Physical Modeling of a Sliding Clamp Mechanism for the Spreading of ParB at Short Genomic Distance from Bacterial Centromere Sites

Physical Modeling of a Sliding Clamp Mechanism for the Spreading of ParB at Short Genomic Distance from Bacterial Centromere Sites

Summary: Bacterial ParB partitioning proteins involved in chromosomes and low-copy-number plasmid segregation are cytosine triphosphate (CTP)-dependent molecular switches. CTP-binding converts ParB dimers to DNA clamps, allowing unidimensional diffusion along the DNA. This sliding property has been...

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Bibliographic Details
Main Authors: Jean-Charles Walter, Jérôme Rech, Nils-Ole Walliser, Jérôme Dorignac, Frédéric Geniet, John Palmeri, Andrea Parmeggiani, Jean-Yves Bouet
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:iScience
Subjects:
Gene Process
Microbial Genetics
Systems Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220310580

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