Candidalysin: From Mechanism of Action to Biomarker Development and Therapeutic Response
The incidence of systemic fungal infection is increasing, and millions of people around the world suffer from fungal infections. Candida albicans is one of the most frequently isolated fungal pathogens in clinical settings. As a polymorphic organism, the transition between yeast and hyphae is critic...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Innovative Healthcare Institute
2021-01-01
|
| Series: | Innovations in Digital Health, Diagnostics, and Biomarkers |
| Subjects: | |
| Online Access: | https://theijpt.org/doi/pdf/10.36401/IDDB-20-02 |
| _version_ | 1828121146739916800 |
|---|---|
| author | Yao-Qi Chen Qian Li Tian-Yi Zhang Ning-Ning Liu |
| author_facet | Yao-Qi Chen Qian Li Tian-Yi Zhang Ning-Ning Liu |
| author_sort | Yao-Qi Chen |
| collection | DOAJ |
| description | The incidence of systemic fungal infection is increasing, and millions of people around the world suffer from fungal infections. Candida albicans is one of the most frequently isolated fungal pathogens in clinical settings. As a polymorphic organism, the transition between yeast and hyphae is critical for C. albicans virulence and pathogenesis. However, the mechanism of hyphae-associated virulence remains unclear. Candidalysin is the first human fungal cytolytic peptide toxin originating from the hyphae-specific gene, ECE1. This review will summarize the most recent progress underlying candidalysin-mediated epithelial damage and host defense pathways, which might shed new light on the development of a novel antifungal strategy and early diagnostic biomarker. |
| first_indexed | 2024-04-11T14:17:41Z |
| format | Article |
| id | doaj.art-6110e83bbbe345cca55cbea6ebbde251 |
| institution | Directory Open Access Journal |
| issn | 2688-8130 |
| language | English |
| last_indexed | 2024-04-11T14:17:41Z |
| publishDate | 2021-01-01 |
| publisher | Innovative Healthcare Institute |
| record_format | Article |
| series | Innovations in Digital Health, Diagnostics, and Biomarkers |
| spelling | doaj.art-6110e83bbbe345cca55cbea6ebbde2512022-12-22T04:19:13ZengInnovative Healthcare InstituteInnovations in Digital Health, Diagnostics, and Biomarkers2688-81302021-01-0112414410.36401/IDDB-20-02i2688-8130-1-2-41Candidalysin: From Mechanism of Action to Biomarker Development and Therapeutic ResponseYao-Qi ChenQian LiTian-Yi ZhangNing-Ning LiuThe incidence of systemic fungal infection is increasing, and millions of people around the world suffer from fungal infections. Candida albicans is one of the most frequently isolated fungal pathogens in clinical settings. As a polymorphic organism, the transition between yeast and hyphae is critical for C. albicans virulence and pathogenesis. However, the mechanism of hyphae-associated virulence remains unclear. Candidalysin is the first human fungal cytolytic peptide toxin originating from the hyphae-specific gene, ECE1. This review will summarize the most recent progress underlying candidalysin-mediated epithelial damage and host defense pathways, which might shed new light on the development of a novel antifungal strategy and early diagnostic biomarker.https://theijpt.org/doi/pdf/10.36401/IDDB-20-02candidalysincandida albicanscytolytic peptide toxinfungal infectionece1 |
| spellingShingle | Yao-Qi Chen Qian Li Tian-Yi Zhang Ning-Ning Liu Candidalysin: From Mechanism of Action to Biomarker Development and Therapeutic Response Innovations in Digital Health, Diagnostics, and Biomarkers candidalysin candida albicans cytolytic peptide toxin fungal infection ece1 |
| title | Candidalysin: From Mechanism of Action to Biomarker Development and Therapeutic Response |
| title_full | Candidalysin: From Mechanism of Action to Biomarker Development and Therapeutic Response |
| title_fullStr | Candidalysin: From Mechanism of Action to Biomarker Development and Therapeutic Response |
| title_full_unstemmed | Candidalysin: From Mechanism of Action to Biomarker Development and Therapeutic Response |
| title_short | Candidalysin: From Mechanism of Action to Biomarker Development and Therapeutic Response |
| title_sort | candidalysin from mechanism of action to biomarker development and therapeutic response |
| topic | candidalysin candida albicans cytolytic peptide toxin fungal infection ece1 |
| url | https://theijpt.org/doi/pdf/10.36401/IDDB-20-02 |
| work_keys_str_mv | AT yaoqichen candidalysinfrommechanismofactiontobiomarkerdevelopmentandtherapeuticresponse AT qianli candidalysinfrommechanismofactiontobiomarkerdevelopmentandtherapeuticresponse AT tianyizhang candidalysinfrommechanismofactiontobiomarkerdevelopmentandtherapeuticresponse AT ningningliu candidalysinfrommechanismofactiontobiomarkerdevelopmentandtherapeuticresponse |