Overall survival and tumor recurrence after surgical resection for primary malignant chest wall tumors: a single-center, single-surgeon experience
Background and objectives: Malignant primary chest wall tumors (PCWTs) comprise a rare group of thoracic tumors with unique anatomical considerations, and experience with wide surgical resection is limited to specialty referral centers and specific diagnoses. We investigated the tumor recurrence and...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-04-01
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| Series: | Journal of Orthopaedic Surgery |
| Online Access: | https://doi.org/10.1177/2309499019838296 |
| _version_ | 1818446062772289536 |
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| author | Aalap C Shah Kazimierz W Komperda Arun A Mavanur Steven W Thorpe Kurt R Weiss Mark A Goodman |
| author_facet | Aalap C Shah Kazimierz W Komperda Arun A Mavanur Steven W Thorpe Kurt R Weiss Mark A Goodman |
| author_sort | Aalap C Shah |
| collection | DOAJ |
| description | Background and objectives: Malignant primary chest wall tumors (PCWTs) comprise a rare group of thoracic tumors with unique anatomical considerations, and experience with wide surgical resection is limited to specialty referral centers and specific diagnoses. We investigated the tumor recurrence and overall survival (OS) for patients with a variety of PCWTs diagnoses at our institution. Methods: From 1991 to 2010, patients with malignant PCWT undergoing wide surgical resection for curative intent under a single surgeon were reviewed. Diagnosis and grade (if applicable) of surgical pathology, along with patient demographics, neoadjuvant chemotherapy or radiation therapy, and outcomes (complications, recurrence, and OS) at follow-up were analyzed. Results: One hundred fifteen patients were included in the study. The most common tumor diagnoses included pleomorphic sarcoma and liposarcoma. Negative margins were achieved in 70 (74%) of cases. Postoperative complications were reported in 21 (20%) cases. The 5-year survival rate was 54%, while the 10-year survival rate was 29%. The local and distant recurrence rates were 50% and 38%, respectively. OS was significantly less in patients with any recurrence ( p < 0.001) but not significantly different between pathology grades ( p = 0.28). Conclusions: Wide resection for malignant PCWT is feasible when undertaken for a heterogenous group of diagnoses. |
| first_indexed | 2024-12-14T19:41:45Z |
| format | Article |
| id | doaj.art-610204d32e9145dcb22ffde378ec1cee |
| institution | Directory Open Access Journal |
| issn | 2309-4990 |
| language | English |
| last_indexed | 2024-12-14T19:41:45Z |
| publishDate | 2019-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Orthopaedic Surgery |
| spelling | doaj.art-610204d32e9145dcb22ffde378ec1cee2022-12-21T22:49:42ZengSAGE PublishingJournal of Orthopaedic Surgery2309-49902019-04-012710.1177/2309499019838296Overall survival and tumor recurrence after surgical resection for primary malignant chest wall tumors: a single-center, single-surgeon experienceAalap C Shah0Kazimierz W Komperda1Arun A Mavanur2Steven W Thorpe3Kurt R Weiss4Mark A Goodman5 Department of Anesthesiology, Perioperative and Pain Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA Department of Orthopedic Surgery, Mount Sinai Medical Center, New York, NY, USA Department of Surgical Oncology, Sinai Hospital of Baltimore, Baltimore, MD, USA Department of Orthopaedic Surgery and Musculoskeletal Oncology, University of California, Davis, Medical Center, Sacramento, CA, USA Department of Orthopedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA Department of Orthopedic Surgery and Musculoskeletal Oncology, University of Pittsburgh Medical Center and Hillman Cancer Institute, Pittsburgh, PA, USABackground and objectives: Malignant primary chest wall tumors (PCWTs) comprise a rare group of thoracic tumors with unique anatomical considerations, and experience with wide surgical resection is limited to specialty referral centers and specific diagnoses. We investigated the tumor recurrence and overall survival (OS) for patients with a variety of PCWTs diagnoses at our institution. Methods: From 1991 to 2010, patients with malignant PCWT undergoing wide surgical resection for curative intent under a single surgeon were reviewed. Diagnosis and grade (if applicable) of surgical pathology, along with patient demographics, neoadjuvant chemotherapy or radiation therapy, and outcomes (complications, recurrence, and OS) at follow-up were analyzed. Results: One hundred fifteen patients were included in the study. The most common tumor diagnoses included pleomorphic sarcoma and liposarcoma. Negative margins were achieved in 70 (74%) of cases. Postoperative complications were reported in 21 (20%) cases. The 5-year survival rate was 54%, while the 10-year survival rate was 29%. The local and distant recurrence rates were 50% and 38%, respectively. OS was significantly less in patients with any recurrence ( p < 0.001) but not significantly different between pathology grades ( p = 0.28). Conclusions: Wide resection for malignant PCWT is feasible when undertaken for a heterogenous group of diagnoses.https://doi.org/10.1177/2309499019838296 |
| spellingShingle | Aalap C Shah Kazimierz W Komperda Arun A Mavanur Steven W Thorpe Kurt R Weiss Mark A Goodman Overall survival and tumor recurrence after surgical resection for primary malignant chest wall tumors: a single-center, single-surgeon experience Journal of Orthopaedic Surgery |
| title | Overall survival and tumor recurrence after surgical resection for primary malignant chest wall tumors: a single-center, single-surgeon experience |
| title_full | Overall survival and tumor recurrence after surgical resection for primary malignant chest wall tumors: a single-center, single-surgeon experience |
| title_fullStr | Overall survival and tumor recurrence after surgical resection for primary malignant chest wall tumors: a single-center, single-surgeon experience |
| title_full_unstemmed | Overall survival and tumor recurrence after surgical resection for primary malignant chest wall tumors: a single-center, single-surgeon experience |
| title_short | Overall survival and tumor recurrence after surgical resection for primary malignant chest wall tumors: a single-center, single-surgeon experience |
| title_sort | overall survival and tumor recurrence after surgical resection for primary malignant chest wall tumors a single center single surgeon experience |
| url | https://doi.org/10.1177/2309499019838296 |
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