The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome
MI Sierra,1 A Valdés,2 AF Fernández,1 R Torrecillas,2 MF Fraga2 1Cancer Epigenetics Laboratory, Institute of Oncology of Asturias (IUOPA), Hospital Universitario Central de Asturias (HUCA), Universidad de Oviedo, Oviedo, 2Nanomaterials and Nanotechnology Research Center (CINN-...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-11-01
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| Series: | International Journal of Nanomedicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-effect-of-exposure-to-nanoparticles-and-nanomaterials-on-the-mamma-peer-reviewed-article-IJN |
| _version_ | 1818421379742040064 |
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| author | Sierra MI Valdés A Fernández AF Torrecillas R Fraga MF |
| author_facet | Sierra MI Valdés A Fernández AF Torrecillas R Fraga MF |
| author_sort | Sierra MI |
| collection | DOAJ |
| description | MI Sierra,1 A Valdés,2 AF Fernández,1 R Torrecillas,2 MF Fraga2 1Cancer Epigenetics Laboratory, Institute of Oncology of Asturias (IUOPA), Hospital Universitario Central de Asturias (HUCA), Universidad de Oviedo, Oviedo, 2Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Universidad de Oviedo-Principado de Asturias, El Entrego, Spain Abstract: Human exposure to nanomaterials and nanoparticles is increasing rapidly, but their effects on human health are still largely unknown. Epigenetic modifications are attracting ever more interest as possible underlying molecular mechanisms of gene–environment interactions, highlighting them as potential molecular targets following exposure to nanomaterials and nanoparticles. Interestingly, recent research has identified changes in DNA methylation, histone post-translational modifications, and noncoding RNAs in mammalian cells exposed to nanomaterials and nanoparticles. However, the challenge for the future will be to determine the molecular pathways driving these epigenetic alterations, the possible functional consequences, and the potential effects on health. Keywords: noncoding RNAs, ncRNAs, DNA methylation, histone modification, epigenetics |
| first_indexed | 2024-12-14T13:09:26Z |
| format | Article |
| id | doaj.art-61120b2e5d374d92961d2d8ae8c603f3 |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-12-14T13:09:26Z |
| publishDate | 2016-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-61120b2e5d374d92961d2d8ae8c603f32022-12-21T23:00:14ZengDove Medical PressInternational Journal of Nanomedicine1178-20132016-11-01Volume 116297630630228The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenomeSierra MIValdés AFernández AFTorrecillas RFraga MFMI Sierra,1 A Valdés,2 AF Fernández,1 R Torrecillas,2 MF Fraga2 1Cancer Epigenetics Laboratory, Institute of Oncology of Asturias (IUOPA), Hospital Universitario Central de Asturias (HUCA), Universidad de Oviedo, Oviedo, 2Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Universidad de Oviedo-Principado de Asturias, El Entrego, Spain Abstract: Human exposure to nanomaterials and nanoparticles is increasing rapidly, but their effects on human health are still largely unknown. Epigenetic modifications are attracting ever more interest as possible underlying molecular mechanisms of gene–environment interactions, highlighting them as potential molecular targets following exposure to nanomaterials and nanoparticles. Interestingly, recent research has identified changes in DNA methylation, histone post-translational modifications, and noncoding RNAs in mammalian cells exposed to nanomaterials and nanoparticles. However, the challenge for the future will be to determine the molecular pathways driving these epigenetic alterations, the possible functional consequences, and the potential effects on health. Keywords: noncoding RNAs, ncRNAs, DNA methylation, histone modification, epigeneticshttps://www.dovepress.com/the-effect-of-exposure-to-nanoparticles-and-nanomaterials-on-the-mamma-peer-reviewed-article-IJNNanoparticlesnanomaterialsDNA methylationhistone modificationepigenetics |
| spellingShingle | Sierra MI Valdés A Fernández AF Torrecillas R Fraga MF The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome International Journal of Nanomedicine Nanoparticles nanomaterials DNA methylation histone modification epigenetics |
| title | The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome |
| title_full | The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome |
| title_fullStr | The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome |
| title_full_unstemmed | The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome |
| title_short | The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome |
| title_sort | effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome |
| topic | Nanoparticles nanomaterials DNA methylation histone modification epigenetics |
| url | https://www.dovepress.com/the-effect-of-exposure-to-nanoparticles-and-nanomaterials-on-the-mamma-peer-reviewed-article-IJN |
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