Characterization and cytotoxicity and antihuman renal cell carcinoma potentials of starch capped-copper oxide nanoparticles synthesized by ultrasonic irradiation: Introducing a novel chemotherapeutic drug
In this research article we have demonstrated the sustainable green synthesis of a novel starch templated CuO NP following a clean and non-hazardous pathway. Ultrasonic irradiation was used to promote the reaction in alkaline medium. The numerous hydroxyl groups present in starch was exploited in th...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Journal of Saudi Chemical Society |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610322001259 |
| _version_ | 1797980739151593472 |
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| author | Jianguo Zheng Bikash Karmakar Attalla F. El-kott Fahmy G. Elsaid Ali A. Shati Sally Negm Abdulrahman A. Alsayegh Gaber El-Saber Batiha |
| author_facet | Jianguo Zheng Bikash Karmakar Attalla F. El-kott Fahmy G. Elsaid Ali A. Shati Sally Negm Abdulrahman A. Alsayegh Gaber El-Saber Batiha |
| author_sort | Jianguo Zheng |
| collection | DOAJ |
| description | In this research article we have demonstrated the sustainable green synthesis of a novel starch templated CuO NP following a clean and non-hazardous pathway. Ultrasonic irradiation was used to promote the reaction in alkaline medium. The numerous hydroxyl groups present in starch was exploited in the green reduction of immobilized copper ions in situ. They also helped to stabilize the as synthesized Cu NPs by encapsulation or capping. The morphology and physicochemical characteristics were ascertained over an array of analytical techniques like Scanning Electron Microscopy (SEM), Energy-Dispersive X-ray Spectroscopy (EDS), Elemental Mapping, Transmission Electron Microscopy (TEM), X-ray Diffraction (XRD), and Inductively Coupled Plasma-Atomic Emission Spectrometry (ICP-AES). Biologically, the nanocomposite exhibited excellent cytotoxicity against human renal cell carcinoma (RCC-GH, CaKi-2 and HEK293) cell lines without affecting the normal (HUVEC) cell line. IC50 values of the nanocomposite were found at 139, 208and 125 against RCC-GH, CaKi-2 and HEK293 cell lines respectively and accordingly, HEK293 afforded the best adenocarcinoma activity. |
| first_indexed | 2024-04-11T05:58:34Z |
| format | Article |
| id | doaj.art-6108b147edac472ca960c0bd90fb8dc3 |
| institution | Directory Open Access Journal |
| issn | 1319-6103 |
| language | English |
| last_indexed | 2024-04-11T05:58:34Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj.art-6108b147edac472ca960c0bd90fb8dc32022-12-22T04:41:48ZengElsevierJournal of Saudi Chemical Society1319-61032022-11-01266101543Characterization and cytotoxicity and antihuman renal cell carcinoma potentials of starch capped-copper oxide nanoparticles synthesized by ultrasonic irradiation: Introducing a novel chemotherapeutic drugJianguo Zheng0Bikash Karmakar1Attalla F. El-kott2Fahmy G. Elsaid3Ali A. Shati4Sally Negm5Abdulrahman A. Alsayegh6Gaber El-Saber Batiha7Department of Nephrology, Zhumadian Central Hospial, Jiefang Dadao, Yicheng District, Zhumadian City, Henan Province 463000, ChinaDepartment of Chemistry, Gobardanga Hindu College, 24-Parganas (North), India; Corresponding author.Department of Biology, College of Science, King Khalid University, Abha, Saudi Arabia; Department of Zoology, Faculty of Science, Damanhour University, Damanhour, EgyptDepartment of Biology, College of Science, King Khalid University, Abha, Saudi Arabia; Department of Zoology, Faculty of Science, Mansoura University, Mansoura, EgyptDepartment of Biology, College of Science, King Khalid University, Abha, Saudi ArabiaDepartment of Life Sciences, Faculty of Science and Art Mahail, King Khalid University, Saudi Arabia; Unit of Food Bacteriology, Central Laboratory of Food Hygiene, Ministry of Health, Sharkia 44516, EgyptDepartment of Clinical Nutrition, Applied Medical Sciences College, Jazan University, Jazan 82817, Saudi ArabiaDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, AlBeheira, EgyptIn this research article we have demonstrated the sustainable green synthesis of a novel starch templated CuO NP following a clean and non-hazardous pathway. Ultrasonic irradiation was used to promote the reaction in alkaline medium. The numerous hydroxyl groups present in starch was exploited in the green reduction of immobilized copper ions in situ. They also helped to stabilize the as synthesized Cu NPs by encapsulation or capping. The morphology and physicochemical characteristics were ascertained over an array of analytical techniques like Scanning Electron Microscopy (SEM), Energy-Dispersive X-ray Spectroscopy (EDS), Elemental Mapping, Transmission Electron Microscopy (TEM), X-ray Diffraction (XRD), and Inductively Coupled Plasma-Atomic Emission Spectrometry (ICP-AES). Biologically, the nanocomposite exhibited excellent cytotoxicity against human renal cell carcinoma (RCC-GH, CaKi-2 and HEK293) cell lines without affecting the normal (HUVEC) cell line. IC50 values of the nanocomposite were found at 139, 208and 125 against RCC-GH, CaKi-2 and HEK293 cell lines respectively and accordingly, HEK293 afforded the best adenocarcinoma activity.http://www.sciencedirect.com/science/article/pii/S1319610322001259StarchCuO NPsHuman renal adenocarcinomaIn vitro condition |
| spellingShingle | Jianguo Zheng Bikash Karmakar Attalla F. El-kott Fahmy G. Elsaid Ali A. Shati Sally Negm Abdulrahman A. Alsayegh Gaber El-Saber Batiha Characterization and cytotoxicity and antihuman renal cell carcinoma potentials of starch capped-copper oxide nanoparticles synthesized by ultrasonic irradiation: Introducing a novel chemotherapeutic drug Journal of Saudi Chemical Society Starch CuO NPs Human renal adenocarcinoma In vitro condition |
| title | Characterization and cytotoxicity and antihuman renal cell carcinoma potentials of starch capped-copper oxide nanoparticles synthesized by ultrasonic irradiation: Introducing a novel chemotherapeutic drug |
| title_full | Characterization and cytotoxicity and antihuman renal cell carcinoma potentials of starch capped-copper oxide nanoparticles synthesized by ultrasonic irradiation: Introducing a novel chemotherapeutic drug |
| title_fullStr | Characterization and cytotoxicity and antihuman renal cell carcinoma potentials of starch capped-copper oxide nanoparticles synthesized by ultrasonic irradiation: Introducing a novel chemotherapeutic drug |
| title_full_unstemmed | Characterization and cytotoxicity and antihuman renal cell carcinoma potentials of starch capped-copper oxide nanoparticles synthesized by ultrasonic irradiation: Introducing a novel chemotherapeutic drug |
| title_short | Characterization and cytotoxicity and antihuman renal cell carcinoma potentials of starch capped-copper oxide nanoparticles synthesized by ultrasonic irradiation: Introducing a novel chemotherapeutic drug |
| title_sort | characterization and cytotoxicity and antihuman renal cell carcinoma potentials of starch capped copper oxide nanoparticles synthesized by ultrasonic irradiation introducing a novel chemotherapeutic drug |
| topic | Starch CuO NPs Human renal adenocarcinoma In vitro condition |
| url | http://www.sciencedirect.com/science/article/pii/S1319610322001259 |
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