Ocular biometrics in eyes with different white-to-white corneal diameter in young myopic adults
Abstract The interactions between white-to-white corneal diameter (WTW) and other ocular biometrics are important for planning of refractive surgery and understanding of ocular structural changes in myopia, but such interactions are rarely investigated in young myopic adults. This is a retrospective...
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| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-55318-9 |
| _version_ | 1827327510187081728 |
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| author | Li Jiang Zijing Du Changting Tang Shanqing Zhu Lu Xiong Xuejun Fang Jin Zhou Qingsong Zhang Wei Sun Qingyan Zeng Xiaohua Lei Zheng Wang Yijun Hu |
| author_facet | Li Jiang Zijing Du Changting Tang Shanqing Zhu Lu Xiong Xuejun Fang Jin Zhou Qingsong Zhang Wei Sun Qingyan Zeng Xiaohua Lei Zheng Wang Yijun Hu |
| author_sort | Li Jiang |
| collection | DOAJ |
| description | Abstract The interactions between white-to-white corneal diameter (WTW) and other ocular biometrics are important for planning of refractive surgery and understanding of ocular structural changes in myopia, but such interactions are rarely investigated in young myopic adults. This is a retrospective study involving 7893 young myopic adults from five centers. WTW and other ocular biometrics were measured by Pentacam. The ocular biometrics included anterior corneal curvature (AK) and posterior corneal curvature (PK), central corneal thickness (CCT) and corneal volume (CV), anterior and corneal eccentricity and asphericity, anterior corneal astigmatism (ACA) and posterior corneal astigmatism, anterior chamber depth (ACD), and anterior chamber volume (ACV). The ocular biometrics were compared among eyes of different WTW quartiles. Multivariate linear regression was used to assess the linear associations between WTW and other ocular biometrics adjusting for age, gender and spherical equivalent. In eyes of different WTW quartiles, other ocular biometrics were also significantly different (all P < 0.05). After adjusting for age, gender and spherical equivalent, WTW was positively correlated to AK (β = 0.26 to 0.29), ACA (β = 0.13), anterior corneal asphericity (β = 0.05), PK (β = 0.33 to 0.34), posterior corneal asphericity (β = 0.13), ACD (β = 0.29), and ACV (β = 40.69), and was negatively correlated to CCT (β = − 6.83), CV (β = − 0.06 to − 0.78), anterior corneal eccentricity (β = − 0.035), and posterior corneal eccentricity (β = − 0.14) (all P < 0.001). In conclusion, we found that in young myopic adults, larger WTW was associated with thinner corneal thickness, flatter corneal curvature, more anterior corneal toricity, less corneal eccentricity and asphericity, and broader anterior chamber. Our findings may fill in the gap of literature, and help us better understand how the anterior segment structures interact with the WTW in myopia. |
| first_indexed | 2024-03-07T15:02:18Z |
| format | Article |
| id | doaj.art-610704f3b9534d9b878faf1f0d4e3468 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:02:18Z |
| publishDate | 2024-02-01 |
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| spelling | doaj.art-610704f3b9534d9b878faf1f0d4e34682024-03-05T19:04:21ZengNature PortfolioScientific Reports2045-23222024-02-011411710.1038/s41598-024-55318-9Ocular biometrics in eyes with different white-to-white corneal diameter in young myopic adultsLi Jiang0Zijing Du1Changting Tang2Shanqing Zhu3Lu Xiong4Xuejun Fang5Jin Zhou6Qingsong Zhang7Wei Sun8Qingyan Zeng9Xiaohua Lei10Zheng Wang11Yijun Hu12Refractive Surgery Center, Hankou Aier Eye HospitalGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityAier Institute of Refractive Surgery, Refractive Surgery Center, Guangzhou Aier Eye HospitalAier Institute of Refractive Surgery, Refractive Surgery Center, Guangzhou Aier Eye HospitalRefractive Surgery Center, Shenyang Aier Eye HospitalRefractive Surgery Center, Chengdu Aier Eye HospitalRefractive Surgery Center, Wuhan Aier Eye HospitalGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityRefractive Surgery Center, Hankou Aier Eye HospitalRefractive Surgery Center, Hankou Aier Eye HospitalAier Institute of Refractive Surgery, Refractive Surgery Center, Guangzhou Aier Eye HospitalGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityAbstract The interactions between white-to-white corneal diameter (WTW) and other ocular biometrics are important for planning of refractive surgery and understanding of ocular structural changes in myopia, but such interactions are rarely investigated in young myopic adults. This is a retrospective study involving 7893 young myopic adults from five centers. WTW and other ocular biometrics were measured by Pentacam. The ocular biometrics included anterior corneal curvature (AK) and posterior corneal curvature (PK), central corneal thickness (CCT) and corneal volume (CV), anterior and corneal eccentricity and asphericity, anterior corneal astigmatism (ACA) and posterior corneal astigmatism, anterior chamber depth (ACD), and anterior chamber volume (ACV). The ocular biometrics were compared among eyes of different WTW quartiles. Multivariate linear regression was used to assess the linear associations between WTW and other ocular biometrics adjusting for age, gender and spherical equivalent. In eyes of different WTW quartiles, other ocular biometrics were also significantly different (all P < 0.05). After adjusting for age, gender and spherical equivalent, WTW was positively correlated to AK (β = 0.26 to 0.29), ACA (β = 0.13), anterior corneal asphericity (β = 0.05), PK (β = 0.33 to 0.34), posterior corneal asphericity (β = 0.13), ACD (β = 0.29), and ACV (β = 40.69), and was negatively correlated to CCT (β = − 6.83), CV (β = − 0.06 to − 0.78), anterior corneal eccentricity (β = − 0.035), and posterior corneal eccentricity (β = − 0.14) (all P < 0.001). In conclusion, we found that in young myopic adults, larger WTW was associated with thinner corneal thickness, flatter corneal curvature, more anterior corneal toricity, less corneal eccentricity and asphericity, and broader anterior chamber. Our findings may fill in the gap of literature, and help us better understand how the anterior segment structures interact with the WTW in myopia.https://doi.org/10.1038/s41598-024-55318-9Ocular biometricsCorneal biometricsRefractive surgeryWhite-to-white corneal diameter (WTW)Myopia |
| spellingShingle | Li Jiang Zijing Du Changting Tang Shanqing Zhu Lu Xiong Xuejun Fang Jin Zhou Qingsong Zhang Wei Sun Qingyan Zeng Xiaohua Lei Zheng Wang Yijun Hu Ocular biometrics in eyes with different white-to-white corneal diameter in young myopic adults Scientific Reports Ocular biometrics Corneal biometrics Refractive surgery White-to-white corneal diameter (WTW) Myopia |
| title | Ocular biometrics in eyes with different white-to-white corneal diameter in young myopic adults |
| title_full | Ocular biometrics in eyes with different white-to-white corneal diameter in young myopic adults |
| title_fullStr | Ocular biometrics in eyes with different white-to-white corneal diameter in young myopic adults |
| title_full_unstemmed | Ocular biometrics in eyes with different white-to-white corneal diameter in young myopic adults |
| title_short | Ocular biometrics in eyes with different white-to-white corneal diameter in young myopic adults |
| title_sort | ocular biometrics in eyes with different white to white corneal diameter in young myopic adults |
| topic | Ocular biometrics Corneal biometrics Refractive surgery White-to-white corneal diameter (WTW) Myopia |
| url | https://doi.org/10.1038/s41598-024-55318-9 |
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