Dietary sodium butyrate and forskolin promote cell proliferation to resist Citrobacter rodentium infection by lysozyme upregulation
The invasion of pathogens derived from diet or the environment triggers intestinal inflammation, which is a result of the host intestinal barrier damage and immune dysfunction, such as the decrease of host defense peptides (HDPs) and inhibition of cell proliferation. Herein, the siRNA interference d...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623005935 |
| _version_ | 1797356123930492928 |
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| author | Jinping Wang Jianmin Wu Zishen Lin Ning Ma Zhaoyue Men Chao Zhang Xi Ma Hongyu Zheng |
| author_facet | Jinping Wang Jianmin Wu Zishen Lin Ning Ma Zhaoyue Men Chao Zhang Xi Ma Hongyu Zheng |
| author_sort | Jinping Wang |
| collection | DOAJ |
| description | The invasion of pathogens derived from diet or the environment triggers intestinal inflammation, which is a result of the host intestinal barrier damage and immune dysfunction, such as the decrease of host defense peptides (HDPs) and inhibition of cell proliferation. Herein, the siRNA interference demonstrated that a critical lysozyme, which was mainly induced by dietary supplementations of sodium butyrate and forskolin, improved cell proliferation by inhibiting p38 MAPK and JNK signaling pathways and reinforced the intestinal barrier. Moreover, we established a mouse model of intestinal inflammation with Citrobacter rodentium (C. rodentium). It was found that NaBu and FSK stimulated intestinal epithelial proliferation to repair barrier damage, and performed stronger disease resistance to C. rodentium infection on account of the lysozyme upregulation in colon. Therefore, this study revealed that NaBu and FSK prevented or alleviated the development of foodborne infections by promoting lysozyme expression, which may be mediated by the effect of lysozyme on promoting cell proliferation and improving barrier function. |
| first_indexed | 2024-03-08T14:21:06Z |
| format | Article |
| id | doaj.art-60fc77a382c14a0eacadf932298319fe |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-08T14:21:06Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-60fc77a382c14a0eacadf932298319fe2024-01-14T05:37:30ZengElsevierJournal of Functional Foods1756-46462024-01-01112105993Dietary sodium butyrate and forskolin promote cell proliferation to resist Citrobacter rodentium infection by lysozyme upregulationJinping Wang0Jianmin Wu1Zishen Lin2Ning Ma3Zhaoyue Men4Chao Zhang5Xi Ma6Hongyu Zheng7Trauma Center, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China; State Key Laboratory of Animal Nutrition and Feeding, Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition and Feeding, Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China; Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition and Feeding, Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition and Feeding, Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition and Feeding, Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaKey Laboratory of Innovative Utilization of Local Cattle and Sheep Germplasm Resources (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Zhengzhou University, Zhengzhou 450001, ChinaState Key Laboratory of Animal Nutrition and Feeding, Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China; Corresponding authors.Trauma Center, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China; Corresponding authors.The invasion of pathogens derived from diet or the environment triggers intestinal inflammation, which is a result of the host intestinal barrier damage and immune dysfunction, such as the decrease of host defense peptides (HDPs) and inhibition of cell proliferation. Herein, the siRNA interference demonstrated that a critical lysozyme, which was mainly induced by dietary supplementations of sodium butyrate and forskolin, improved cell proliferation by inhibiting p38 MAPK and JNK signaling pathways and reinforced the intestinal barrier. Moreover, we established a mouse model of intestinal inflammation with Citrobacter rodentium (C. rodentium). It was found that NaBu and FSK stimulated intestinal epithelial proliferation to repair barrier damage, and performed stronger disease resistance to C. rodentium infection on account of the lysozyme upregulation in colon. Therefore, this study revealed that NaBu and FSK prevented or alleviated the development of foodborne infections by promoting lysozyme expression, which may be mediated by the effect of lysozyme on promoting cell proliferation and improving barrier function.http://www.sciencedirect.com/science/article/pii/S1756464623005935Sodium butyrateForskolinProliferationInflammationHost defense peptideCitrobacter rodentium |
| spellingShingle | Jinping Wang Jianmin Wu Zishen Lin Ning Ma Zhaoyue Men Chao Zhang Xi Ma Hongyu Zheng Dietary sodium butyrate and forskolin promote cell proliferation to resist Citrobacter rodentium infection by lysozyme upregulation Journal of Functional Foods Sodium butyrate Forskolin Proliferation Inflammation Host defense peptide Citrobacter rodentium |
| title | Dietary sodium butyrate and forskolin promote cell proliferation to resist Citrobacter rodentium infection by lysozyme upregulation |
| title_full | Dietary sodium butyrate and forskolin promote cell proliferation to resist Citrobacter rodentium infection by lysozyme upregulation |
| title_fullStr | Dietary sodium butyrate and forskolin promote cell proliferation to resist Citrobacter rodentium infection by lysozyme upregulation |
| title_full_unstemmed | Dietary sodium butyrate and forskolin promote cell proliferation to resist Citrobacter rodentium infection by lysozyme upregulation |
| title_short | Dietary sodium butyrate and forskolin promote cell proliferation to resist Citrobacter rodentium infection by lysozyme upregulation |
| title_sort | dietary sodium butyrate and forskolin promote cell proliferation to resist citrobacter rodentium infection by lysozyme upregulation |
| topic | Sodium butyrate Forskolin Proliferation Inflammation Host defense peptide Citrobacter rodentium |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623005935 |
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