Modulating Growth Factor Receptor Signaling to Promote Corneal Epithelial Homeostasis
The corneal epithelium is the first anatomical barrier between the environment and the cornea; it is critical for proper light refraction onto the retina and prevents pathogens (e.g., bacteria, viruses) from entering the immune-privileged eye. Trauma to the highly innervated corneal epithelium is ex...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/12/23/2730 |
| _version_ | 1797400318718246912 |
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| author | Kate E. Tarvestad-Laise Brian P. Ceresa |
| author_facet | Kate E. Tarvestad-Laise Brian P. Ceresa |
| author_sort | Kate E. Tarvestad-Laise |
| collection | DOAJ |
| description | The corneal epithelium is the first anatomical barrier between the environment and the cornea; it is critical for proper light refraction onto the retina and prevents pathogens (e.g., bacteria, viruses) from entering the immune-privileged eye. Trauma to the highly innervated corneal epithelium is extremely painful and if not resolved quickly or properly, can lead to infection and ultimately blindness. The healthy eye produces its own growth factors and is continuously bathed in tear fluid that contains these proteins and other nutrients to maintain the rapid turnover and homeostasis of the ocular surface. In this article, we review the roles of growth factors in corneal epithelial homeostasis and regeneration and some of the limitations to their use therapeutically. |
| first_indexed | 2024-03-09T01:53:48Z |
| format | Article |
| id | doaj.art-60f8d91298054e2e8105bbcdbe9ca783 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T01:53:48Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-60f8d91298054e2e8105bbcdbe9ca7832023-12-08T15:13:11ZengMDPI AGCells2073-44092023-11-011223273010.3390/cells12232730Modulating Growth Factor Receptor Signaling to Promote Corneal Epithelial HomeostasisKate E. Tarvestad-Laise0Brian P. Ceresa1Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, USADepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, USAThe corneal epithelium is the first anatomical barrier between the environment and the cornea; it is critical for proper light refraction onto the retina and prevents pathogens (e.g., bacteria, viruses) from entering the immune-privileged eye. Trauma to the highly innervated corneal epithelium is extremely painful and if not resolved quickly or properly, can lead to infection and ultimately blindness. The healthy eye produces its own growth factors and is continuously bathed in tear fluid that contains these proteins and other nutrients to maintain the rapid turnover and homeostasis of the ocular surface. In this article, we review the roles of growth factors in corneal epithelial homeostasis and regeneration and some of the limitations to their use therapeutically.https://www.mdpi.com/2073-4409/12/23/2730corneacorneal epitheliumgrowth factorgrowth factor receptorc-Metwound healing |
| spellingShingle | Kate E. Tarvestad-Laise Brian P. Ceresa Modulating Growth Factor Receptor Signaling to Promote Corneal Epithelial Homeostasis Cells cornea corneal epithelium growth factor growth factor receptor c-Met wound healing |
| title | Modulating Growth Factor Receptor Signaling to Promote Corneal Epithelial Homeostasis |
| title_full | Modulating Growth Factor Receptor Signaling to Promote Corneal Epithelial Homeostasis |
| title_fullStr | Modulating Growth Factor Receptor Signaling to Promote Corneal Epithelial Homeostasis |
| title_full_unstemmed | Modulating Growth Factor Receptor Signaling to Promote Corneal Epithelial Homeostasis |
| title_short | Modulating Growth Factor Receptor Signaling to Promote Corneal Epithelial Homeostasis |
| title_sort | modulating growth factor receptor signaling to promote corneal epithelial homeostasis |
| topic | cornea corneal epithelium growth factor growth factor receptor c-Met wound healing |
| url | https://www.mdpi.com/2073-4409/12/23/2730 |
| work_keys_str_mv | AT kateetarvestadlaise modulatinggrowthfactorreceptorsignalingtopromotecornealepithelialhomeostasis AT brianpceresa modulatinggrowthfactorreceptorsignalingtopromotecornealepithelialhomeostasis |