Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: Varying the number of double-stranded RNA binding domains and lineage-specific duplications

Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: Varying the number of double-stranded RNA binding domains and lineage-specific duplications

<p>Abstract</p> <p>Background</p> <p>Double-stranded (ds) RNA, generated during viral infection, binds and activates the mammalian anti-viral protein kinase PKR, which phosphorylates the translation initiation factor eIF2α leading to the general inhibition of protein sy...

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Bibliographic Details
Main Authors: Dever Thomas E, Dey Madhusudan, Deigendesch Nikolaus, Rothenburg Stefan, Tazi Loubna
Format: Article
Language:English
Published: BMC 2008-03-01
Series:BMC Biology
Online Access:http://www.biomedcentral.com/1741-7007/6/12

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