Non-Coding RNAs in the Regulation of Hippocampal Neurogenesis and Potential Treatment Targets for Related Disorders
Non-coding RNAs (ncRNAs), including miRNAs, lncRNAs, circRNAs, and piRNAs, do not encode proteins. Nonetheless, they have critical roles in a variety of cellular activities—such as development, neurogenesis, degeneration, and the response to injury to the nervous system—via protein translation, RNA...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/1/18 |
| _version_ | 1797445535588679680 |
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| author | Zhengye Tan Wen Li Xiang Cheng Qing Zhu Xinhua Zhang |
| author_facet | Zhengye Tan Wen Li Xiang Cheng Qing Zhu Xinhua Zhang |
| author_sort | Zhengye Tan |
| collection | DOAJ |
| description | Non-coding RNAs (ncRNAs), including miRNAs, lncRNAs, circRNAs, and piRNAs, do not encode proteins. Nonetheless, they have critical roles in a variety of cellular activities—such as development, neurogenesis, degeneration, and the response to injury to the nervous system—via protein translation, RNA splicing, gene activation, silencing, modifications, and editing; thus, they may serve as potential targets for disease treatment. The activity of adult neural stem cells (NSCs) in the subgranular zone of the hippocampal dentate gyrus critically influences hippocampal function, including learning, memory, and emotion. ncRNAs have been shown to be involved in the regulation of hippocampal neurogenesis, including proliferation, differentiation, and migration of NSCs and synapse formation. The interaction among ncRNAs is complex and diverse and has become a major topic within the life science. This review outlines advances in research on the roles of ncRNAs in modulating NSC bioactivity in the hippocampus and discusses their potential applications in the treatment of illnesses affecting the hippocampus. |
| first_indexed | 2024-03-09T13:28:11Z |
| format | Article |
| id | doaj.art-6103e75f87d04cf5a3e1b399a70a4b59 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T13:28:11Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-6103e75f87d04cf5a3e1b399a70a4b592023-11-30T21:21:35ZengMDPI AGBiomolecules2218-273X2022-12-011311810.3390/biom13010018Non-Coding RNAs in the Regulation of Hippocampal Neurogenesis and Potential Treatment Targets for Related DisordersZhengye Tan0Wen Li1Xiang Cheng2Qing Zhu3Xinhua Zhang4Department of Anatomy, Institute of Neurobiology, Medical School, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, ChinaDepartment of Anatomy, Institute of Neurobiology, Medical School, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, ChinaDepartment of Anatomy, Institute of Neurobiology, Medical School, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, ChinaSchool of Pharmacy, Nantong University, Nantong 226001, ChinaDepartment of Anatomy, Institute of Neurobiology, Medical School, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, ChinaNon-coding RNAs (ncRNAs), including miRNAs, lncRNAs, circRNAs, and piRNAs, do not encode proteins. Nonetheless, they have critical roles in a variety of cellular activities—such as development, neurogenesis, degeneration, and the response to injury to the nervous system—via protein translation, RNA splicing, gene activation, silencing, modifications, and editing; thus, they may serve as potential targets for disease treatment. The activity of adult neural stem cells (NSCs) in the subgranular zone of the hippocampal dentate gyrus critically influences hippocampal function, including learning, memory, and emotion. ncRNAs have been shown to be involved in the regulation of hippocampal neurogenesis, including proliferation, differentiation, and migration of NSCs and synapse formation. The interaction among ncRNAs is complex and diverse and has become a major topic within the life science. This review outlines advances in research on the roles of ncRNAs in modulating NSC bioactivity in the hippocampus and discusses their potential applications in the treatment of illnesses affecting the hippocampus.https://www.mdpi.com/2218-273X/13/1/18non-coding RNAsneurogenesisneural stem cellhippocampusdifferentiation |
| spellingShingle | Zhengye Tan Wen Li Xiang Cheng Qing Zhu Xinhua Zhang Non-Coding RNAs in the Regulation of Hippocampal Neurogenesis and Potential Treatment Targets for Related Disorders Biomolecules non-coding RNAs neurogenesis neural stem cell hippocampus differentiation |
| title | Non-Coding RNAs in the Regulation of Hippocampal Neurogenesis and Potential Treatment Targets for Related Disorders |
| title_full | Non-Coding RNAs in the Regulation of Hippocampal Neurogenesis and Potential Treatment Targets for Related Disorders |
| title_fullStr | Non-Coding RNAs in the Regulation of Hippocampal Neurogenesis and Potential Treatment Targets for Related Disorders |
| title_full_unstemmed | Non-Coding RNAs in the Regulation of Hippocampal Neurogenesis and Potential Treatment Targets for Related Disorders |
| title_short | Non-Coding RNAs in the Regulation of Hippocampal Neurogenesis and Potential Treatment Targets for Related Disorders |
| title_sort | non coding rnas in the regulation of hippocampal neurogenesis and potential treatment targets for related disorders |
| topic | non-coding RNAs neurogenesis neural stem cell hippocampus differentiation |
| url | https://www.mdpi.com/2218-273X/13/1/18 |
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