The Alcohol–High-Density Lipoprotein Athero-Protective Axis
Ingestion of alcohol is associated with numerous changes in human energy metabolism, especially that of plasma lipids and lipoproteins. Regular moderate alcohol consumption is associated with reduced atherosclerotic cardiovascular disease (ASCVD), an effect that has been attributed to the concurrent...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/10/7/987 |
| _version_ | 1827713832829583360 |
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| author | Corina Rosales Baiba K. Gillard Antonio M. Gotto Henry J. Pownall |
| author_facet | Corina Rosales Baiba K. Gillard Antonio M. Gotto Henry J. Pownall |
| author_sort | Corina Rosales |
| collection | DOAJ |
| description | Ingestion of alcohol is associated with numerous changes in human energy metabolism, especially that of plasma lipids and lipoproteins. Regular moderate alcohol consumption is associated with reduced atherosclerotic cardiovascular disease (ASCVD), an effect that has been attributed to the concurrent elevations of plasma high-density lipoprotein-cholesterol (HDL-C) concentrations. More recent evidence has accrued against the hypothesis that raising plasma HDL concentrations prevents ASCVD so that other metabolic processes associated with alcohol consumption have been considered. This review explored the roles of other metabolites induced by alcohol consumption—triglyceride-rich lipoproteins, non-esterified free fatty acids, and acetate, the terminal alcohol metabolite in athero-protection: Current evidence suggests that acetate has a key role in athero-protection but additional studies are needed. |
| first_indexed | 2024-03-10T18:44:29Z |
| format | Article |
| id | doaj.art-60fd06d754a146f2893fa8f702286168 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T18:44:29Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-60fd06d754a146f2893fa8f7022861682023-11-20T05:35:04ZengMDPI AGBiomolecules2218-273X2020-07-0110798710.3390/biom10070987The Alcohol–High-Density Lipoprotein Athero-Protective AxisCorina Rosales0Baiba K. Gillard1Antonio M. Gotto2Henry J. Pownall3Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USAHouston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USAHouston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USAHouston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USAIngestion of alcohol is associated with numerous changes in human energy metabolism, especially that of plasma lipids and lipoproteins. Regular moderate alcohol consumption is associated with reduced atherosclerotic cardiovascular disease (ASCVD), an effect that has been attributed to the concurrent elevations of plasma high-density lipoprotein-cholesterol (HDL-C) concentrations. More recent evidence has accrued against the hypothesis that raising plasma HDL concentrations prevents ASCVD so that other metabolic processes associated with alcohol consumption have been considered. This review explored the roles of other metabolites induced by alcohol consumption—triglyceride-rich lipoproteins, non-esterified free fatty acids, and acetate, the terminal alcohol metabolite in athero-protection: Current evidence suggests that acetate has a key role in athero-protection but additional studies are needed.https://www.mdpi.com/2218-273X/10/7/987alcoholtriglycerideshigh-density lipoproteinscholesterolcardiovascular disease |
| spellingShingle | Corina Rosales Baiba K. Gillard Antonio M. Gotto Henry J. Pownall The Alcohol–High-Density Lipoprotein Athero-Protective Axis Biomolecules alcohol triglycerides high-density lipoproteins cholesterol cardiovascular disease |
| title | The Alcohol–High-Density Lipoprotein Athero-Protective Axis |
| title_full | The Alcohol–High-Density Lipoprotein Athero-Protective Axis |
| title_fullStr | The Alcohol–High-Density Lipoprotein Athero-Protective Axis |
| title_full_unstemmed | The Alcohol–High-Density Lipoprotein Athero-Protective Axis |
| title_short | The Alcohol–High-Density Lipoprotein Athero-Protective Axis |
| title_sort | alcohol high density lipoprotein athero protective axis |
| topic | alcohol triglycerides high-density lipoproteins cholesterol cardiovascular disease |
| url | https://www.mdpi.com/2218-273X/10/7/987 |
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