Novel inhibitors of cholesterol degradation in Mycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment.

Novel inhibitors of cholesterol degradation in Mycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment.

Mycobacterium tuberculosis (Mtb) relies on a specialized set of metabolic pathways to support growth in macrophages. By conducting an extensive, unbiased chemical screen to identify small molecules that inhibit Mtb metabolism within macrophages, we identified a significant number of novel compounds...

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Bibliographic Details
Main Authors: Brian C VanderVen, Ruth J Fahey, Wonsik Lee, Yancheng Liu, Robert B Abramovitch, Christine Memmott, Adam M Crowe, Lindsay D Eltis, Emanuele Perola, David D Deininger, Tiansheng Wang, Christopher P Locher, David G Russell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4335503?pdf=render

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