IL-1β production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease.

IL-1β production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease.

Chronic hepatitis C virus (HCV) infection is a leading cause of liver disease. Liver inflammation underlies infection-induced fibrosis, cirrhosis and liver cancer but the processes that promote hepatic inflammation by HCV are not defined. We provide a systems biology analysis with multiple lines of...

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Bibliographic Details
Main Authors: Amina A Negash, Hilario J Ramos, Nanette Crochet, Daryl T Y Lau, Brian Doehle, Neven Papic, Don A Delker, Juandy Jo, Antonio Bertoletti, Curt H Hagedorn, Michael Gale
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3635973?pdf=render

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