Mitochondria and Antibiotics: For Good or for Evil?
The discovery and application of antibiotics in the common clinical practice has undeniably been one of the major medical advances in our times. Their use meant a drastic drop in infectious diseases-related mortality and contributed to prolonging human life expectancy worldwide. Nevertheless, antibi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/7/1050 |
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| author | Juan M. Suárez-Rivero Carmen J. Pastor-Maldonado Suleva Povea-Cabello Mónica Álvarez-Córdoba Irene Villalón-García Marta Talaverón-Rey Alejandra Suárez-Carrillo Manuel Munuera-Cabeza José A. Sánchez-Alcázar |
| author_facet | Juan M. Suárez-Rivero Carmen J. Pastor-Maldonado Suleva Povea-Cabello Mónica Álvarez-Córdoba Irene Villalón-García Marta Talaverón-Rey Alejandra Suárez-Carrillo Manuel Munuera-Cabeza José A. Sánchez-Alcázar |
| author_sort | Juan M. Suárez-Rivero |
| collection | DOAJ |
| description | The discovery and application of antibiotics in the common clinical practice has undeniably been one of the major medical advances in our times. Their use meant a drastic drop in infectious diseases-related mortality and contributed to prolonging human life expectancy worldwide. Nevertheless, antibiotics are considered by many a double-edged sword. Their extensive use in the past few years has given rise to a global problem: antibiotic resistance. This factor and the increasing evidence that a wide range of antibiotics can damage mammalian mitochondria, have driven a significant sector of the medical and scientific communities to advise against the use of antibiotics for purposes other to treating severe infections. Notwithstanding, a notorious number of recent studies support the use of these drugs to treat very diverse conditions, ranging from cancer to neurodegenerative or mitochondrial diseases. In this context, there is great controversy on whether the risks associated to antibiotics outweigh their promising beneficial features. The aim of this review is to provide insight in the topic, purpose for which the most relevant findings regarding antibiotic therapies have been discussed. |
| first_indexed | 2024-03-10T09:44:59Z |
| format | Article |
| id | doaj.art-60ff57fcb9374eab9e2da591525634a9 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T09:44:59Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-60ff57fcb9374eab9e2da591525634a92023-11-22T03:19:27ZengMDPI AGBiomolecules2218-273X2021-07-01117105010.3390/biom11071050Mitochondria and Antibiotics: For Good or for Evil?Juan M. Suárez-Rivero0Carmen J. Pastor-Maldonado1Suleva Povea-Cabello2Mónica Álvarez-Córdoba3Irene Villalón-García4Marta Talaverón-Rey5Alejandra Suárez-Carrillo6Manuel Munuera-Cabeza7José A. Sánchez-Alcázar8Andalusian Center for Developmental Biology (CABD-CSIC-Pablo de Olavide University) and Center for Biomedical Network Research on Rare Diseases, Carlos III Health Institute, 41013 Seville, SpainAndalusian Center for Developmental Biology (CABD-CSIC-Pablo de Olavide University) and Center for Biomedical Network Research on Rare Diseases, Carlos III Health Institute, 41013 Seville, SpainAndalusian Center for Developmental Biology (CABD-CSIC-Pablo de Olavide University) and Center for Biomedical Network Research on Rare Diseases, Carlos III Health Institute, 41013 Seville, SpainAndalusian Center for Developmental Biology (CABD-CSIC-Pablo de Olavide University) and Center for Biomedical Network Research on Rare Diseases, Carlos III Health Institute, 41013 Seville, SpainAndalusian Center for Developmental Biology (CABD-CSIC-Pablo de Olavide University) and Center for Biomedical Network Research on Rare Diseases, Carlos III Health Institute, 41013 Seville, SpainAndalusian Center for Developmental Biology (CABD-CSIC-Pablo de Olavide University) and Center for Biomedical Network Research on Rare Diseases, Carlos III Health Institute, 41013 Seville, SpainAndalusian Center for Developmental Biology (CABD-CSIC-Pablo de Olavide University) and Center for Biomedical Network Research on Rare Diseases, Carlos III Health Institute, 41013 Seville, SpainAndalusian Center for Developmental Biology (CABD-CSIC-Pablo de Olavide University) and Center for Biomedical Network Research on Rare Diseases, Carlos III Health Institute, 41013 Seville, SpainAndalusian Center for Developmental Biology (CABD-CSIC-Pablo de Olavide University) and Center for Biomedical Network Research on Rare Diseases, Carlos III Health Institute, 41013 Seville, SpainThe discovery and application of antibiotics in the common clinical practice has undeniably been one of the major medical advances in our times. Their use meant a drastic drop in infectious diseases-related mortality and contributed to prolonging human life expectancy worldwide. Nevertheless, antibiotics are considered by many a double-edged sword. Their extensive use in the past few years has given rise to a global problem: antibiotic resistance. This factor and the increasing evidence that a wide range of antibiotics can damage mammalian mitochondria, have driven a significant sector of the medical and scientific communities to advise against the use of antibiotics for purposes other to treating severe infections. Notwithstanding, a notorious number of recent studies support the use of these drugs to treat very diverse conditions, ranging from cancer to neurodegenerative or mitochondrial diseases. In this context, there is great controversy on whether the risks associated to antibiotics outweigh their promising beneficial features. The aim of this review is to provide insight in the topic, purpose for which the most relevant findings regarding antibiotic therapies have been discussed.https://www.mdpi.com/2218-273X/11/7/1050mitochondriaantibioticsunfolded protein responseneurodegenerationcancermitochondrial diseases |
| spellingShingle | Juan M. Suárez-Rivero Carmen J. Pastor-Maldonado Suleva Povea-Cabello Mónica Álvarez-Córdoba Irene Villalón-García Marta Talaverón-Rey Alejandra Suárez-Carrillo Manuel Munuera-Cabeza José A. Sánchez-Alcázar Mitochondria and Antibiotics: For Good or for Evil? Biomolecules mitochondria antibiotics unfolded protein response neurodegeneration cancer mitochondrial diseases |
| title | Mitochondria and Antibiotics: For Good or for Evil? |
| title_full | Mitochondria and Antibiotics: For Good or for Evil? |
| title_fullStr | Mitochondria and Antibiotics: For Good or for Evil? |
| title_full_unstemmed | Mitochondria and Antibiotics: For Good or for Evil? |
| title_short | Mitochondria and Antibiotics: For Good or for Evil? |
| title_sort | mitochondria and antibiotics for good or for evil |
| topic | mitochondria antibiotics unfolded protein response neurodegeneration cancer mitochondrial diseases |
| url | https://www.mdpi.com/2218-273X/11/7/1050 |
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