Dynamic CD8<sup>+</sup> T Cell Cooperation with Macrophages and Monocytes for Successful Cancer Immunotherapy
The essential roles endorsed by macrophages and monocytes are well established in response to infections, where they contribute to launching the differentiation of specific T-lymphocytes for long-term protection. This knowledge is the result of dynamic studies that can inspire the cancer field, part...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/14/3546 |
| _version_ | 1797433732662034432 |
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| author | Anaïs Vermare Marion V. Guérin Elisa Peranzoni Nadège Bercovici |
| author_facet | Anaïs Vermare Marion V. Guérin Elisa Peranzoni Nadège Bercovici |
| author_sort | Anaïs Vermare |
| collection | DOAJ |
| description | The essential roles endorsed by macrophages and monocytes are well established in response to infections, where they contribute to launching the differentiation of specific T-lymphocytes for long-term protection. This knowledge is the result of dynamic studies that can inspire the cancer field, particularly now that cancer immunotherapies elicit some tumor regression. Indeed, immune responses to cancer have mainly been studied after tumors have escaped immune attacks. In particular, the suppressive functions of macrophages were revealed in this context, introducing an obvious bias across the literature. In this review, we will focus on the ways inwhich monocytes and macrophages cooperate with T-lymphocytes, leading to successful immune responses. We will bring together the preclinical studies that have revealed the existence of such positive cooperation in the cancer field, and we will place particular emphasis on proposing the underlying mechanisms. Finally, we will give some perspectives to decipher the functional roles of such T-cell and myeloid cell interactions in the frame of human cancer immunotherapy. |
| first_indexed | 2024-03-09T10:21:13Z |
| format | Article |
| id | doaj.art-60f79b06f3564c7a9f44a92e0d9c26f7 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T10:21:13Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-60f79b06f3564c7a9f44a92e0d9c26f72023-12-01T21:59:57ZengMDPI AGCancers2072-66942022-07-011414354610.3390/cancers14143546Dynamic CD8<sup>+</sup> T Cell Cooperation with Macrophages and Monocytes for Successful Cancer ImmunotherapyAnaïs Vermare0Marion V. Guérin1Elisa Peranzoni2Nadège Bercovici3Université Paris Cité, Institut Cochin, INSERM, CNRS, F-75014 Paris, FranceInstitut Pasteur, INSERM, 75724 Paris CEDEX 15, FranceIstituto Oncologico Veneto IOV—IRCCS, 35128 Padova, ItalyUniversité Paris Cité, Institut Cochin, INSERM, CNRS, F-75014 Paris, FranceThe essential roles endorsed by macrophages and monocytes are well established in response to infections, where they contribute to launching the differentiation of specific T-lymphocytes for long-term protection. This knowledge is the result of dynamic studies that can inspire the cancer field, particularly now that cancer immunotherapies elicit some tumor regression. Indeed, immune responses to cancer have mainly been studied after tumors have escaped immune attacks. In particular, the suppressive functions of macrophages were revealed in this context, introducing an obvious bias across the literature. In this review, we will focus on the ways inwhich monocytes and macrophages cooperate with T-lymphocytes, leading to successful immune responses. We will bring together the preclinical studies that have revealed the existence of such positive cooperation in the cancer field, and we will place particular emphasis on proposing the underlying mechanisms. Finally, we will give some perspectives to decipher the functional roles of such T-cell and myeloid cell interactions in the frame of human cancer immunotherapy.https://www.mdpi.com/2072-6694/14/14/3546T cellsmacrophagesmonocytescell–cell interactionsdynamic cooperationinterferons |
| spellingShingle | Anaïs Vermare Marion V. Guérin Elisa Peranzoni Nadège Bercovici Dynamic CD8<sup>+</sup> T Cell Cooperation with Macrophages and Monocytes for Successful Cancer Immunotherapy Cancers T cells macrophages monocytes cell–cell interactions dynamic cooperation interferons |
| title | Dynamic CD8<sup>+</sup> T Cell Cooperation with Macrophages and Monocytes for Successful Cancer Immunotherapy |
| title_full | Dynamic CD8<sup>+</sup> T Cell Cooperation with Macrophages and Monocytes for Successful Cancer Immunotherapy |
| title_fullStr | Dynamic CD8<sup>+</sup> T Cell Cooperation with Macrophages and Monocytes for Successful Cancer Immunotherapy |
| title_full_unstemmed | Dynamic CD8<sup>+</sup> T Cell Cooperation with Macrophages and Monocytes for Successful Cancer Immunotherapy |
| title_short | Dynamic CD8<sup>+</sup> T Cell Cooperation with Macrophages and Monocytes for Successful Cancer Immunotherapy |
| title_sort | dynamic cd8 sup sup t cell cooperation with macrophages and monocytes for successful cancer immunotherapy |
| topic | T cells macrophages monocytes cell–cell interactions dynamic cooperation interferons |
| url | https://www.mdpi.com/2072-6694/14/14/3546 |
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