Mammary Carcinoma Arising in Microglandular Adenosis: A Report of Five Cases
Mammary carcinoma arising in microglandular adenosis (MGA) is extremely rare, and MGA is regarded as a non-obligate precursor of triple-negative breast cancer. We report five cases of carcinoma arising in MGA of the breast. All cases showed a spectrum of proliferative lesions ranging from MGA to aty...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Korean Society of Pathologists & the Korean Society for Cytopathology
2017-07-01
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| Series: | Journal of Pathology and Translational Medicine |
| Subjects: | |
| Online Access: | http://www.jpatholtm.org/upload/pdf/jptm-2016-11-11.pdf |
| _version_ | 1819128564887322624 |
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| author | Mimi Kim Milim Kim Yul Ri Chung So Yeon Park |
| author_facet | Mimi Kim Milim Kim Yul Ri Chung So Yeon Park |
| author_sort | Mimi Kim |
| collection | DOAJ |
| description | Mammary carcinoma arising in microglandular adenosis (MGA) is extremely rare, and MGA is regarded as a non-obligate precursor of triple-negative breast cancer. We report five cases of carcinoma arising in MGA of the breast. All cases showed a spectrum of proliferative lesions ranging from MGA to atypical MGA, ductal carcinoma in situ or invasive carcinoma. Immunohistochemically, all cases were triple-negative and expression of S-100 protein gradually decreased as the lesions progressed from MGA to atypical MGA and carcinoma. Three cases showed acinic cell differentiation with reactivity to α1-antitrypsin, and one case was metaplastic carcinoma. During clinical follow-up, one patient developed local recurrence. Carcinoma arising in MGA is a rare but distinct subset of triple-negative breast cancer with characteristic histologic and immunohistochemical findings. |
| first_indexed | 2024-12-22T08:29:50Z |
| format | Article |
| id | doaj.art-610712ba4de040c887dcce7e517513c8 |
| institution | Directory Open Access Journal |
| issn | 2383-7837 2383-7845 |
| language | English |
| last_indexed | 2024-12-22T08:29:50Z |
| publishDate | 2017-07-01 |
| publisher | Korean Society of Pathologists & the Korean Society for Cytopathology |
| record_format | Article |
| series | Journal of Pathology and Translational Medicine |
| spelling | doaj.art-610712ba4de040c887dcce7e517513c82022-12-21T18:32:31ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452017-07-0151442242710.4132/jptm.2016.11.1116680Mammary Carcinoma Arising in Microglandular Adenosis: A Report of Five CasesMimi Kim0Milim Kim1Yul Ri Chung2So Yeon Park3 Department of Pathology, Seoul National University College of Medicine, Seoul, Korea Department of Pathology, Seoul National University College of Medicine, Seoul, Korea Department of Pathology, Seoul National University College of Medicine, Seoul, Korea Department of Pathology, Seoul National University College of Medicine, Seoul, KoreaMammary carcinoma arising in microglandular adenosis (MGA) is extremely rare, and MGA is regarded as a non-obligate precursor of triple-negative breast cancer. We report five cases of carcinoma arising in MGA of the breast. All cases showed a spectrum of proliferative lesions ranging from MGA to atypical MGA, ductal carcinoma in situ or invasive carcinoma. Immunohistochemically, all cases were triple-negative and expression of S-100 protein gradually decreased as the lesions progressed from MGA to atypical MGA and carcinoma. Three cases showed acinic cell differentiation with reactivity to α1-antitrypsin, and one case was metaplastic carcinoma. During clinical follow-up, one patient developed local recurrence. Carcinoma arising in MGA is a rare but distinct subset of triple-negative breast cancer with characteristic histologic and immunohistochemical findings.http://www.jpatholtm.org/upload/pdf/jptm-2016-11-11.pdfMicroglandular adenosisBreastCarcinoma |
| spellingShingle | Mimi Kim Milim Kim Yul Ri Chung So Yeon Park Mammary Carcinoma Arising in Microglandular Adenosis: A Report of Five Cases Journal of Pathology and Translational Medicine Microglandular adenosis Breast Carcinoma |
| title | Mammary Carcinoma Arising in Microglandular Adenosis: A Report of Five Cases |
| title_full | Mammary Carcinoma Arising in Microglandular Adenosis: A Report of Five Cases |
| title_fullStr | Mammary Carcinoma Arising in Microglandular Adenosis: A Report of Five Cases |
| title_full_unstemmed | Mammary Carcinoma Arising in Microglandular Adenosis: A Report of Five Cases |
| title_short | Mammary Carcinoma Arising in Microglandular Adenosis: A Report of Five Cases |
| title_sort | mammary carcinoma arising in microglandular adenosis a report of five cases |
| topic | Microglandular adenosis Breast Carcinoma |
| url | http://www.jpatholtm.org/upload/pdf/jptm-2016-11-11.pdf |
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