Evaluation of Ultrasound-Based Point Shear Wave Elastography for Differential Diagnosis of Pancreatic Diseases
Introduction: A variety of imaging techniques exists for the diagnosis of pancreatic disorders. None of the broadly applied diagnostic methods utilizes elasticity as an indicator of tissue damage. A well-known fact is that both chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDA) are...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-03-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/12/4/841 |
| _version_ | 1827621045233778688 |
|---|---|
| author | Bozhidar Hristov Vladimir Andonov Daniel Doykov Silvia Tsvetkova Katya Doykova Mladen Doykov |
| author_facet | Bozhidar Hristov Vladimir Andonov Daniel Doykov Silvia Tsvetkova Katya Doykova Mladen Doykov |
| author_sort | Bozhidar Hristov |
| collection | DOAJ |
| description | Introduction: A variety of imaging techniques exists for the diagnosis of pancreatic disorders. None of the broadly applied diagnostic methods utilizes elasticity as an indicator of tissue damage. A well-known fact is that both chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDA) are associated with the development of prominent fibrosis (increased tissue stiffness). Purpose: To prospectively assess the accuracy of point shear wave elastography (pSWE) in differentiating between benign and malignant pancreatic diseases, establish a cut-off value for the diagnosis of PDA, and evaluate the influence of certain variables on the obtained results. Materials and methods: The present study included 78 patients who were admitted at the Department of Gastroenterology at the university hospital “Kaspela” between December 2017 and August 2021 for diagnosis and/or treatment of pancreatic disorders. Based on the clinical criteria, diagnostic imaging, and histological findings, patients were divided into the CP and PDA group. The ultrasound based pSWE technique was applied and shear wave velocity (SWV) was measured. The depth of region of interest (ROI) and successful measurement rate were also recorded. Results: The mean ± SD SWV values established through pSWE were 1.75 ± 0.34 m/s and 2.93 ± 0.91 m/s for the CP and PDA, respectively. With a cut-off value of 2.09 m/s, we calculated the sensitivity (Se), specificity (Sp), and accuracy for differentiating between CP and PDA of 89.47%, 91.20%, and 88.60%, respectively. Of the examined variables, BMI and depth of ROI in the CP group and sex in the PDA group showed a statistically significant influence on the obtained results. Conclusions: pSWE may be utilized as a differential diagnostic modality in patients with suspected CP or PDA. |
| first_indexed | 2024-03-09T10:57:15Z |
| format | Article |
| id | doaj.art-60fc19b2d8ea49a9a12eb0b677696941 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T10:57:15Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-60fc19b2d8ea49a9a12eb0b6776969412023-12-01T01:31:23ZengMDPI AGDiagnostics2075-44182022-03-0112484110.3390/diagnostics12040841Evaluation of Ultrasound-Based Point Shear Wave Elastography for Differential Diagnosis of Pancreatic DiseasesBozhidar Hristov0Vladimir Andonov1Daniel Doykov2Silvia Tsvetkova3Katya Doykova4Mladen Doykov5Second Department of Internal Diseases, Section “Gastroenterology”, Medical Faculty, Medical University of Plovdiv, 6000 Plovdiv, BulgariaSecond Department of Internal Diseases, Section “Gastroenterology”, Medical Faculty, Medical University of Plovdiv, 6000 Plovdiv, BulgariaSecond Department of Internal Diseases, Section “Gastroenterology”, Medical Faculty, Medical University of Plovdiv, 6000 Plovdiv, BulgariaDepartment of Diagnostic Imaging, Medical Faculty, Medical University of Plovdiv, 6000 Plovdiv, BulgariaDepartment of Diagnostic Imaging, Medical Faculty, Medical University of Plovdiv, 6000 Plovdiv, BulgariaDepartment of Urology and General Medicine, Medical Faculty, Medical University of Plovdiv, 6000 Plovdiv, BulgariaIntroduction: A variety of imaging techniques exists for the diagnosis of pancreatic disorders. None of the broadly applied diagnostic methods utilizes elasticity as an indicator of tissue damage. A well-known fact is that both chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDA) are associated with the development of prominent fibrosis (increased tissue stiffness). Purpose: To prospectively assess the accuracy of point shear wave elastography (pSWE) in differentiating between benign and malignant pancreatic diseases, establish a cut-off value for the diagnosis of PDA, and evaluate the influence of certain variables on the obtained results. Materials and methods: The present study included 78 patients who were admitted at the Department of Gastroenterology at the university hospital “Kaspela” between December 2017 and August 2021 for diagnosis and/or treatment of pancreatic disorders. Based on the clinical criteria, diagnostic imaging, and histological findings, patients were divided into the CP and PDA group. The ultrasound based pSWE technique was applied and shear wave velocity (SWV) was measured. The depth of region of interest (ROI) and successful measurement rate were also recorded. Results: The mean ± SD SWV values established through pSWE were 1.75 ± 0.34 m/s and 2.93 ± 0.91 m/s for the CP and PDA, respectively. With a cut-off value of 2.09 m/s, we calculated the sensitivity (Se), specificity (Sp), and accuracy for differentiating between CP and PDA of 89.47%, 91.20%, and 88.60%, respectively. Of the examined variables, BMI and depth of ROI in the CP group and sex in the PDA group showed a statistically significant influence on the obtained results. Conclusions: pSWE may be utilized as a differential diagnostic modality in patients with suspected CP or PDA.https://www.mdpi.com/2075-4418/12/4/841pancreatitispancreatic carcinomaelastographypSWE |
| spellingShingle | Bozhidar Hristov Vladimir Andonov Daniel Doykov Silvia Tsvetkova Katya Doykova Mladen Doykov Evaluation of Ultrasound-Based Point Shear Wave Elastography for Differential Diagnosis of Pancreatic Diseases Diagnostics pancreatitis pancreatic carcinoma elastography pSWE |
| title | Evaluation of Ultrasound-Based Point Shear Wave Elastography for Differential Diagnosis of Pancreatic Diseases |
| title_full | Evaluation of Ultrasound-Based Point Shear Wave Elastography for Differential Diagnosis of Pancreatic Diseases |
| title_fullStr | Evaluation of Ultrasound-Based Point Shear Wave Elastography for Differential Diagnosis of Pancreatic Diseases |
| title_full_unstemmed | Evaluation of Ultrasound-Based Point Shear Wave Elastography for Differential Diagnosis of Pancreatic Diseases |
| title_short | Evaluation of Ultrasound-Based Point Shear Wave Elastography for Differential Diagnosis of Pancreatic Diseases |
| title_sort | evaluation of ultrasound based point shear wave elastography for differential diagnosis of pancreatic diseases |
| topic | pancreatitis pancreatic carcinoma elastography pSWE |
| url | https://www.mdpi.com/2075-4418/12/4/841 |
| work_keys_str_mv | AT bozhidarhristov evaluationofultrasoundbasedpointshearwaveelastographyfordifferentialdiagnosisofpancreaticdiseases AT vladimirandonov evaluationofultrasoundbasedpointshearwaveelastographyfordifferentialdiagnosisofpancreaticdiseases AT danieldoykov evaluationofultrasoundbasedpointshearwaveelastographyfordifferentialdiagnosisofpancreaticdiseases AT silviatsvetkova evaluationofultrasoundbasedpointshearwaveelastographyfordifferentialdiagnosisofpancreaticdiseases AT katyadoykova evaluationofultrasoundbasedpointshearwaveelastographyfordifferentialdiagnosisofpancreaticdiseases AT mladendoykov evaluationofultrasoundbasedpointshearwaveelastographyfordifferentialdiagnosisofpancreaticdiseases |