Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T cells during infection are directly associated with level of circulating parasites.
Circulation CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs) have been associated with the delicate balancing between control of overwhelming acute malaria infection and prevention of immune pathology due to disproportionate inflammatory responses to erythrocytic stage of the parasite. While the rol...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2010-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2835751?pdf=render |
| _version_ | 1811268293342789632 |
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| author | Lilian Lacerda Bueno Cristiane Guimarães Morais Fernanda Fortes Araújo Juliana Assis Silva Gomes Rodrigo Corrêa-Oliveira Irene Silva Soares Marcus Vinícius Lacerda Ricardo Toshio Fujiwara Erika Martins Braga |
| author_facet | Lilian Lacerda Bueno Cristiane Guimarães Morais Fernanda Fortes Araújo Juliana Assis Silva Gomes Rodrigo Corrêa-Oliveira Irene Silva Soares Marcus Vinícius Lacerda Ricardo Toshio Fujiwara Erika Martins Braga |
| author_sort | Lilian Lacerda Bueno |
| collection | DOAJ |
| description | Circulation CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs) have been associated with the delicate balancing between control of overwhelming acute malaria infection and prevention of immune pathology due to disproportionate inflammatory responses to erythrocytic stage of the parasite. While the role of Tregs has been well-documented in murine models and P. falciparum infection, the phenotype and function of Tregs in P. vivax infection is still poorly characterized. In the current study, we demonstrated that patients with acute P. vivax infection presented a significant augmentation of circulating Tregs producing anti-inflammatory (IL-10 and TGF-beta) as well as pro-inflammatory (IFN-gamma, IL-17) cytokines, which was further positively correlated with parasite burden. Surface expression of GITR molecule and intracellular expression of CTLA-4 were significantly upregulated in Tregs from infected donors, presenting also a positive association between either absolute numbers of CD4(+)CD25(+)FoxP3(+)GITR(+) or CD4(+)CD25(+)FoxP3(+)CTLA-4(+) and parasite load. Finally, we demonstrate a suppressive effect of Treg cells in specific T cell proliferative responses of P. vivax infected subjects after antigen stimulation with Pv-AMA-1. Our findings indicate that malaria vivax infection lead to an increased number of activated Treg cells that are highly associated with parasite load, which probably exert an important contribution to the modulation of immune responses during P. vivax infection. |
| first_indexed | 2024-04-12T21:20:21Z |
| format | Article |
| id | doaj.art-61079170d7a5421f8f7b6297a6fb9e19 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T21:20:21Z |
| publishDate | 2010-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-61079170d7a5421f8f7b6297a6fb9e192022-12-22T03:16:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-01-0153e962310.1371/journal.pone.0009623Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T cells during infection are directly associated with level of circulating parasites.Lilian Lacerda BuenoCristiane Guimarães MoraisFernanda Fortes AraújoJuliana Assis Silva GomesRodrigo Corrêa-OliveiraIrene Silva SoaresMarcus Vinícius LacerdaRicardo Toshio FujiwaraErika Martins BragaCirculation CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs) have been associated with the delicate balancing between control of overwhelming acute malaria infection and prevention of immune pathology due to disproportionate inflammatory responses to erythrocytic stage of the parasite. While the role of Tregs has been well-documented in murine models and P. falciparum infection, the phenotype and function of Tregs in P. vivax infection is still poorly characterized. In the current study, we demonstrated that patients with acute P. vivax infection presented a significant augmentation of circulating Tregs producing anti-inflammatory (IL-10 and TGF-beta) as well as pro-inflammatory (IFN-gamma, IL-17) cytokines, which was further positively correlated with parasite burden. Surface expression of GITR molecule and intracellular expression of CTLA-4 were significantly upregulated in Tregs from infected donors, presenting also a positive association between either absolute numbers of CD4(+)CD25(+)FoxP3(+)GITR(+) or CD4(+)CD25(+)FoxP3(+)CTLA-4(+) and parasite load. Finally, we demonstrate a suppressive effect of Treg cells in specific T cell proliferative responses of P. vivax infected subjects after antigen stimulation with Pv-AMA-1. Our findings indicate that malaria vivax infection lead to an increased number of activated Treg cells that are highly associated with parasite load, which probably exert an important contribution to the modulation of immune responses during P. vivax infection.http://europepmc.org/articles/PMC2835751?pdf=render |
| spellingShingle | Lilian Lacerda Bueno Cristiane Guimarães Morais Fernanda Fortes Araújo Juliana Assis Silva Gomes Rodrigo Corrêa-Oliveira Irene Silva Soares Marcus Vinícius Lacerda Ricardo Toshio Fujiwara Erika Martins Braga Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T cells during infection are directly associated with level of circulating parasites. PLoS ONE |
| title | Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T cells during infection are directly associated with level of circulating parasites. |
| title_full | Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T cells during infection are directly associated with level of circulating parasites. |
| title_fullStr | Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T cells during infection are directly associated with level of circulating parasites. |
| title_full_unstemmed | Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T cells during infection are directly associated with level of circulating parasites. |
| title_short | Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T cells during infection are directly associated with level of circulating parasites. |
| title_sort | plasmodium vivax induction of cd4 cd25 foxp3 regulatory t cells during infection are directly associated with level of circulating parasites |
| url | http://europepmc.org/articles/PMC2835751?pdf=render |
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