphoinositide 3-kinase, receptor tyrosine kinase/rat sarcoma virus/mitogen-activated protein kinase, wingless/integrated, retinoblastoma, p53, transforming growth factor β, and nuclear factor-kappa B pathways. Dysregulation of these signaling pathways in NSCLC results in abnormal cell proliferation, tissue invasion, and drug resistance while inhibiting apoptosis. Thus, understanding the roles of miRNAs in regulating these signaling pathways may enable the development of novel NSCLC treatment therapies. However, a comprehensive review of potential miRNAs in NSCLC treatment has been lacking. Therefore, this review aims to fill the gap by summarizing the up-to-date information on miRNAs regarding their targets, impact on cancer-associated pathways, and prospective outcomes in treating NSCLC. We also discuss current technologies for delivering miRNAs to the target cells, including virus-based, non-viral, and emerging extracellular vesicle-based delivery systems. This knowledge will support future studies to develop an innovative miRNA-based therapy and select a suitable carrier to treat NSCLC effectively.http://www.sciencedirect.com/science/article/pii/S2405844023092885miRNAsNon-small cell lung cancermiRNA-based therapymiRNA delivery systems |
| spellingShingle | Mai Thi Le Huyen-Thu Nguyen Xuan-Hung Nguyen Xuan-Hai Do Binh Thanh Mai Ha Thi Ngoc Nguyen Uyen Thi Trang Than Thanh-Hong Nguyen Regulation and therapeutic potentials of microRNAs to non-small cell lung cancer Heliyon miRNAs Non-small cell lung cancer miRNA-based therapy miRNA delivery systems |
| title | Regulation and therapeutic potentials of microRNAs to non-small cell lung cancer |
| title_full | Regulation and therapeutic potentials of microRNAs to non-small cell lung cancer |
| title_fullStr | Regulation and therapeutic potentials of microRNAs to non-small cell lung cancer |
| title_full_unstemmed | Regulation and therapeutic potentials of microRNAs to non-small cell lung cancer |
| title_short | Regulation and therapeutic potentials of microRNAs to non-small cell lung cancer |
| title_sort | regulation and therapeutic potentials of micrornas to non small cell lung cancer |
| topic | miRNAs Non-small cell lung cancer miRNA-based therapy miRNA delivery systems |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023092885 |
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