The Effect of Clinical, Laboratory and Radiological Findings on Mortality in Patients with Severe COVID-19
Introduction: COVID-19 can range from asymptomatic to critical illness and may result in mortality. In our study, we aimed to evaluate the effect of clinical, laboratory, and radiological findings on mortality in patients diagnosed with severe COVID-19. Materials and Methods: We included SARS-CoV-...
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| Format: | Article |
| Language: | English |
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Bilimsel Tip Yayinevi
2023-09-01
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| Series: | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| Subjects: | |
| Online Access: | http://www.floradergisi.org/managete/fu_folder/2023-03/2023-28-03-371-382.pdf |
| _version_ | 1797676954502037504 |
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| author | Sudem MAHMUTOĞLU ÇOLAK Tuba İLGAR Süleyman Koç Kübra Akyüz Gülsün ÇAKIR ODABAŞ Özcan Yavaş |
| author_facet | Sudem MAHMUTOĞLU ÇOLAK Tuba İLGAR Süleyman Koç Kübra Akyüz Gülsün ÇAKIR ODABAŞ Özcan Yavaş |
| author_sort | Sudem MAHMUTOĞLU ÇOLAK |
| collection | DOAJ |
| description | Introduction: COVID-19 can range from asymptomatic to critical illness and may result in mortality. In our study, we aimed to evaluate the effect of clinical, laboratory, and radiological findings on mortality in patients diagnosed with severe COVID-19.
Materials and Methods: We included SARS-CoV-2 polymerase chain reaction (PCR) positive patients followed up in infectious diseases pandemic and chest diseases pandemic departments at Rize State Hospital in 01.01.2020-31.03.2021. Epidemiological data, chronic diseases, admission symptoms, laboratory findings, and radiological findings of the patients were recorded retrospectively from the patient files. Patients were grouped as survivors and non-survivors. We defined severe disease as patients with pneumonia on radiological imaging, oxygen saturation < 0.05.
Results: 135 patients, 110 of whom were survivors and 25 non-survivors, were included in the study. The mean age was 65.5 ± 15.45 years and 61.5% (n= 83) of patients were male. The mean age of the non-survivors was higher compared to survivors (p= 0.007). The mortality rates in patients with coronary artery disease (CAD) and chronic kidney disease (CKD) were statistically higher in non-survivors (p= 0.032, p= 0.032). The rate of tachypnea was found to be statistically higher in the non-survivors (p= 0.001). During the follow-up period, chest X-rays were taken every other day for assessment. The rate of progression was found to be statistically significantly higher in non-survivors (p= 0.004). According to the results of the multivariate logistic regression analysis, the presence of CAD, tachypnea at hospital admission, and progression in chest X-ray were considered independent risk factors for mortality.
Conclusion: In this study, the factors that may worsen the disease in the severe COVID-19 disease course were estimated and the presence of CAD, tachypnea, and progression in chest X-ray was found to be independent risk factors for mortality. In addition to chronic diseases and symptoms at presentation, the detection of progression in chest X-ray in the clinical follow-up of patients is a risk factor for mortality, which shows us that radiological follow-up should be kept in mind during the course of the disease. |
| first_indexed | 2024-03-11T22:37:57Z |
| format | Article |
| id | doaj.art-6104aaf73eef446caa4b6106a54edba0 |
| institution | Directory Open Access Journal |
| issn | 1300-932X |
| language | English |
| last_indexed | 2024-03-11T22:37:57Z |
| publishDate | 2023-09-01 |
| publisher | Bilimsel Tip Yayinevi |
| record_format | Article |
