Association between Physical Activity and Non-Alcoholic Fatty Liver Disease in Adults with Metabolic Syndrome: The FLIPAN Study
Background: A lifestyle with regular PA (physical activity) and Mediterranean diet has benefits on NAFLD (non-alcoholic fatty liver disease) and MetS (metabolic syndrome). Objectives: To assess the association between physical activity and NAFLD in adults with MetS. Design: Cross-sectional study in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/5/1063 |
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| author | Catalina M. Mascaró Cristina Bouzas Sofia Montemayor Miguel Casares Cristina Gómez Lucía Ugarriza Pere-Antoni Borràs José Alfredo Martínez Josep A. Tur |
| author_facet | Catalina M. Mascaró Cristina Bouzas Sofia Montemayor Miguel Casares Cristina Gómez Lucía Ugarriza Pere-Antoni Borràs José Alfredo Martínez Josep A. Tur |
| author_sort | Catalina M. Mascaró |
| collection | DOAJ |
| description | Background: A lifestyle with regular PA (physical activity) and Mediterranean diet has benefits on NAFLD (non-alcoholic fatty liver disease) and MetS (metabolic syndrome). Objectives: To assess the association between physical activity and NAFLD in adults with MetS. Design: Cross-sectional study in 155 participants (40–60 years old) from Balearic Islands and Navarra (Spain) with diagnosis of NAFLD and MetS, and BMI (body mass index) between 27 and 40 Kg/m<sup>2</sup>. Methods: PA level was categorized into two groups according to weekly METs (metabolic equivalents of tasks). PA was assessed using a validated Minnesota questionnaire and accelerometers. MetS parameters were assessed by blood collection analysis and NAFLD by abdominal MRI (magnetic resonance imaging). Results: Participants with high PA showed more energy expenditure and expended more calories than ingested (−143.9 Kcal/day; <i>p</i> < 0.001). PA was a risk factor for AST (aspartate aminotransferase) (adjusted OR: 7.26; 95% CI: 1.79–29.40) and a protective factor for ALT (alanine aminotransferase) (adjusted OR: 0.24; 95% CI: 0.12–0.48), GGT (gamma-glutamyl transferase) (adjusted OR: 0.52; 95% CI: 0.29–0.94) and IFC-NMR (intrahepatic fat content by nuclear magnetic resonance) (adjusted OR: 0.26; 95% CI: 0.12–0.56) when sociodemographic confounders were considered. Conclusions: NAFLD patients with high PA showed more positive relationship on MetS parameters and liver profile (ALT, GGT, IFC-NMR) than subjects with low PA, but not for AST. Difference between calories ingested and expended influenced this relationship. |
| first_indexed | 2024-03-09T20:26:07Z |
| format | Article |
| id | doaj.art-61118d0c730343c18d7b6436c70d338a |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T20:26:07Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-61118d0c730343c18d7b6436c70d338a2023-11-23T23:33:57ZengMDPI AGNutrients2072-66432022-03-01145106310.3390/nu14051063Association between Physical Activity and Non-Alcoholic Fatty Liver Disease in Adults with Metabolic Syndrome: The FLIPAN StudyCatalina M. Mascaró0Cristina Bouzas1Sofia Montemayor2Miguel Casares3Cristina Gómez4Lucía Ugarriza5Pere-Antoni Borràs6José Alfredo Martínez7Josep A. Tur8Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands, 07122 Palma de Mallorca, SpainResearch Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands, 07122 Palma de Mallorca, SpainResearch Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands, 07122 Palma de Mallorca, SpainRadiodiagnosis Service, Red Asistencial Juaneda, 07011 Palma de Mallorca, SpainResearch Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands, 07122 Palma de Mallorca, SpainResearch Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands, 07122 Palma de Mallorca, SpainDepartment of Pedagogy and Specific Didactics, University of the Balearic Islands, 07122 Palma de Mallorca, SpainCardiometabolics Precision Nutrition Program, IMDEA Food, CEI UAM-CSIC, 28049 Madrid, SpainResearch Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands, 07122 Palma de Mallorca, SpainBackground: A lifestyle with regular PA (physical activity) and Mediterranean diet has benefits on NAFLD (non-alcoholic fatty liver disease) and MetS (metabolic syndrome). Objectives: To assess the association between physical activity and NAFLD in adults with MetS. Design: Cross-sectional study in 155 participants (40–60 years old) from Balearic Islands and Navarra (Spain) with diagnosis of NAFLD and MetS, and BMI (body mass index) between 27 and 40 Kg/m<sup>2</sup>. Methods: PA level was categorized into two groups according to weekly METs (metabolic equivalents of tasks). PA was assessed using a validated Minnesota questionnaire and accelerometers. MetS parameters were assessed by blood collection analysis and NAFLD by abdominal MRI (magnetic resonance imaging). Results: Participants with high PA showed more energy expenditure and expended more calories than ingested (−143.9 Kcal/day; <i>p</i> < 0.001). PA was a risk factor for AST (aspartate aminotransferase) (adjusted OR: 7.26; 95% CI: 1.79–29.40) and a protective factor for ALT (alanine aminotransferase) (adjusted OR: 0.24; 95% CI: 0.12–0.48), GGT (gamma-glutamyl transferase) (adjusted OR: 0.52; 95% CI: 0.29–0.94) and IFC-NMR (intrahepatic fat content by nuclear magnetic resonance) (adjusted OR: 0.26; 95% CI: 0.12–0.56) when sociodemographic confounders were considered. Conclusions: NAFLD patients with high PA showed more positive relationship on MetS parameters and liver profile (ALT, GGT, IFC-NMR) than subjects with low PA, but not for AST. Difference between calories ingested and expended influenced this relationship.https://www.mdpi.com/2072-6643/14/5/1063physical activityMediterranean dietMediterranean lifestylemetabolic syndromenon-alcoholic fatty liver disease |
| spellingShingle | Catalina M. Mascaró Cristina Bouzas Sofia Montemayor Miguel Casares Cristina Gómez Lucía Ugarriza Pere-Antoni Borràs José Alfredo Martínez Josep A. Tur Association between Physical Activity and Non-Alcoholic Fatty Liver Disease in Adults with Metabolic Syndrome: The FLIPAN Study Nutrients physical activity Mediterranean diet Mediterranean lifestyle metabolic syndrome non-alcoholic fatty liver disease |
| title | Association between Physical Activity and Non-Alcoholic Fatty Liver Disease in Adults with Metabolic Syndrome: The FLIPAN Study |
| title_full | Association between Physical Activity and Non-Alcoholic Fatty Liver Disease in Adults with Metabolic Syndrome: The FLIPAN Study |
| title_fullStr | Association between Physical Activity and Non-Alcoholic Fatty Liver Disease in Adults with Metabolic Syndrome: The FLIPAN Study |
| title_full_unstemmed | Association between Physical Activity and Non-Alcoholic Fatty Liver Disease in Adults with Metabolic Syndrome: The FLIPAN Study |
| title_short | Association between Physical Activity and Non-Alcoholic Fatty Liver Disease in Adults with Metabolic Syndrome: The FLIPAN Study |
| title_sort | association between physical activity and non alcoholic fatty liver disease in adults with metabolic syndrome the flipan study |
| topic | physical activity Mediterranean diet Mediterranean lifestyle metabolic syndrome non-alcoholic fatty liver disease |
| url | https://www.mdpi.com/2072-6643/14/5/1063 |
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