Reacción similar a la enfermedad del suero secundaria al uso de cefalotina: reporte de un caso
Serum sickness (SS) and SS-like reactions (SSLR) are indistinguishable clinical entities but with different pathophysiological processes, particularly regarding its impact on the complement system. The VigiAccess™ database contains only 3 potential SS cases out of 2,890 records for cephalothin repor...
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| Format: | Article |
| Language: | English |
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Asociación Colombiana de Infectología
2022-08-01
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| Series: | Infectio |
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| _version_ | 1811258964370784256 |
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| author | Germán Sepúlveda-Barbosa |
| author_facet | Germán Sepúlveda-Barbosa |
| author_sort | Germán Sepúlveda-Barbosa |
| collection | DOAJ |
| description | Serum sickness (SS) and SS-like reactions (SSLR) are indistinguishable clinical entities but with different pathophysiological processes, particularly regarding its impact on the complement system. The VigiAccess™ database contains only 3 potential SS cases out of 2,890 records for cephalothin reported between 1968 and December 2021, but none for SSLR. This commonly used antibiotic was approved in 1974, and its first clinical studies described that all healthy volunteers could produce SSLR depending on the dose and infusion rate. Here we have the case of a young woman, previously healthy, who suffered an ophidian accident receiving both antivenom and cephalothin, in consequence she developed an apparent SS requiring re-hospitalization, because there was no complement activation and consumption, her recovery was complete and uncomplicated, it was defined as a probable SSLR. |
| first_indexed | 2024-04-12T18:23:30Z |
| format | Article |
| id | doaj.art-61122a7aed5044fb8b704c90396bb57b |
| institution | Directory Open Access Journal |
| issn | 0123-9392 |
| language | English |
| last_indexed | 2024-04-12T18:23:30Z |
| publishDate | 2022-08-01 |
| publisher | Asociación Colombiana de Infectología |
| record_format | Article |
| series | Infectio |
| spelling | doaj.art-61122a7aed5044fb8b704c90396bb57b2022-12-22T03:21:21ZengAsociación Colombiana de InfectologíaInfectio0123-93922022-08-01264465467https://doi.org/10.22354/24223794.1099Reacción similar a la enfermedad del suero secundaria al uso de cefalotina: reporte de un casoGermán Sepúlveda-Barbosa01 Laboratorio Integrado de Medicina Especializada (LIME), Facultad de Medicina, IPS Universitaria, Universidad de Antioquia, Medellín, Antioquia, Colombia. 2 Convenio docente-asistencial, Hospital Universitario San Vicente Fundación, Medellín, Antioquia, Colombia Serum sickness (SS) and SS-like reactions (SSLR) are indistinguishable clinical entities but with different pathophysiological processes, particularly regarding its impact on the complement system. The VigiAccess™ database contains only 3 potential SS cases out of 2,890 records for cephalothin reported between 1968 and December 2021, but none for SSLR. This commonly used antibiotic was approved in 1974, and its first clinical studies described that all healthy volunteers could produce SSLR depending on the dose and infusion rate. Here we have the case of a young woman, previously healthy, who suffered an ophidian accident receiving both antivenom and cephalothin, in consequence she developed an apparent SS requiring re-hospitalization, because there was no complement activation and consumption, her recovery was complete and uncomplicated, it was defined as a probable SSLR.serum sicknessdrug-related side effects and adverse reactionscase report |
| spellingShingle | Germán Sepúlveda-Barbosa Reacción similar a la enfermedad del suero secundaria al uso de cefalotina: reporte de un caso Infectio serum sickness drug-related side effects and adverse reactions case report |
| title | Reacción similar a la enfermedad del suero secundaria al uso de cefalotina: reporte de un caso |
| title_full | Reacción similar a la enfermedad del suero secundaria al uso de cefalotina: reporte de un caso |
| title_fullStr | Reacción similar a la enfermedad del suero secundaria al uso de cefalotina: reporte de un caso |
| title_full_unstemmed | Reacción similar a la enfermedad del suero secundaria al uso de cefalotina: reporte de un caso |
| title_short | Reacción similar a la enfermedad del suero secundaria al uso de cefalotina: reporte de un caso |
| title_sort | reaccion similar a la enfermedad del suero secundaria al uso de cefalotina reporte de un caso |
| topic | serum sickness drug-related side effects and adverse reactions case report |
| work_keys_str_mv | AT germansepulvedabarbosa reaccionsimilaralaenfermedaddelsuerosecundariaalusodecefalotinareportedeuncaso |