Prospective Memory and Regional Functional Connectivity in Subcortical Ischemic Vascular Disease
Objectives: Patients with subcortical ischemic vascular disease (SIVD) often have prominent frontal dysfunction. However, it remains unclear how SIVD affects prospective memory (PM), which strongly relies on the frontoparietal network. The present study aimed to investigate PM performance in patient...
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| Format: | Article |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.686040/full |
| _version_ | 1819134107461877760 |
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| author | Xuan-Miao Zhuang Li-Wei Kuo Li-Wei Kuo Shih-Yen Lin Jir-Jei Yang Min-Chien Tu Min-Chien Tu Yen-Hsuan Hsu Yen-Hsuan Hsu |
| author_facet | Xuan-Miao Zhuang Li-Wei Kuo Li-Wei Kuo Shih-Yen Lin Jir-Jei Yang Min-Chien Tu Min-Chien Tu Yen-Hsuan Hsu Yen-Hsuan Hsu |
| author_sort | Xuan-Miao Zhuang |
| collection | DOAJ |
| description | Objectives: Patients with subcortical ischemic vascular disease (SIVD) often have prominent frontal dysfunction. However, it remains unclear how SIVD affects prospective memory (PM), which strongly relies on the frontoparietal network. The present study aimed to investigate PM performance in patients with early stage SIVD as compared to those with Alzheimer's disease (AD) and to older adults with normal cognition, and to explore the neural correlates of PM deficits.Method: Patients with very-mild to mild dementia due to SIVD or AD and normal controls (NC) aged above 60 years were recruited. Seventy-three participants (20 SIVD, 22 AD, and 31 NC) underwent structural magnetic resonance imaging (MRI), cognitive screening tests, and a computerized PM test. Sixty-five of these participants (19 SIVD, 20 AD, and 26 NC) also received resting-state functional MRI.Results: The group with SIVD had significantly fewer PM hits than the control group on both time-based and non-focal event-based PM tasks. Among patients in the very early stage, only those with SIVD but not AD performed significantly worse than the controls. Correlational analyses showed that non-focal event-based PM in SIVD was positively correlated with regional homogeneity in bilateral superior and middle frontal gyri, while time-based PM was not significantly associated with regional homogeneity in any of the regions of interest within the dorsal frontoparietal regions.Conclusions: The findings of this study highlight the vulnerability of non-focal event-based PM to the disruption of regional functional connectivity in bilateral superior and middle frontal gyri in patients with SIVD. |
| first_indexed | 2024-12-22T09:57:56Z |
| format | Article |
| id | doaj.art-610f90a9a4694391be625110548058f5 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-22T09:57:56Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-610f90a9a4694391be625110548058f52022-12-21T18:30:14ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-08-011310.3389/fnagi.2021.686040686040Prospective Memory and Regional Functional Connectivity in Subcortical Ischemic Vascular DiseaseXuan-Miao Zhuang0Li-Wei Kuo1Li-Wei Kuo2Shih-Yen Lin3Jir-Jei Yang4Min-Chien Tu5Min-Chien Tu6Yen-Hsuan Hsu7Yen-Hsuan Hsu8Department of Psychology, National Chung Cheng University, Chiayi, TaiwanInstitute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, TaiwanInstitute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Computer Science, National Chiao Tung University, Hsinchu, TaiwanDepartment of Medical Imaging, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, TaiwanDepartment of Neurology, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, TaiwanDepartment of Neurology, School of Medicine, Tzu Chi University, Hualien, TaiwanDepartment of Psychology, National Chung Cheng University, Chiayi, TaiwanCenter for Innovative Research on Aging Society (CIRAS), National Chung Cheng University, Chiayi, TaiwanObjectives: Patients with subcortical ischemic vascular disease (SIVD) often have prominent frontal dysfunction. However, it remains unclear how SIVD affects prospective memory (PM), which strongly relies on the frontoparietal network. The present study aimed to investigate PM performance in patients with early stage SIVD as compared to those with Alzheimer's disease (AD) and to older adults with normal cognition, and to explore the neural correlates of PM deficits.Method: Patients with very-mild to mild dementia due to SIVD or AD and normal controls (NC) aged above 60 years were recruited. Seventy-three participants (20 SIVD, 22 AD, and 31 NC) underwent structural magnetic resonance imaging (MRI), cognitive screening tests, and a computerized PM test. Sixty-five of these participants (19 SIVD, 20 AD, and 26 NC) also received resting-state functional MRI.Results: The group with SIVD had significantly fewer PM hits than the control group on both time-based and non-focal event-based PM tasks. Among patients in the very early stage, only those with SIVD but not AD performed significantly worse than the controls. Correlational analyses showed that non-focal event-based PM in SIVD was positively correlated with regional homogeneity in bilateral superior and middle frontal gyri, while time-based PM was not significantly associated with regional homogeneity in any of the regions of interest within the dorsal frontoparietal regions.Conclusions: The findings of this study highlight the vulnerability of non-focal event-based PM to the disruption of regional functional connectivity in bilateral superior and middle frontal gyri in patients with SIVD.https://www.frontiersin.org/articles/10.3389/fnagi.2021.686040/fullsubcortical ischemic vascular diseasesmall vessel diseasevascular cognitive impairmentprospective memoryneuropsychological functionfunctional connectivity |
| spellingShingle | Xuan-Miao Zhuang Li-Wei Kuo Li-Wei Kuo Shih-Yen Lin Jir-Jei Yang Min-Chien Tu Min-Chien Tu Yen-Hsuan Hsu Yen-Hsuan Hsu Prospective Memory and Regional Functional Connectivity in Subcortical Ischemic Vascular Disease Frontiers in Aging Neuroscience subcortical ischemic vascular disease small vessel disease vascular cognitive impairment prospective memory neuropsychological function functional connectivity |
| title | Prospective Memory and Regional Functional Connectivity in Subcortical Ischemic Vascular Disease |
| title_full | Prospective Memory and Regional Functional Connectivity in Subcortical Ischemic Vascular Disease |
| title_fullStr | Prospective Memory and Regional Functional Connectivity in Subcortical Ischemic Vascular Disease |
| title_full_unstemmed | Prospective Memory and Regional Functional Connectivity in Subcortical Ischemic Vascular Disease |
| title_short | Prospective Memory and Regional Functional Connectivity in Subcortical Ischemic Vascular Disease |
| title_sort | prospective memory and regional functional connectivity in subcortical ischemic vascular disease |
| topic | subcortical ischemic vascular disease small vessel disease vascular cognitive impairment prospective memory neuropsychological function functional connectivity |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.686040/full |
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