| series | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| spelling | doaj.art-6104aaf73eef446caa4b6106a54edba02023-09-22T11:19:27ZengBilimsel Tip YayineviFlora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi1300-932X2023-09-0128337138210.5578/flora.20239707The Effect of Clinical, Laboratory and Radiological Findings on Mortality in Patients with Severe COVID-19Sudem MAHMUTOĞLU ÇOLAK0https://orcid.org/0000-0001-7214-2305Tuba İLGAR1https://orcid.org/0000-0003-2476-8295Süleyman Koç2https://orcid.org/0000-0003-0225-2124Kübra Akyüz3https://orcid.org/0000-0002-4952-1689Gülsün ÇAKIR ODABAŞ4https://orcid.org/0000-0002-9815-8150Özcan Yavaş5https://orcid.org/0000-0001-8641-7031Clinic of Infectious Diseases and Clinical Microbiology, Recep Tayyip Erdoğan University Training and Research Hospital, Rize, TürkiyeClinic of Infectious Diseases and Clinical Microbiology, Recep Tayyip Erdoğan University Training and Research Hospital, Rize, TürkiyeClinic of Infectious Diseases and Clinical Microbiology, Rize State Hospital, Rize, TürkiyeClinic of Chest Diseases, Rize State Hospital, Rize, TürkiyeClinic of Chest Diseases, Rize State Hospital, Rize, TürkiyeDepartment of Emergency Medicine, Recep Tayyip Erdoğan University Training and Research Hospital, Rize, TürkiyeIntroduction: COVID-19 can range from asymptomatic to critical illness and may result in mortality. In our study, we aimed to evaluate the effect of clinical, laboratory, and radiological findings on mortality in patients diagnosed with severe COVID-19. Materials and Methods: We included SARS-CoV-2 polymerase chain reaction (PCR) positive patients followed up in infectious diseases pandemic and chest diseases pandemic departments at Rize State Hospital in 01.01.2020-31.03.2021. Epidemiological data, chronic diseases, admission symptoms, laboratory findings, and radiological findings of the patients were recorded retrospectively from the patient files. Patients were grouped as survivors and non-survivors. We defined severe disease as patients with pneumonia on radiological imaging, oxygen saturation < 0.05. Results: 135 patients, 110 of whom were survivors and 25 non-survivors, were included in the study. The mean age was 65.5 ± 15.45 years and 61.5% (n= 83) of patients were male. The mean age of the non-survivors was higher compared to survivors (p= 0.007). The mortality rates in patients with coronary artery disease (CAD) and chronic kidney disease (CKD) were statistically higher in non-survivors (p= 0.032, p= 0.032). The rate of tachypnea was found to be statistically higher in the non-survivors (p= 0.001). During the follow-up period, chest X-rays were taken every other day for assessment. The rate of progression was found to be statistically significantly higher in non-survivors (p= 0.004). According to the results of the multivariate logistic regression analysis, the presence of CAD, tachypnea at hospital admission, and progression in chest X-ray were considered independent risk factors for mortality. Conclusion: In this study, the factors that may worsen the disease in the severe COVID-19 disease course were estimated and the presence of CAD, tachypnea, and progression in chest X-ray was found to be independent risk factors for mortality. In addition to chronic diseases and symptoms at presentation, the detection of progression in chest X-ray in the clinical follow-up of patients is a risk factor for mortality, which shows us that radiological follow-up should be kept in mind during the course of the disease. http://www.floradergisi.org/managete/fu_folder/2023-03/2023-28-03-371-382.pdfsevere covid-19risk factorsmortalityprogression |
| spellingShingle | Sudem MAHMUTOĞLU ÇOLAK Tuba İLGAR Süleyman Koç Kübra Akyüz Gülsün ÇAKIR ODABAŞ Özcan Yavaş The Effect of Clinical, Laboratory and Radiological Findings on Mortality in Patients with Severe COVID-19 Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi severe covid-19 risk factors mortality progression |
| title | The Effect of Clinical, Laboratory and Radiological Findings on Mortality in Patients with Severe COVID-19 |
| title_full | The Effect of Clinical, Laboratory and Radiological Findings on Mortality in Patients with Severe COVID-19 |
| title_fullStr | The Effect of Clinical, Laboratory and Radiological Findings on Mortality in Patients with Severe COVID-19 |
| title_full_unstemmed | The Effect of Clinical, Laboratory and Radiological Findings on Mortality in Patients with Severe COVID-19 |
| title_short | The Effect of Clinical, Laboratory and Radiological Findings on Mortality in Patients with Severe COVID-19 |
| title_sort | effect of clinical laboratory and radiological findings on mortality in patients with severe covid 19 |
| topic | severe covid-19 risk factors mortality progression |
| url | http://www.floradergisi.org/managete/fu_folder/2023-03/2023-28-03-371-382.pdf |
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