Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by <i>Schistosoma japonicum</i> Infection

Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by <i>Schistosoma japonicum</i> Infection

Background: Schistosomiasis is an immunopathogenic disease in which Th17 cells play vital roles. Hepatic granuloma formation and subsequent fibrosis are its main pathologic manifestations and the leading causes of hepatic cirrhosis, and effective therapeutic interventions are lacking. In this study,...

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Bibliographic Details
Main Authors: Wei Zhou, Yingying Yang, Congjin Mei, Panpan Dong, Shasha Mu, Hongchu Wu, Yonghua Zhou, Yi Zheng, Fukun Guo, Jun-Qi Yang
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
rhoa-rock
fasudil
th17
<i>schistosoma japonicum</i>
hepatic fibrosis
Online Access:https://www.mdpi.com/2073-4409/8/10/1262

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