Methyl-4-hydroxy-2-(2-hydroxypropan-2-yl)-6-methyl-2,3-dihydrobenzofuran-5-carboxylate
Microorganisms are an important source of compounds that are pharmaceutically active, both as leads and as scaffolds for synthesis. Often, interesting chemistry is uncovered by exploring new biomes, of which the Chilean Atacama Desert is a prime example. This paper describes the isolation and struct...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
|
| Series: | Molbank |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-8599/2023/3/M1697 |
| _version_ | 1797578671535423488 |
|---|---|
| author | Rishi Vachaspathy Astakala Gagan Preet Rainer Ebel Marcel Jaspars |
| author_facet | Rishi Vachaspathy Astakala Gagan Preet Rainer Ebel Marcel Jaspars |
| author_sort | Rishi Vachaspathy Astakala |
| collection | DOAJ |
| description | Microorganisms are an important source of compounds that are pharmaceutically active, both as leads and as scaffolds for synthesis. Often, interesting chemistry is uncovered by exploring new biomes, of which the Chilean Atacama Desert is a prime example. This paper describes the isolation and structural characterisation, using HR-LCMS and 1D and 2D NMR, of a new compound belonging to a family of compounds called radstrictins. The compound was isolated from a fungus, that had itself been isolated from a soil sample from the Atacama Desert. The compound was tested against pathogenic strains associated with bovine mastitis, but was found to be devoid of antimicrobial activity. |
| first_indexed | 2024-03-10T22:26:04Z |
| format | Article |
| id | doaj.art-61017d97ce0c488fb2dec4b8df03d5f1 |
| institution | Directory Open Access Journal |
| issn | 1422-8599 |
| language | English |
| last_indexed | 2024-03-10T22:26:04Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj.art-61017d97ce0c488fb2dec4b8df03d5f12023-11-19T12:06:47ZengMDPI AGMolbank1422-85992023-07-0120233M169710.3390/M1697Methyl-4-hydroxy-2-(2-hydroxypropan-2-yl)-6-methyl-2,3-dihydrobenzofuran-5-carboxylateRishi Vachaspathy Astakala0Gagan Preet1Rainer Ebel2Marcel Jaspars3Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen AB24 3UE, UKMarine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen AB24 3UE, UKMarine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen AB24 3UE, UKMarine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen AB24 3UE, UKMicroorganisms are an important source of compounds that are pharmaceutically active, both as leads and as scaffolds for synthesis. Often, interesting chemistry is uncovered by exploring new biomes, of which the Chilean Atacama Desert is a prime example. This paper describes the isolation and structural characterisation, using HR-LCMS and 1D and 2D NMR, of a new compound belonging to a family of compounds called radstrictins. The compound was isolated from a fungus, that had itself been isolated from a soil sample from the Atacama Desert. The compound was tested against pathogenic strains associated with bovine mastitis, but was found to be devoid of antimicrobial activity.https://www.mdpi.com/1422-8599/2023/3/M1697radstrictinsnatural productsAtacama Desertfungihigh-resolution MS2D NMR |
| spellingShingle | Rishi Vachaspathy Astakala Gagan Preet Rainer Ebel Marcel Jaspars Methyl-4-hydroxy-2-(2-hydroxypropan-2-yl)-6-methyl-2,3-dihydrobenzofuran-5-carboxylate Molbank radstrictins natural products Atacama Desert fungi high-resolution MS 2D NMR |
| title | Methyl-4-hydroxy-2-(2-hydroxypropan-2-yl)-6-methyl-2,3-dihydrobenzofuran-5-carboxylate |
| title_full | Methyl-4-hydroxy-2-(2-hydroxypropan-2-yl)-6-methyl-2,3-dihydrobenzofuran-5-carboxylate |
| title_fullStr | Methyl-4-hydroxy-2-(2-hydroxypropan-2-yl)-6-methyl-2,3-dihydrobenzofuran-5-carboxylate |
| title_full_unstemmed | Methyl-4-hydroxy-2-(2-hydroxypropan-2-yl)-6-methyl-2,3-dihydrobenzofuran-5-carboxylate |
| title_short | Methyl-4-hydroxy-2-(2-hydroxypropan-2-yl)-6-methyl-2,3-dihydrobenzofuran-5-carboxylate |
| title_sort | methyl 4 hydroxy 2 2 hydroxypropan 2 yl 6 methyl 2 3 dihydrobenzofuran 5 carboxylate |
| topic | radstrictins natural products Atacama Desert fungi high-resolution MS 2D NMR |
| url | https://www.mdpi.com/1422-8599/2023/3/M1697 |
| work_keys_str_mv | AT rishivachaspathyastakala methyl4hydroxy22hydroxypropan2yl6methyl23dihydrobenzofuran5carboxylate AT gaganpreet methyl4hydroxy22hydroxypropan2yl6methyl23dihydrobenzofuran5carboxylate AT rainerebel methyl4hydroxy22hydroxypropan2yl6methyl23dihydrobenzofuran5carboxylate AT marceljaspars methyl4hydroxy22hydroxypropan2yl6methyl23dihydrobenzofuran5carboxylate |