Molecular Signature of Extracellular Vesicular Small Non-Coding RNAs Derived from Cerebrospinal Fluid of Leptomeningeal Metastasis Patients: Functional Implication of miR-21 and Other Small RNAs in Cancer Malignancy

Molecular Signature of Extracellular Vesicular Small Non-Coding RNAs Derived from Cerebrospinal Fluid of Leptomeningeal Metastasis Patients: Functional Implication of miR-21 and Other Small RNAs in Cancer Malignancy

Leptomeningeal metastasis (LM) is a fatal and rare complication of cancer in which the cancer spreads via the cerebrospinal fluid (CSF). At present, there is no definitive treatment or diagnosis for this deleterious disease. In this study, we systemically and quantitatively investigated biased expre...

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Bibliographic Details
Main Authors: Kyue-Yim Lee, Yoona Seo, Ji Hye Im, Jiho Rhim, Woosun Baek, Sewon Kim, Ji-Woong Kwon, Byong Chul Yoo, Sang Hoon Shin, Heon Yoo, Jong Bae Park, Ho-Shin Gwak, Jong Heon Kim
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
leptomeningeal metastasis
cerebrospinal fluid
extracellular vesicle
biomarker
RNA sequencing
small non-coding RNA
Online Access:https://www.mdpi.com/2072-6694/13/2/209

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